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Histopathology data for Ptpn2

Home Genes Ptpn2 Histopathology

Score Definitions

Severity Score:

  • 0 = Normal,
  • 1 = Mild (observation barely perceptible and not believed to have clinical significance),
  • 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
  • 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
  • 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

  • 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
  • 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.


Zyg Sex Mouse Tissue MPATH Process Term Severity Score Significance Score MPATH Diagnostic PATO Descriptor Free Text Images
HET F #1 Lymph node [MA:0000139] neoplasm [MPATH:218] neoplasm [MPATH:218] Not applicable Not applicable 0 0 lymphoid neoplasms MPATH:513 lymphoid neoplasms MPATH:513 Lymphoma Lymphoma
HET M #3 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Spinal cord [MA:0000216] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Spleen [MA:0000141] hyperplasia [MPATH:134] hyperplasia [MPATH:134] 2 2 0 0 extramedullary hemopoiesis MPATH:595 extramedullary hemopoiesis MPATH:595 multifocal to coalescing multifocal to coalescing mild erythropoiesis mild erythropoiesis
HET F #4 Eye with optic nerve normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Tibia [MA:0001361] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Stomach [MA:0000353] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Pancreas [MA:0000120] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Salivary gland [MA:0000346] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Brown adipose tissue [MA:0000057] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Stomach [MA:0000353] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Thymus [MA:0000142] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Knee joint [MA:0000471] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Lymph node [MA:0000139] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Tibia [MA:0001361] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Femur [MA:0001359] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Femur [MA:0001359] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Spleen [MA:0000141] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Gall bladder [MA:0000356] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Seminal vesicle [MA:0000410] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Salivary gland [MA:0000346] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Brain [MA:0000168] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4
HET F #4 Trachea [MA:0000441] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Kidney [MA:0000368] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Lung [MA:0000415] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Large intestine [MA:0000333] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Brain [MA:0000168] process of degenerative change [MPATH:14] process of degenerative change [MPATH:14] 1 1 0 0 distributed distributed Dilation of the brain ventricles Dilation of the brain ventricles
HET F #4 Uterus [MA:0000389] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Knee joint [MA:0000471] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Epididymis [MA:0000397] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Esophagus [MA:0000352] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Urinary bladder [MA:0000380] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Urinary bladder [MA:0000380] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2
HET M #2 Salivary gland [MA:0000346] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Spinal cord [MA:0000216] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Heart [MA:0000072] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Pancreas [MA:0000120] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Trachea [MA:0000441] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Thymus [MA:0000142] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Kidney [MA:0000368] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Lung [MA:0000415] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Ovary [MA:0000384] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Heart [MA:0000072] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Gall bladder [MA:0000356] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Bone marrow [MA:0000134] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Knee joint [MA:0000471] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Thyroid normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Large intestine [MA:0000333] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Esophagus [MA:0000352] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Small intestine [MA:0000337] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Spleen [MA:0000141] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Prostate normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Bone marrow [MA:0000134] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Thyroid normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Liver [MA:0000358] lipid deposition [MPATH:42] lipid deposition [MPATH:42] 1 1 1 1 multifocal to coalescing multifocal to coalescing Hepatic lipidosis Hepatic lipidosis
HET F #4 Mammary gland [MA:0000145] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Brown adipose tissue [MA:0000057] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Skeletal muscle [MA:0003148] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Eye with optic nerve normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Liver [MA:0000358] lipid deposition [MPATH:42] lipid deposition [MPATH:42] 3 3 0 0 steatosis MPATH:622 steatosis MPATH:622 distributed distributed Hepatic lipidosis Hepatic lipidosis
HET M #2 Spleen [MA:0000141] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Brown adipose tissue [MA:0000057] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Adrenal gland [MA:0000116] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Seminal vesicle [MA:0000410] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Gall bladder [MA:0000356] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Small intestine [MA:0000337] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1
HET F #4 Large intestine [MA:0000333] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Lung [MA:0000415] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Esophagus [MA:0000352] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Skin [MA:0000151] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Skeletal muscle [MA:0003148] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Bone marrow [MA:0000134] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Mammary gland [MA:0000145] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Urinary bladder [MA:0000380] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Epididymis [MA:0000397] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Brain [MA:0000168] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3
HET F #1 Urinary bladder [MA:0000380] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Heart [MA:0000072] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Testes normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Skin [MA:0000151] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Pancreas [MA:0000120] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Sternum [MA:0001331] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Eye with optic nerve normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Spinal cord [MA:0000216] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Thymus [MA:0000142] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Tibia [MA:0001361] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Stomach [MA:0000353] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Tibia [MA:0001361] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Knee joint [MA:0000471] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Kidney [MA:0000368] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Salivary gland [MA:0000346] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Adrenal gland [MA:0000116] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Stomach [MA:0000353] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Femur [MA:0001359] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Femur [MA:0001359] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Trachea [MA:0000441] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Thyroid normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Prostate normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Skin [MA:0000151] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Brain [MA:0000168] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Liver [MA:0000358] lipid deposition [MPATH:42] lipid deposition [MPATH:42] 1 1 1 1 multifocal to coalescing multifocal to coalescing Hepatic lipidosis Hepatic lipidosis
HET M #3 Kidney [MA:0000368] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Small intestine [MA:0000337] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Trachea [MA:0000441] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Thyroid normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Adrenal gland [MA:0000116] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Uterus [MA:0000389] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Skeletal muscle [MA:0003148] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Liver [MA:0000358] lipid deposition [MPATH:42] lipid deposition [MPATH:42] 3 3 0 0 steatosis MPATH:622 steatosis MPATH:622 distributed distributed Hepatic lipidosis Hepatic lipidosis
HET F #4 Esophagus [MA:0000352] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Spinal cord [MA:0000216] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Adrenal gland [MA:0000116] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Brown adipose tissue [MA:0000057] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Large intestine [MA:0000333] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Lymph node [MA:0000139] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Ovary [MA:0000384] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Small intestine [MA:0000337] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Skeletal muscle [MA:0003148] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Skin [MA:0000151] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Lung [MA:0000415] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Eye with optic nerve normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Pancreas [MA:0000120] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Gall bladder [MA:0000356] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Thymus [MA:0000142] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #1 Bone marrow [MA:0000134] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #3 Heart [MA:0000072] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Lymph node [MA:0000139] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET M #2 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal [MPATH:458] 0 0 0 0
HET F #4 Trigeminal V nerve [MA:0001100] normal [MPATH:458] normal [MPATH:458] 0 0 0 0

