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Histopathology data for Esco2

Home Genes Esco2 Histopathology

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET M #4 Gall bladder [MA:0000356] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Seminal vesicle [MA:0000410] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Liver [MA:0000358] lipid deposition [MPATH:42] lipid deposition [MPATH:42] 4 4 0 0 steatosis MPATH:622 steatosis MPATH:622 distributed distributed hepatic steatosis hepatic steatosis
HET F #2 Kidney [MA:0000368] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Bone marrow [MA:0000134] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Skeletal muscle [MA:0003148] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Pancreas [MA:0000120] inflammation [MPATH:212] inflammation [MPATH:212] 1 1 0 0 localized localized Focal necrotic pancreatitis Focal necrotic pancreatitis
HET M #3 Lung [MA:0000415] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Skin [MA:0000151] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Esophagus [MA:0000352] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Epididymis [MA:0000397] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Trachea [MA:0000441] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Uterus [MA:0000389] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Testes normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Thyroid normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Urinary bladder [MA:0000380] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Brain [MA:0000168] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3
HET M #4 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Tibia [MA:0001361] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Skeletal muscle [MA:0003148] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Thymus [MA:0000142] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Stomach [MA:0000353] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Eye with optic nerve normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Lung [MA:0000415] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Kidney [MA:0000368] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Trachea [MA:0000441] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Esophagus [MA:0000352] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Femur [MA:0001359] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Adrenal gland [MA:0000116] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Urinary bladder [MA:0000380] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Mammary gland [MA:0000145] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Bone marrow [MA:0000134] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Knee joint [MA:0000471] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Spleen [MA:0000141] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Eye with optic nerve normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Thymus [MA:0000142] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Lung [MA:0000415] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Heart [MA:0000072] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Large intestine [MA:0000333] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Adrenal gland [MA:0000116] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Prostate normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Eye with optic nerve normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Knee joint [MA:0000471] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Thymus [MA:0000142] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Bone marrow [MA:0000134] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Small intestine [MA:0000337] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Small intestine [MA:0000337] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Lymph node [MA:0000139] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Ovary [MA:0000384] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Esophagus [MA:0000352] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Liver [MA:0000358] lipid deposition [MPATH:42] lipid deposition [MPATH:42] 4 4 0 0 steatosis MPATH:622 steatosis MPATH:622 distributed distributed hepatic steatosis hepatic steatosis
HET F #1 Skin [MA:0000151] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Spleen [MA:0000141] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Gall bladder [MA:0000356] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Brain [MA:0000168] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Thyroid normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Tibia [MA:0001361] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Ovary [MA:0000384] hyperplasia [MPATH:134] hyperplasia [MPATH:134] 2 2 0 0 Ovarian stromal hyperplasia Ovarian stromal hyperplasia
HET M #3 Stomach [MA:0000353] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Pancreas [MA:0000120] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Esophagus [MA:0000352] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Lymph node [MA:0000139] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Spleen [MA:0000141] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Femur [MA:0001359] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Brain [MA:0000168] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Gall bladder [MA:0000356] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Stomach [MA:0000353] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Salivary gland [MA:0000346] inflammation [MPATH:212] inflammation [MPATH:212] 1 1 0 0 localized localized Perivascular inflammatory aggregate Perivascular inflammatory aggregate
HET F #2 Knee joint [MA:0000471] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Tibia [MA:0001361] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Seminal vesicle [MA:0000410] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Spinal cord [MA:0000216] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Kidney [MA:0000368] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Lung [MA:0000415] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Pancreas [MA:0000120] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Large intestine [MA:0000333] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Heart [MA:0000072] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Epididymis [MA:0000397] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Testes normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Urinary bladder [MA:0000380] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Trachea [MA:0000441] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Spinal cord [MA:0000216] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Uterus [MA:0000389] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Salivary gland [MA:0000346] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Salivary gland [MA:0000346] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Brain [MA:0000168] developmental dysplasia [MPATH:64] developmental dysplasia [MPATH:64] 1 1 0 0 multi-localised multi-localised Cerebellar granular cell heterotopia Cerebellar granular cell heterotopia
HET F #1 Femur [MA:0001359] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Gall bladder [MA:0000356] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Tibia [MA:0001361] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Eye with optic nerve normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Prostate normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Stomach [MA:0000353] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Knee joint [MA:0000471] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Thymus [MA:0000142] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Liver [MA:0000358] lipid deposition [MPATH:42] lipid deposition [MPATH:42] 4 4 0 0 steatosis MPATH:622 steatosis MPATH:622 distributed distributed hepatic steatosis hepatic steatosis
HET F #2 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Kidney [MA:0000368] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Small intestine [MA:0000337] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Skin [MA:0000151] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Small intestine [MA:0000337] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Large intestine [MA:0000333] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Lymph node [MA:0000139] hyperplasia [MPATH:134] hyperplasia [MPATH:134] 3 3 0 0 distributed distributed Lymphoid hyperplasia with medullary plasmacytosis. Lymphoid hyperplasia with medullary plasmacytosis.
HET M #3 Trachea [MA:0000441] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Heart [MA:0000072] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Adrenal gland [MA:0000116] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Spinal cord [MA:0000216] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Thyroid normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Salivary gland [MA:0000346] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Urinary bladder [MA:0000380] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Femur [MA:0001359] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Mammary gland [MA:0000145] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Bone marrow [MA:0000134] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Liver [MA:0000358] lipid deposition [MPATH:42] lipid deposition [MPATH:42] 4 4 0 0 steatosis MPATH:622 steatosis MPATH:622 distributed distributed hepatic steatosis hepatic steatosis
HET F #1 Spleen [MA:0000141] hyperplasia [MPATH:134] hyperplasia [MPATH:134] 1 1 0 0 extramedullary hemopoiesis MPATH:595 extramedullary hemopoiesis MPATH:595 multifocal to coalescing multifocal to coalescing Mild erythropoiesis Mild erythropoiesis
HET M #3 Skeletal muscle [MA:0003148] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Pancreas [MA:0000120] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Skin [MA:0000151] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #4 Lymph node [MA:0000139] hyperplasia [MPATH:134] hyperplasia [MPATH:134] 3 3 0 0 distributed distributed Lymphoid hyperplasia with medullary plasmacytosis. Lymphoid hyperplasia with medullary plasmacytosis.
HET M #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Spinal cord [MA:0000216] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Adrenal gland [MA:0000116] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Thyroid normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #2 Large intestine [MA:0000333] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Heart [MA:0000072] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] normal [MPATH:458] 0 0 0 0

Associated histopathology images

Esco2
heterozygote
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
MA:0000168 brain
Esco2tm1a(EUCOMM)Wtsi
experimental
Esco2
heterozygote
Esco2tm1a(EUCOMM)Wtsi
experimental
Esco2
heterozygote
Esco2tm1a(EUCOMM)Wtsi
experimental
Esco2
heterozygote
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
Brain MA:0000198
MA:0000168 brain
Esco2tm1a(EUCOMM)Wtsi
experimental

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