Histopathology data for Esco2

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET F #2 Thyroid normal [MPATH:458] 0 0
HET F #2 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET F #2 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET F #3 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET M #1 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #4 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #4 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET F #3 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET F #2 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #1 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #1 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #1 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #1 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #1 Lymph node [MA:0000139] normal [MPATH:458] 0 0
HET F #2 Eye with optic nerve normal [MPATH:458] 0 0
HET F #2 Lung [MA:0000415] normal [MPATH:458] 0 0
HET M #1 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #1 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #3 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #3 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET M #4 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #3 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #3 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #2 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #1 Eye with optic nerve normal [MPATH:458] 0 0
HET M #4 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #3 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET F #2 Ovary [MA:0000384] hyperplasia [MPATH:134] 2 0 Ovarian stromal hyperplasia
HET F #2 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #3 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET M #4 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #4 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #4 Testes normal [MPATH:458] 0 0
HET M #4 Heart [MA:0000072] normal [MPATH:458] 0 0
HET F #2 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #4 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #4 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #1 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #2 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #1
HET M #4 Prostate normal [MPATH:458] 0 0
HET F #3 Skin [MA:0000151] normal [MPATH:458] 0 0
HET M #1 Spleen [MA:0000141] normal [MPATH:458] 0 0
HET M #1 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #4 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #4 Eye with optic nerve normal [MPATH:458] 0 0
HET M #1 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #3 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #3 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET M #1 Testes normal [MPATH:458] 0 0
HET M #1 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #4 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #2 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #2 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #3 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #3 Ovary [MA:0000384] normal [MPATH:458] 0 0
HET F #2 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #3 Femur [MA:0001359] normal [MPATH:458] 0 0
HET M #1 Thyroid normal [MPATH:458] 0 0
HET F #2 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET M #4 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #2 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET M #1 Prostate normal [MPATH:458] 0 0
HET M #4 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #3 Uterus [MA:0000389] normal [MPATH:458] 0 0
HET M #1 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #4 Brain [MA:0000168] normal [MPATH:458] 0 0
HET M #1 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #4 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET F #2 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET F #2 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET M #4 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #3 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #4 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET M #1 Knee joint [MA:0000471] normal [MPATH:458] 0 0
HET M #1 Brain [MA:0000168] developmental dysplasia [MPATH:64] 1 0 multi-localised Cerebellar granular cell heterotopia
HET M #4 Thyroid normal [MPATH:458] 0 0
HET F #3 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #1 Adrenal gland [MA:0000116] normal [MPATH:458] 0 0
HET F #3 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #3 Sternum [MA:0001331] normal [MPATH:458] 0 0
HET F #2 Mammary gland [MA:0000145] normal [MPATH:458] 0 0
HET M #1 Epididymis [MA:0000397] normal [MPATH:458] 0 0
HET M #4 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET M #1 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET F #2 Spleen [MA:0000141] hyperplasia [MPATH:134] 1 0 extramedullary hemopoiesis MPATH:595 multifocal to coalescing Mild erythropoiesis
HET F #3 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0
HET F #3 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET F #3 Lymph node [MA:0000139] hyperplasia [MPATH:134] 3 0 distributed Lymphoid hyperplasia with medullary plasmacytosis.
HET F #3 Thyroid normal [MPATH:458] 0 0
HET F #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET F #2 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #2 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #1 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET M #4 Lymph node [MA:0000139] hyperplasia [MPATH:134] 3 0 distributed Lymphoid hyperplasia with medullary plasmacytosis.
HET F #3 Pancreas [MA:0000120] normal [MPATH:458] 0 0
HET M #1 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #4 Spinal cord [MA:0000216] normal [MPATH:458] 0 0
HET M #1 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET M #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #4 Femur [MA:0001359] normal [MPATH:458] 0 0
HET F #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET M #4 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET F #3 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET M #1 Seminal vesicle [MA:0000410] normal [MPATH:458] 0 0
HET F #3 Eye with optic nerve normal [MPATH:458] 0 0
HET M #4 Skin [MA:0000151] normal [MPATH:458] 0 0
HET F #2 Pancreas [MA:0000120] inflammation [MPATH:212] 1 0 localized Focal necrotic pancreatitis
HET M #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] 0 0
HET F #3 Thymus [MA:0000142] normal [MPATH:458] 0 0
HET F #3 Stomach [MA:0000353] normal [MPATH:458] 0 0
HET M #1 Lung [MA:0000415] normal [MPATH:458] 0 0
HET F #2 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET M #1 Salivary gland [MA:0000346] inflammation [MPATH:212] 1 0 localized Perivascular inflammatory aggregate
HET M #1 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET F #2 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #2 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #1 Liver [MA:0000358] lipid deposition [MPATH:42] 4 0 steatosis MPATH:622 distributed hepatic steatosis
HET M #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] 0 0
HET M #4 Bone marrow [MA:0000134] normal [MPATH:458] 0 0
HET F #3 Small intestine [MA:0000337] normal [MPATH:458] 0 0
HET M #4 Tibia [MA:0001361] normal [MPATH:458] 0 0
HET M #4 Urinary bladder [MA:0000380] normal [MPATH:458] 0 0
HET F #2 Large intestine [MA:0000333] normal [MPATH:458] 0 0
HET F #2 Esophagus [MA:0000352] normal [MPATH:458] 0 0
HET F #2 Kidney [MA:0000368] normal [MPATH:458] 0 0
HET M #4 Gall bladder [MA:0000356] normal [MPATH:458] 0 0
HET F #2 Heart [MA:0000072] normal [MPATH:458] 0 0
HET M #4 Salivary gland [MA:0000346] normal [MPATH:458] 0 0
HET F #3 Trachea [MA:0000441] normal [MPATH:458] 0 0
HET F #3 Brain [MA:0000168] normal [MPATH:458] 0 0
HET F #2 Skeletal muscle [MA:0003148] normal [MPATH:458] 0 0

Associated histopathology images

Esco2
heterozygote
Esco2tm1a(EUCOMM)Wtsi
experimental
Esco2
heterozygote
Brain MA:0000198
MA:0000168 brain
Esco2tm1a(EUCOMM)Wtsi
experimental

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter