Gene: Adam17

Order

Name a disintegrin and metallopeptidase domain 17

Synonyms
  • CD156b
  • Tace

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1096335    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Adam17

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Adam17 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Adam17tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
increased body weight Adam17tm1a(EUCOMM)Wtsi HET Female Male postnatal 4.09E-9

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (1/2)
Aorta 2 No (1/562)
Blood vessel 2 No (2/2)
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562) (2/2)
Gall bladder 2 No
Heart 2 No (3/562) (1/2)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle tissue 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (1/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system digestive system cardiovascular system nervous system sensory organ reproductive system immune system exocrine system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (10)
  • Adam17tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI

show all 10 images

trunk (6)
  • Adam17tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    stomach, HET, Female, WTSI

show all 6 images

nervous system (3)
  • Adam17tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
cardiovascular system (2)
  • Adam17tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    blood vessel, HET, Female, WTSI
urinary system (2)
  • Adam17tm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
digestive system (1)
  • Adam17tm1a(EUCOMM)Wtsi
    stomach, HET, Female, WTSI
reproductive system (1)
  • Adam17tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
sensory organ (1)
  • Adam17tm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (61)
  • Adam17tm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    head, WT, Male, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    head, HET, Male, WTSI

show all 61 images

Skin Histopathology (3)
  • Adam17tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Adam17tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Adam17tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Adam17tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene