Gene: Acvr1b

Name activin A receptor, type 1B

Synonyms
  • Alk4
  • Acvrlk4
  • ActRIB
  • SKR2
  • ActR-IB

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1338944   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Acvr1b

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Acvr1b data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Acvr1btm1.1(KOMP)Vlcg HET embryonic day 9.5 0.0
abnormal midbrain development Acvr1btm1.1(KOMP)Vlcg HET embryonic day 9.5 0.0
abnormal neural tube closure Acvr1btm1.1(KOMP)Vlcg HET embryonic day 9.5 0.0
embryonic lethality prior to organogenesis Acvr1btm1.1(KOMP)Vlcg HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Acvr1btm1.1(KOMP)Vlcg HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Acvr1btm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
small adrenal glands Acvr1btm1.1(KOMP)Vlcg HET Male postnatal 0.0
small superior vagus ganglion Acvr1btm1.1(KOMP)Vlcg HET Female postnatal 0.0
small testis Acvr1btm1.1(KOMP)Vlcg HET Male postnatal 0.0
increased prepulse inhibition Acvr1btm1.1(KOMP)Vlcg HET Female Male postnatal 8.05E-9
abnormal coat/ hair morphology Acvr1btm1.1(KOMP)Vlcg HET Male postnatal 3.01E-5
abnormal bone structure Acvr1btm1.1(KOMP)Vlcg HET Female Male postnatal 7.02E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Brain 2 No (5/562)
Brainstem 2 No (4/562)
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (19/562) (1/2)
Large intestine 2 No (12/562) (1/2)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393)
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (3/562)
Thymus 2 No
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (1/2)
Uterus 2 No (2/562)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system reproductive system exocrine system
    trunk
    urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    32 Images
  • Eye Morphology: Images Ophthalmoscopy
    8 Images
  • Eye Morphology: Images Slit Lamp
    3 Images
  • Adult LacZ: LacZ Images Section
    4 Images
  • Gross Pathology and Tissue Collection
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Acvr1btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Acvr1btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Acvr1btm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Acvr1btm442836(L1L2_Bact_P)
Vector
Gene