Associated histopathology images

Ptpn2
heterozygote
Liver MA:0000358
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Liver MA:0000358
MA:0000358 liver
Ptpn2tm1a(EUCOMM)Wtsi
experimental
Ptpn2
heterozygote
Liver MA:0000358
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Liver MA:0000358
Liver MA:0000358
MA:0000358 liver
Ptpn2tm1a(EUCOMM)Wtsi
experimental
Ptpn2
heterozygote
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
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MA:0000358 liver
Ptpn2tm1a(EUCOMM)Wtsi
experimental
Ptpn2
heterozygote
Liver MA:0000358
Liver MA:0000358
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Liver MA:0000358
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Liver MA:0000358
Liver MA:0000358
MA:0000358 liver
Ptpn2tm1a(EUCOMM)Wtsi
experimental
Ptpn2
heterozygote
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
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Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
MA:0000358 liver
Ptpn2tm1a(EUCOMM)Wtsi
experimental
Ptpn2
heterozygote
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
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Liver MA:0000358
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Liver MA:0000358
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Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
MA:0000358 liver
Ptpn2tm1a(EUCOMM)Wtsi
experimental
Ptpn2
heterozygote
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
MA:0000358 liver
Ptpn2tm1a(EUCOMM)Wtsi
experimental
Ptpn2
heterozygote
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
Liver MA:0000358
MA:0000358 liver
Ptpn2tm1a(EUCOMM)Wtsi
experimental

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