Gene: Nr1d1

Order

Name nuclear receptor subfamily 1, group D, member 1

Synonyms
  • REV-ERBalpha
  • A530070C09Rik
  • rev-erbA(alpha)

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:2444210    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Nr1d1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nr1d1 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Eye with optic nerve - process of degenerative change Nr1d1tm1.1(KOMP)Vlcg HOM Female Male postnatal 0.0
Mammary gland - metaplasia Nr1d1tm1.1(KOMP)Vlcg HOM Female postnatal 0.0
abnormal eye morphology Nr1d1tm1(KOMP)Vlcg HOM Female postnatal 0.0
enlarged heart Nr1d1tm1(KOMP)Vlcg HOM Female postnatal 0.0
preweaning lethality, incomplete penetrance Nr1d1tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
short tibia Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 1.24E-12
abnormal eye posterior chamber depth Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 5.22E-9
increased bone mineral content Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 4.01E-8
decreased total body fat amount Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 1.55E-7
abnormal bone structure Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 4.97E-7
thin ventricular wall Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 1.21E-6
decreased total retina thickness Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 5.05E-6
decreased cardiac output Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 9.27E-6
abnormal behavior Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 1.44E-5
decreased vertical activity Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 1.95E-5
abnormal eye anterior chamber depth Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 3.12E-5
decreased circulating alkaline phosphatase level Nr1d1 HET Female postnatal 8.55E-5
hypoactivity Nr1d1tm1(KOMP)Vlcg HOM Female Male postnatal 9.03E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 7 No (2/415) (7/7)
Aorta 7 No (2/7)
Bone 7 No (7/7)
Brain 7 No (7/7)
Brainstem 7 No (7/7)
Brown adipose tissue 7 No (2/7)
Cartilage tissue 7 No (7/7)
Cecum 5 No (12/383) (2/5)
Cerebellum 7 No (7/7)
Cerebral cortex 7 No (7/7)
Esophagus 7 No (7/415) (7/7)
Eye 7 No
Gall bladder 7 No (2/7)
Heart 7 No (7/7)
Hippocampus 7 No (7/7)
Hypothalamus 7 No (7/7)
Kidney 7 No (18/584) (7/7)
Large intestine 7 No (10/584) (2/7)
Liver 7 No (7/7)
Lower urinary tract 7 No (7/7)
Lung 7 No (7/7)
Lymph node 7 No (2/7)
Mammary gland 7 No
Mesenteric lymph node 5 No
Olfactory lobe 7 No (7/7)
Oral epithelium 7 No (2/7)
Ovary 7 No (1/584) (5/7)
Oviduct 7 No (1/7)
Pancreas 7 No (5/584)
Parathyroid gland 7 No
Peripheral nervous system 7 No (2/7)
Peyer's patch 7 No (2/7)
Pituitary gland 7 No (2/7)
Prostate gland 7 No (12/584) (1/7)
Skeletal muscle 7 No (7/7)
Skin 7 No (6/7)
Small intestine 7 No (9/584) (7/7)
Spinal cord 7 No (7/7)
Spleen 7 No (2/584)
Stomach 7 No (12/584) (2/7)
Striatum 7 No (7/7)
Testis 7 No (2/584) (2/7)
Thymus 7 No (2/7)
Thyroid gland 7 No (15/584) (2/7)
Trachea 7 No (7/7)
Trigeminal V nerve 5 No (2/5)
Urinary bladder 5 No
Uterus 7 No (1/7)
Vas deferens 7 No (15/388)
Vascular system 7 No
White adipose tissue 7 No (2/7)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2 (1/47)
Axial skeleton 2 (1/51)
Brain 2 (6/485)
Central nervous system ganglion 2 (1/51)
Cranium 2 (1/46)
Dorsal root ganglion 2 (1/47)
Ear 2 (1/485) (2/2)
Embryo 2 (1/485) (2/2)
Outer ear 2 (1/47)
Eye 2 (1/485) (2/2)
Femur pre-cartilage condensation 2 (1/46)
Foot 2 (1/485)
Forearm 2 (1/282) (2/2)
Forebrain 2 (1/485)
Forelimb 2 (1/485) (2/2)
Fronto-nasal process 2 (1/48)
Gut 2 (1/50)
Hand 2 (1/485)
Head 2 (5/485) (2/2)
Head mesenchyme 2 (1/47)
Heart 2 (1/485) (2/2)
Heart ventricle 2 (1/47) (2/2)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485)
Humerus pre-cartilage condensation 2 (1/46)
Inner ear 2 (1/46) (2/2)
Intestine 2 (1/47)
Liver 2 (1/485)
Lower leg 2 (1/282)
Lung 2 (1/485)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Mesonephros of female 2 (1/46)
Mesonephros of male 2 (1/46)
Metanephros 2 (1/46)
Midbrain 2 (1/485)
Nasal septum 2 (1/47)
Nose 2 (1/51)
Notochord 2 (1/47)
Oral cavity 2 (1/485)
Outflow tract 2 (1/47) (2/2)
Pancreas 2 (1/46)
Pericardium 2 (1/46)
Pharynx 2 (1/46)
Radius-ulna pre-cartilage condensation 2 (1/46) (2/2)
Rib pre-cartilage condensation 2 (1/46)
Skeleton 2 (1/51)
Skin 2 (1/485)
Spinal cord 2 (1/50)
Stomach 2 (1/46)
Tail 2 (1/485) (2/2)
Tail somite 2 (1/485)
Thoracic vertebral cartilage condensation 2 (1/46)
Tongue 2 (1/46)
Trachea 2 (1/50)
Trunk mesenchyme 2 (1/47)
Umbilical artery embryonic part 2 (1/47)
Umbilical vein embryonic part 2 (1/47)
Upper arm 2 (1/282)
Upper leg 2 (1/282)
Urinary system 2 (1/50)
Vibrissa 2 (1/47)


Associated Images

Associated Images
  • Adult LacZ: LacZ Images Wholemount
    35 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Nr1d1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Nr1d1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Nr1d1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Nr1d1tm438023(L1L2_Bact_P)
Vector
Gene
Nr1d1tm438023(L1L2_GT1_LF2A_LacZ_BetactP_neo)
Vector
Gene