**Severity Score:**

- 0 = Normal,
- 1 = Mild (observation barely perceptible and not believed to have clinical significance),
- 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
- 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
- 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

**Significance Score:**

- 0 =
*Not significant*: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate). - 1 =
*Significant*: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.

Zyg | Sex | Mouse | Tissue | MPATH Process Term | Severity Score | Significance Score | MPATH Diagnostic | PATO Descriptor | Free Text | Images |
---|---|---|---|---|---|---|---|---|---|---|

HOM | F | #2 | Tibia [MA:0001361] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Stomach [MA:0000353] | inflammation [MPATH:212] inflammation [MPATH:212] | 2 2 | 0 0 | subacute multi-localised subacute multi-localised | Gastritis, suppurative Gastritis, suppurative | ||

HOM | F | #2 | Spleen [MA:0000141] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Spinal cord [MA:0000216] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Eye with optic nerve | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Small intestine [MA:0000337] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Bone marrow [MA:0000134] | metaplasia [MPATH:160] metaplasia [MPATH:160] | 1 1 | 0 0 | multi-localised multi-localised | lymphoid metaplasia lymphoid metaplasia | ||

HOM | F | #2 | Sternum [MA:0001331] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Thymus [MA:0000142] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Adrenal gland [MA:0000116] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Trigeminal V nerve [MA:0001100] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Knee joint [MA:0000471] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Skeletal muscle [MA:0003148] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Prostate | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Thyroid | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Heart [MA:0000072] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Large intestine [MA:0000333] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Brown adipose tissue [MA:0000057] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Salivary gland [MA:0000346] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Femur [MA:0001359] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Lymph node [MA:0000139] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Skin [MA:0000151] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Liver [MA:0000358] | lipid deposition [MPATH:42] lipid deposition [MPATH:42] | 2 2 | 0 0 | distributed distributed | Hepatic lipidosis Hepatic lipidosis | ||

HOM | M | #3 | Lung [MA:0000415] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Seminal vesicle [MA:0000410] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Testes | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Spinal cord [MA:0000216] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Gall bladder [MA:0000356] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Trachea [MA:0000441] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Lymph node [MA:0000139] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Adrenal gland [MA:0000116] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Brain [MA:0000168] | process of degenerative change [MPATH:14] process of degenerative change [MPATH:14] | 1 1 | 0 0 | hydrocephalus MPATH:639 hydrocephalus MPATH:639 | hydrocephalus, third ventricle hydrocephalus, third ventricle | ||

HOM | F | #2 | Kidney [MA:0000368] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Esophagus [MA:0000352] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Trigeminal V nerve [MA:0001100] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Large intestine [MA:0000333] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Lung [MA:0000415] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Femur [MA:0001359] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Urinary bladder [MA:0000380] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Salivary gland [MA:0000346] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Testes | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Skin [MA:0000151] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Liver [MA:0000358] | lipid deposition [MPATH:42] lipid deposition [MPATH:42] | 2 2 | 0 0 | multi-localised multi-localised | Hepatic lipidosis. Hepatic lipidosis. | ||

HOM | F | #2 | Mammary gland [MA:0000145] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Bone marrow [MA:0000134] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Salivary gland [MA:0000346] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Femur [MA:0001359] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Trachea [MA:0000441] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Thyroid | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Brain [MA:0000168] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Adrenal gland [MA:0000116] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Knee joint [MA:0000471] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Heart [MA:0000072] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Esophagus [MA:0000352] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Spinal cord [MA:0000216] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Seminal vesicle [MA:0000410] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Large intestine [MA:0000333] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Pancreas [MA:0000120] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Kidney [MA:0000368] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Eye with optic nerve | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Epididymis [MA:0000397] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Thymus [MA:0000142] | developmental and structural abnormality [MPATH:55] developmental and structural abnormality [MPATH:55] | 1 1 | 0 0 | localized localized | Focal epithelial inclusion cyst Focal epithelial inclusion cyst | ||

HOM | M | #1 | Small intestine [MA:0000337] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Gall bladder [MA:0000356] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Spleen [MA:0000141] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Skin [MA:0000151] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Skeletal muscle [MA:0003148] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Brown adipose tissue [MA:0000057] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Trigeminal V nerve [MA:0001100] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Lymph node [MA:0000139] | hyperplasia [MPATH:134] hyperplasia [MPATH:134] | 2 2 | 0 0 | distributed subacute distributed subacute | Lymphoid hyperplasia. Lymphoid hyperplasia. | ||

HOM | M | #3 | Stomach [MA:0000353] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Bone marrow [MA:0000134] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Liver [MA:0000358] | lipid deposition [MPATH:42] lipid deposition [MPATH:42] | 2 2 | 0 0 | multi-localised multi-localised | Hepatic lipidosis. Hepatic lipidosis. | ||

HOM | M | #3 | Tibia [MA:0001361] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Spleen [MA:0000141] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Brain [MA:0000168] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Epididymis [MA:0000397] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Thyroid | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Urinary bladder [MA:0000380] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Kidney [MA:0000368] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Pancreas [MA:0000120] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Small intestine [MA:0000337] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Esophagus [MA:0000352] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Sternum [MA:0001331] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Pancreas [MA:0000120] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Eye with optic nerve | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Knee joint [MA:0000471] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Skeletal muscle [MA:0003148] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Thymus [MA:0000142] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Brown adipose tissue [MA:0000057] | inflammation [MPATH:212] inflammation [MPATH:212] | 1 1 | 0 0 | localized localized | Mild lymphocytic steatitis Mild lymphocytic steatitis | ||

HOM | F | #2 | Uterus [MA:0000389] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Gall bladder [MA:0000356] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Heart [MA:0000072] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Sternum [MA:0001331] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Trachea [MA:0000441] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Ovary [MA:0000384] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #3 | Prostate | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Stomach [MA:0000353] | inflammation [MPATH:212] inflammation [MPATH:212] | 1 1 | 0 0 | subacute multi-localised subacute multi-localised | Gastritis, suppurative Gastritis, suppurative | ||

HOM | M | #1 | Tibia [MA:0001361] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | M | #1 | Urinary bladder [MA:0000380] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 | ||||

HOM | F | #2 | Lung [MA:0000415] | normal [MPATH:458] normal [MPATH:458] | 0 0 | 0 0 |