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Phenotype: increased circulating unsaturated transferrin level

Definition
increase in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test
Synonyms
increased unsaturated iron binding capacity
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased circulating unsaturated transferrin level

Total number of significant genotype-phenotype associations: 10

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Abcb11
Abcb11tm1b(EUCOMM)Hmgu 		HET Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 1.78×10-11
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 3.45×10-09
Cyp7a1
Cyp7a1tm1b(EUCOMM)Wtsi 		HOM Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 3.90×10-08
Pepd
Pepdtm1b(KOMP)Wtsi 		HOM   Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 1.25×10-06
Mettl23
Mettl23em1(IMPC)Hmgu 		HOM Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 3.76×10-06
Col11a2
Col11a2tm1b(KOMP)Wtsi 		HET Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 1.70×10-05
Plekhf2
Plekhf2em1(IMPC)Wtsi 		HOM   Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 2.42×10-05
Msh5
Msh5tm1b(EUCOMM)Wtsi 		HOM   Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 8.49×10-05
Plekha1
Plekha1tm1b(EUCOMM)Hmgu 		HOM Early adult increased circulating unsaturated transferrin level UIBC (unsaturated iron binding capacity)
Clinical Chemistry		 HMGU
IMPC		 9.44×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Fasted Bleed
Terminal Bleed

 Phenotype associations stats

1.84% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating unsaturated transferrin level (9/488)

0.41% females (2/485) 1.04% males (5/483)



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