Gene: Otub1

Name OTU domain, ubiquitin aldehyde binding 1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2147616   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Otub1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Otub1 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to tooth bud stage Otub1tm1b(EUCOMM)Hmgu HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Otub1tm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
decreased grip strength Otub1tm1b(EUCOMM)Hmgu HET Female Male postnatal 9.38E-8
decreased lean body mass Otub1tm1b(EUCOMM)Hmgu HET Male postnatal 1.01E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562)
Bone 2 No (1/539)
Brain 2 No (5/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562) (2/2)
Esophagus 2 No (2/393)
Eye 2 No (1/562) (2/2)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (19/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No (2/2)
Ovary 2 No (1/562)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (1/2)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (1/2)
Striatum 2 No (4/562) (2/2)
Testis 2 No (3/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562) (2/2)
Uterus 2 No (2/562)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system
    nervous system
    set of connective tissues
    sensory organ
    reproductive system
    exocrine system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 3 (5/439) (3/7)
Ear 3 (3/7)
Embryo 3 (7/7)
Eye 3 (7/7)
Foot 3 (2/7)
Forebrain 3 (5/7)
Forelimb 3 (5/7)
Hand 3 (2/7)
Head 3 (4/439) (6/7)
Heart 3 (3/7)
Hindbrain 3 (5/439) (1/7)
Hindlimb 3 (5/7)
Liver 3 (1/7)
Lung 3 (3/7)
Mandibular process 3 (3/7)
Maxillary process 3 (3/7)
Midbrain 3 (1/7)
Oral cavity 3 (3/7)
1 (11/26) (2/2)
Skin 3 (3/7)
Tail 3 (3/7)
Tail somite 3 (1/7)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • Echo: M-Mode Images
    31 Images
  • X-ray: XRay Images Dorso Ventral
    20 Images
  • X-ray: XRay Images Lateral Orientation
    20 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Embryo LacZ: LacZ images wholemount
    10 Images
  • Adult LacZ: LacZ Images Wholemount
    15 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Otub1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Otub1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Otub1tm83433(L1L2_Bact_P)
Vector
Gene