Gene: Cish

Order

Name cytokine inducible SH2-containing protein

Synonyms
  • cytokine-inducible SH2 protein
  • F23
  • Cis
  • CIS1

Status ES CellsMice
tm1a
phenotype data available

Links MGI:103159    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Cish

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Cish data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal behavior Cishtm1a(KOMP)Wtsi HOM Male postnatal 8.46E-6
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Cishtm1a(KOMP)Wtsi HOM Female Male postnatal 7.63E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 0 No (2/2)
Aorta 0 No (1/562)
Blood vessel 0 No (2/2)
Bone 0 No (1/539)
Brain 0 No (6/562) (2/2)
Brainstem 0 No (4/562)
Brown adipose tissue 0 No (2/2)
Cartilage tissue 0 No (1/562) (2/2)
Cerebellum 0 No (4/562)
Cerebral cortex 0 No (5/562)
Eye 0 No (1/562) (2/2)
Gall bladder 0 No (2/2)
Heart 0 No (3/562) (2/2)
Hippocampus 0 No (5/562)
Hypothalamus 0 No (4/562)
Kidney 0 No (20/562) (2/2)
Large intestine 0 No (12/562) (2/2)
Liver 0 No (2/2)
Lower urinary tract 0 No (3/562) (2/2)
Lung 0 No (3/562) (2/2)
Lymph node 0 No (1/562) (2/2)
Mammary gland 0 No (1/2)
Esophagus 0 No (2/2)
Olfactory lobe 0 No
Ovary 0 No (1/562) (1/2)
Oviduct 0 No (2/562) (1/2)
Pancreas 0 No (6/562) (2/2)
Parathyroid gland 0 No (2/540) (2/2)
Peripheral nervous system 0 No (3/562) (2/2)
Peyer's patch 0 No (2/2)
Pituitary gland 0 No (1/562) (2/2)
Prostate gland 0 No (5/562) (1/2)
Skeletal muscle tissue 0 No (2/2)
Skin 0 No (1/562) (2/2)
Small intestine 0 No (11/562) (2/2)
Spinal cord 0 No (3/562) (2/2)
Spleen 0 No (4/562) (2/2)
Stomach 0 No (9/562) (2/2)
Striatum 0 No (4/562)
Testis 0 No (4/562) (1/2)
Thymus 0 No (2/2)
Thyroid gland 0 No (16/562) (2/2)
Trachea 0 No (3/562) (2/2)
Uterus 0 No (2/562) (1/2)
White adipose tissue 0 No (1/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system adipose tissue trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (30)
  • Cishtm1a(KOMP)Wtsi
    brain, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    brain, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    oesophagus, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    gall bladder, liver, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    skeletal muscle tissue, white adipose tissue, HOM, Female, WTSI

show all 30 images

trunk (16)
  • Cishtm1a(KOMP)Wtsi
    oesophagus, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    gall bladder, liver, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    testis, HOM, Male, WTSI
  • Cishtm1a(KOMP)Wtsi
    prostate gland, HOM, Male, WTSI
  • Cishtm1a(KOMP)Wtsi
    heart, HOM, Female, WTSI

show all 16 images

immune system (5)
  • Cishtm1a(KOMP)Wtsi
    thymus, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    spleen, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    lymph node, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    large intestine, peyer's patch, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    inguinal fat pad, mammary gland, lymph node, HOM, Female, WTSI
set of connective tissues (5)
  • Cishtm1a(KOMP)Wtsi
    skeletal muscle tissue, white adipose tissue, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    brown adipose tissue, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    blood vessel, cartilage tissue, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    inguinal fat pad, mammary gland, lymph node, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    inguinal fat pad, HOM, Female, WTSI
adipose tissue (4)
  • Cishtm1a(KOMP)Wtsi
    skeletal muscle tissue, white adipose tissue, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    brown adipose tissue, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    inguinal fat pad, mammary gland, lymph node, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    inguinal fat pad, HOM, Female, WTSI
digestive system (4)
  • Cishtm1a(KOMP)Wtsi
    oesophagus, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    gall bladder, liver, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    large intestine, peyer's patch, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    small intestine, HOM, Female, WTSI
nervous system (4)
  • Cishtm1a(KOMP)Wtsi
    brain, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    brain, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    pituitary gland, peripheral nervous system, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    spinal cord, HOM, Male, WTSI
integumental system (3)
  • Cishtm1a(KOMP)Wtsi
    pinna, skin, HOM, Male, WTSI
  • Cishtm1a(KOMP)Wtsi
    skin, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    inguinal fat pad, mammary gland, lymph node, HOM, Female, WTSI
reproductive system (3)
  • Cishtm1a(KOMP)Wtsi
    testis, HOM, Male, WTSI
  • Cishtm1a(KOMP)Wtsi
    prostate gland, HOM, Male, WTSI
  • Cishtm1a(KOMP)Wtsi
    ovary, oviduct, uterus, HOM, Female, WTSI
cardiovascular system (2)
  • Cishtm1a(KOMP)Wtsi
    heart, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    blood vessel, cartilage tissue, HOM, Female, WTSI
endocrine system (2)
  • Cishtm1a(KOMP)Wtsi
    parathyroid gland, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    adrenal gland, HOM, Female, WTSI
exocrine system (2)
  • Cishtm1a(KOMP)Wtsi
    prostate gland, HOM, Male, WTSI
  • Cishtm1a(KOMP)Wtsi
    inguinal fat pad, mammary gland, lymph node, HOM, Female, WTSI
sensory organ (2)
  • Cishtm1a(KOMP)Wtsi
    pinna, skin, HOM, Male, WTSI
  • Cishtm1a(KOMP)Wtsi
    eye, HOM, Female, WTSI
urinary system (2)
  • Cishtm1a(KOMP)Wtsi
    kidney, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HOM, Female, WTSI
musculoskeletal system (1)
  • Cishtm1a(KOMP)Wtsi
    skeletal muscle tissue, white adipose tissue, HOM, Female, WTSI
respiratory system (1)
  • Cishtm1a(KOMP)Wtsi
    lung, HOM, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (57)
  • Cishtm1a(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    body, HOM, Female, WTSI

show all 57 images

Skin Histopathology (3)
  • Cishtm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Cishtm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
Eye Morphology (1)
  • Cishtm1a(KOMP)Wtsi
    eye, abnormal retinal pigmentation, HOM, Male, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Cishtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Cishtm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene