IMPC Gene variants with decreased alpha-beta T cell number
Total number of significant genotype-phenotype associations: 84
Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
---|---|---|---|---|---|---|---|
Arhgef1 Arhgef1tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Arpc1b Arpc1btm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | CD4+ alpha beta T cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Bach2 Bach2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Brd2 Brd2em1(IMPC)Wtsi |
HET | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Clpp Clpptm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD8+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD8+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased alpha-beta T cell number | Alpha beta T cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Cxcr2 Cxcr2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
D6Wsu163e D6Wsu163etm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | Total CD4+ T cells - % of ab T cells Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Dph6 Dph6tm1a(KOMP)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Dph6 Dph6tm1a(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Resting Treg cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Duoxa2 Duoxa2tm1b(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased KLRG1+ CD8 alpha-beta T cell number | KLRG1+ CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Effector Treg cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | Total CD4+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Total Treg cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Gmds Gmdstm1a(KOMP)Wtsi |
HOM | Early adult | decreased alpha-beta T cell number | Total ab T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Hbs1l Hbs1ltm1a(KOMP)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Il27 Il27tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta memory T cell number | CD4+ CD44+ CD62L- alpha beta effector T cell percentage Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Irf5 Irf5tm1e(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta memory T cell number | CD4+ CD44+ CD62L- alpha beta effector T cell number Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Ncf2 Ncf2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased alpha-beta T cell number | Alpha beta T cell number Whole blood peripheral blood leukocyte immunophenotyping |
WTSI 3i |
0.00 | |
Nrbp1 Nrbp1tm3b(EUCOMM)Wtsi |
HET | Early adult | decreased CD4-positive, alpha-beta T cell number | Total CD4+ T cells - % of ab T cells Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Rwdd1 Rwdd1tm1b(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Sgsm1 Sgsm1tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | Total CD4+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Sik3 Sik3tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | Total CD4+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Sik3 Sik3tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased alpha-beta T cell number | Total ab T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Tmem126a Tmem126atm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | Total CD4+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Tmem126a Tmem126atm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased alpha-beta T cell number | Total ab T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Tmem127 Tmem127tm1(KOMP)Wtsi |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Resting CD8+ T cells - % of CD45+ Mesenteric Lymph Node Immunophenotyping |
WTSI 3i |
0.00 | |
Tmem127 Tmem127tm1(KOMP)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | Total CD4+ T cells - % of ab T cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Traf2 Traf2tm1a(EUCOMM)Wtsi |
HET | Early adult | decreased CD8-positive, alpha-beta T cell number | Total CD8+ T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Traf2 Traf2tm1a(EUCOMM)Wtsi |
HET | Early adult | decreased alpha-beta T cell number | Total ab T cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
Card11 Card11em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Treg cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
5.96×10-39 | |
Psmb11 Psmb11em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
5.75×10-24 | |
Cd38 Cd38em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Treg cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
4.52×10-20 | |
Elk4 Elk4tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | T cell CD4+ percentage FACs Analysis |
HMGU EuroPhenome |
2.71×10-16 | |
Card11 Card11em1(IMPC)Ccpcz |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Naïve CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
4.81×10-11 | |
Elk4 Elk4tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
HMGU EuroPhenome |
6.47×10-10 | |
Usp12 Usp12tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
HMGU EuroPhenome |
1.75×10-09 | |
Nr1d2 Nr1d2tm1Dgen |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
ICS EuroPhenome |
4.92×10-09 | |
Apbb1ip Apbb1ipem1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
1.32×10-08 | |
Acp2 Acp2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
1.26×10-07 | |
Fam234b Fam234btm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
HMGU EuroPhenome |
3.98×10-07 | |
Cpm Cpmem1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
6.21×10-07 | |
Nub1 Nub1tm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8 T cells Immunophenotyping |
CCP-IMG IMPC |
1.08×10-06 | |
Abcg8 Abcg8tm1b(KOMP)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | CD4 T cells Immunophenotyping |
CCP-IMG IMPC |
1.76×10-06 | |
Gper1 Gper1tm1Dgen |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | T cell CD4+ percentage FACs Analysis |
HMGU EuroPhenome |
3.45×10-06 | |
Tmprss6 Tmprss6tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8 T cells Immunophenotyping |
ICS IMPC |
3.88×10-06 | |
Krtap8-1 Krtap8-1em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | CD4 T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
4.52×10-06 | |
Ppp3cb Ppp3cbem1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | CD4 T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
5.59×10-06 | |
Nub1 Nub1tm1b(EUCOMM)Hmgu |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | CD4 T cells Immunophenotyping |
CCP-IMG IMPC |
6.63×10-06 | |
Aldh2 Aldh2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
7.68×10-06 | |
Asb7 Asb7em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
1.04×10-05 | |
Cd38 Cd38em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | CD4 T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
1.16×10-05 | |
Abcg8 Abcg8tm1b(KOMP)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8 T cells Immunophenotyping |
CCP-IMG IMPC |
1.71×10-05 | |
Acp2 Acp2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | T cell CD4+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
1.80×10-05 | |
Bahd1 Bahd1tm2b(KOMP)Wtsi |
HET | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | CD8 CD44+CD62L+ T cells Immunophenotyping |
ICS IMPC |
1.91×10-05 | |
Rnase10 Rnase10tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | T cell CD4+ percentage FACs Analysis |
ICS EuroPhenome |
2.19×10-05 | |
Serf1 Serf1tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
2.30×10-05 | |
Rnase10 Rnase10tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
ICS EuroPhenome |
3.07×10-05 | |
Gpatch4 Gpatch4em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
3.38×10-05 | |
Prss50 Prss50tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
3.89×10-05 | |
Gper1 Gper1tm1Dgen |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
HMGU EuroPhenome |
4.19×10-05 | |
Prpsap2 Prpsap2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
ICS EuroPhenome |
4.23×10-05 | |
Rnf169 Rnf169tm1a(EUCOMM)Hmgu |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | T cell CD8+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
5.08×10-05 | |
Aldh2 Aldh2tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased CD4-positive, alpha-beta T cell number | T cell CD4+ percentage FACs Analysis |
MRC Harwell EuroPhenome |
5.16×10-05 | |
Cd27 Cd27em1(IMPC)Ccpcz |
HOM | Early adult | decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Treg cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
5.68×10-05 | |
Ppp3cb Ppp3cbem1(IMPC)Ccpcz |
HOM | Early adult | decreased CD8-positive, alpha-beta T cell number | CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
6.50×10-05 | |
Klhl6 Klhl6em1(IMPC)Ccpcz |
HOM | Early adult | decreased effector memory CD8-positive, alpha-beta T cell number | Naïve CD8+ T cells - % of live leukocytes (Panel A) Immunophenotyping |
CCP-IMG IMPC |
9.23×10-05 |