Gene: Ascc2

Name activating signal cointegrator 1 complex subunit 2

Synonyms
  • 2610034L15Rik
  • ASC1p100
  • 1700011I11Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1922702   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Ascc2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ascc2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Ascc2tm1b(EUCOMM)Wtsi HOM Female embryonic day 9.5 0.0
abnormal forebrain development Ascc2tm1b(EUCOMM)Wtsi HOM Female embryonic day 9.5 0.0
embryonic growth retardation Ascc2tm1b(EUCOMM)Wtsi HOM Female embryonic day 9.5 0.0
embryonic lethality prior to organogenesis Ascc2tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 9.5 0.0
enlarged spleen Ascc2tm1a(EUCOMM)Wtsi HET Female postnatal 0.0
polydactyly Ascc2tm1b(EUCOMM)Wtsi HET Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Ascc2tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Ascc2tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
abnormal retinal inner nuclear layer morphology Ascc2tm1b(EUCOMM)Wtsi HET Female Male postnatal 4.98E-5
improved glucose tolerance Ascc2tm1a(EUCOMM)Wtsi HET Female Male postnatal 7.43E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354) (2/2)
Aorta 2 No (2/530) (2/2)
Bone 2 No (1/515)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/530) (2/2)
Cecum 2 No (1/325)
Cerebellum 2 No (6/530)
Cerebral cortex 2 No (6/530) (2/2)
Esophagus 2 No (1/354) (2/2)
Eye 2 No (1/530)
Gall bladder 2 No
Heart 2 No (4/530) (2/2)
Hippocampus 2 No (7/530) (2/2)
Hypothalamus 2 No (5/529) (2/2)
Kidney 2 No (13/530) (2/2)
Large intestine 2 No (7/530) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/530) (2/2)
Lung 2 No (4/530) (2/2)
Lymph node 2 No (2/530)
Mammary gland 2 No
Olfactory lobe 2 No (3/354) (2/2)
Oral epithelium 2 No (2/2)
Ovary 2 No (1/530) (1/2)
Oviduct 2 No (1/530) (1/2)
Pancreas 2 No (2/530) (2/2)
Parathyroid gland 2 No (2/516) (2/2)
Peripheral nervous system 2 No (4/530) (1/2)
Peyer's patch 2 No (1/354)
Pituitary gland 2 No (2/530) (2/2)
Prostate gland 2 No (3/530)
Skeletal muscle 2 No
Skin 2 No (2/530)
Small intestine 2 No (5/530)
Spinal cord 2 No (5/530) (2/2)
Spleen 2 No (3/530)
Stomach 2 No (5/530) (2/2)
Striatum 2 No (6/530) (2/2)
Testis 2 No (7/530) (1/2)
Thymus 2 No (1/530)
Thyroid gland 2 No (11/530)
Trachea 2 No (5/530) (2/2)
Trigeminal V nerve 2 No (2/2)
Uterus 2 No (1/530) (1/2)
Vas deferens 2 No (1/331) (1/2)
Vascular system 2 No (1/354)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    respiratory system
    digestive system
    cardiovascular system
    nervous system
    set of connective tissues
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2 No Data (2/3)
Axial skeleton 2 No Data (2/3)
Brain 2 (5/413) (2/3)
Central nervous system ganglion 2 No Data (2/3)
Cranium 2 No Data (2/3)
Dorsal root ganglion 2 No Data (2/3)
Ear 2 (2/3)
Embryo 2 (2/3)
Outer ear 2 No Data (2/3)
Eye 2 (2/3)
Femur pre-cartilage condensation 2 No Data (2/3)
Foot 2 (2/3)
Forearm 2 (2/3)
Forebrain 2 (2/3)
Forelimb 2 (2/3)
Fronto-nasal process 2 (2/3)
Gut 2 No Data (2/3)
Hand 2 (2/3)
Head 2 (4/413) (2/3)
Head mesenchyme 2 No Data (2/3)
Heart 2 (2/3)
Heart ventricle 2 No Data (2/3)
Hindbrain 2 (5/413) (2/3)
Hindlimb 2 (2/3)
Humerus pre-cartilage condensation 2 No Data (2/3)
Inner ear 2 No Data (2/3)
Intestine 2 No Data (2/3)
Liver 2 (2/3)
Lower leg 2 (2/3)
Lung 2 (2/3)
Mandibular process 2 (2/3)
Maxillary process 2 (2/3)
Mesonephros of female 2 No Data (2/3)
Mesonephros of male 2 No Data (2/3)
Metanephros 2 No Data (2/3)
Midbrain 2 (2/3)
Nasal septum 2 No Data (2/3)
Nose 2 No Data (2/3)
Notochord 2 No Data (2/3)
Oral cavity 2 (2/3)
Outflow tract 2 No Data (2/3)
Pancreas 2 No Data (2/3)
Pericardium 2 No Data (2/3)
Pharynx 2 No Data (2/3)
Radius-ulna pre-cartilage condensation 2 No Data (2/3)
Rib pre-cartilage condensation 2 No Data (2/3)
Skeleton 2 No Data (2/3)
Skin 2 (2/3)
Spinal cord 2 No Data (2/3)
Stomach 2 No Data (2/3)
Tail 2 (2/3)
Tail somite 2 (2/3)
Thoracic vertebral cartilage condensation 2 No Data (2/3)
Tongue 2 No Data (2/3)
Trachea 2 No Data (2/3)
Trunk mesenchyme 2 No Data (2/3)
Umbilical artery embryonic part 2 No Data (2/3)
Umbilical vein embryonic part 2 No Data (2/3)
Upper arm 2 (2/3)
Upper leg 2 (2/3)
Urinary system 2 No Data (2/3)
Vibrissa 2 No Data (2/3)


Associated Images

Associated Images
  • X-ray: XRay Images Skull Lateral Orientation
    28 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    28 Images
  • Adult LacZ: LacZ Images Wholemount
    15 Images
  • X-ray: XRay Images Forepaw
    28 Images
  • X-ray: XRay Images Dorso Ventral
    28 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • Embryo LacZ: LacZ images wholemount
    6 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Ascc2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ascc2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Ascc2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene