Histopathology data for Ap1s2

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HOM F #3 Tongue [MA:0000347] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Pancreas [MA:0000120] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Uterus [MA:0000389] normal [MPATH:458] 3 1 normal MPATH:458 normal Retinal dysplasia with outer nuclear layer, inner photoreceptor segment and outer photoreceptor segment aplasia
HOM F #4 Mammary gland [MA:0000145] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Lung [MA:0000415] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Small intestine [MA:0000337] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Thyroid normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Small intestine [MA:0000337] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Gall bladder [MA:0000356] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Ear [MA:0000236] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Eye with optic nerve normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Tibia [MA:0001361] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Knee joint [MA:0000471] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Ovary [MA:0000384] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Nasal cavity [MA:0000284] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Thymus [MA:0000142] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Adrenal gland [MA:0000116] developmental and structural abnormality [MPATH:55] developmental dysplasia [MPATH:64] bilateral
HOM F #4 Tooth [MA:0000348] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Liver [MA:0000358] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Tibia [MA:0001361] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Eye with optic nerve normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Sternum [MA:0001331] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Skeletal muscle [MA:0003148] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Tibia [MA:0001361] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Brain [MA:0000168] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Liver [MA:0000358] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Spleen [MA:0000141] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Large intestine [MA:0000333] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Pancreas [MA:0000120] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Skin [MA:0000151] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Bone marrow [MA:0000134] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Urinary bladder [MA:0000380] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Spinal cord [MA:0000216] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Trachea [MA:0000441] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Stomach [MA:0000353] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Liver [MA:0000358] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Nasal cavity [MA:0000284] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Lymph node [MA:0000139] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Bone marrow [MA:0000134] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Salivary gland [MA:0000346] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Stomach [MA:0000353] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Spleen [MA:0000141] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Thyroid normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Gall bladder [MA:0000356] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Femur [MA:0001359] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Skin [MA:0000151] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Epididymis [MA:0000397] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Thymus [MA:0000142] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Bone marrow [MA:0000134] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Esophagus [MA:0000352] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Testes normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Mammary gland [MA:0000145] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Tooth [MA:0000348] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Skeletal muscle [MA:0003148] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Prostate normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Urinary bladder [MA:0000380] normal [MPATH:458] 3 1 normal MPATH:458 normal Retinal dysplasia with outer nuclear layer, inner photoreceptor segment and outer photoreceptor segment aplasia
HEM M #2 Sciatic nerve [MA:0001172] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Salivary gland [MA:0000346] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Bone [MA:0001459] developmental and structural abnormality [MPATH:55] developmental dysplasia [MPATH:64] bilateral
HEM M #1 Pancreas [MA:0000120] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Sciatic nerve [MA:0001172] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Sternum [MA:0001331] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Femur [MA:0001359] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Stomach [MA:0000353] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Brain [MA:0000168] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Lung [MA:0000415] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Ear [MA:0000236] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Tongue [MA:0000347] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Small intestine [MA:0000337] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Spleen [MA:0000141] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Lung [MA:0000415] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Skin [MA:0000151] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Stomach [MA:0000353] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Tooth [MA:0000348] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Lung [MA:0000415] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Tongue [MA:0000347] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Sciatic nerve [MA:0001172] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Brain [MA:0000168] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Brain [MA:0000168] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Skin [MA:0000151] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Large intestine [MA:0000333] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Large intestine [MA:0000333] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Ear [MA:0000236] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Spinal cord [MA:0000216] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Gall bladder [MA:0000356] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Kidney [MA:0000368] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Spleen [MA:0000141] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Large intestine [MA:0000333] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Salivary gland [MA:0000346] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Liver [MA:0000358] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Femur [MA:0001359] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Urinary bladder [MA:0000380] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Tongue [MA:0000347] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Mammary gland [MA:0000145] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Eye with optic nerve normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Heart [MA:0000072] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Heart [MA:0000072] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Ear [MA:0000236] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Uterus [MA:0000389] normal [MPATH:458] 3 1 normal MPATH:458 normal Retinal dysplasia with outer nuclear layer, inner photoreceptor segment and outer photoreceptor segment aplasia
HEM M #1 Kidney [MA:0000368] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Tibia [MA:0001361] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Lymph node [MA:0000139] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Thyroid normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Skeletal muscle [MA:0003148] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Lymph node [MA:0000139] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Heart [MA:0000072] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Esophagus [MA:0000352] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Sciatic nerve [MA:0001172] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Femur [MA:0001359] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Esophagus [MA:0000352] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Testes normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Sternum [MA:0001331] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Lymph node [MA:0000139] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Heart [MA:0000072] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Nasal cavity [MA:0000284] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Trachea [MA:0000441] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Pancreas [MA:0000120] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Trachea [MA:0000441] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Thymus [MA:0000142] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Gall bladder [MA:0000356] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Kidney [MA:0000368] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Knee joint [MA:0000471] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Small intestine [MA:0000337] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Ovary [MA:0000384] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Thyroid normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Salivary gland [MA:0000346] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Eye with optic nerve normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Seminal vesicle [MA:0000410] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Urinary bladder [MA:0000380] normal [MPATH:458] 3 1 normal MPATH:458 normal Retinal dysplasia with outer nuclear layer, inner photoreceptor segment and outer photoreceptor segment aplasia
HEM M #2 Sternum [MA:0001331] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Prostate normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Knee joint [MA:0000471] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Tooth [MA:0000348] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Bone [MA:0001459] normal [MPATH:458] normal MPATH:458 normal
HEM M #1 Bone marrow [MA:0000134] developmental and structural abnormality [MPATH:55] developmental dysplasia [MPATH:64] bilateral
HOM F #3 Spinal cord [MA:0000216] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Epididymis [MA:0000397] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Bone [MA:0001459] developmental and structural abnormality [MPATH:55] developmental dysplasia [MPATH:64] bilateral
HEM M #1 Esophagus [MA:0000352] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Nasal cavity [MA:0000284] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Spinal cord [MA:0000216] normal [MPATH:458] normal MPATH:458 normal
HOM F #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Trachea [MA:0000441] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Knee joint [MA:0000471] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal MPATH:458 normal
HOM F #3 Kidney [MA:0000368] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Mammary gland [MA:0000145] normal [MPATH:458] normal MPATH:458 normal
HEM M #2 Thymus [MA:0000142] normal [MPATH:458] normal MPATH:458 normal

Associated histopathology images

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter