Phenotype: increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
Definition a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
Synonyms
- increased suppressor T-lymphocyte number
- increased suppressor T-lymphocyte number
- increased CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number
- increased CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number
- increased suppressor T lymphocyte number
- increased suppressor T cell number
- increased CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number
- increased CD4-positive, CD25-positive, alpha-beta regulatory T-cell number
- increased suppressor T-cell number
- increased CD4-positive, CD25-positive, alpha-beta Treg number
Related
Synonyms
Synonyms
- increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number
- increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number
- increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number
- increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number
Procedure
- Immunophenotyping (IMPC, v1)
- Buffy coat peripheral blood leukocyte immunophenotyping (MGP, v1)
- FACS (ICS, v1)
- Immunophenotyping (ICS, v2)
- Immunophenotyping (TCPLA, v1)
- Immunophenotyping (UCDLA, v1)
- Immunophenotyping (HMGULA, v1)
- Immunophenotyping (RBRCLA, v1)
- Mesenteric Lymph Node Immunophenotyping (MGP, v1)
- Spleen Immunophenotyping (MGP, v1)
- Whole blood peripheral blood leukocyte immunophenotyping (SLM, v1)
- Whole blood peripheral blood leukocyte immunophenotyping (MGP, v1)
MP browserMP:0010168
Phenotype associations stats
2.03% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number (27/1328)
1.38% females (18/1300) 1.23% males (16/1297)
Select a parameter
Gene variants with increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
Total number of significant genotype-phenotype associations: 65
Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Procedure | Parameter | Phenotyping Center | Source | P Value | Data |
---|---|---|---|---|---|---|---|---|
Arhgef1 Arhgef1^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Arpc1b Arpc1b^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Arpc1b Arpc1b^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Effector Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Arpc1b Arpc1b^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Total Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Bach2 Bach2^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | Effector Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Bach2 Bach2^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Cog6 Cog6^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Cog6 Cog6^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Effector Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Cog6 Cog6^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Total Treg cells - % of CD4+ | WTSI | 3i | 0.0 | ||
Cttnbp2 Cttnbp2^{tm1b(KOMP)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Effector Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Dph6 Dph6^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Dph6 Dph6^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Effector Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Dph6 Dph6^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Total Treg cells - % of CD4+ | WTSI | 3i | 0.0 | ||
Duoxa2 Duoxa2^{tm1b(KOMP)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Total Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Etv3 Etv3^{em1(IMPC)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage | WTSI | 3i | 0.0 | ||
Gmds Gmds^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Resting Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Hbs1l Hbs1l^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Effector Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Hbs1l Hbs1l^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Total Treg cells - % of CD4+ | WTSI | 3i | 0.0 | ||
Il27 Il27^{tm1b(EUCOMM)Wtsi} |
HOM | postnatal | increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Pclaf Pclaf^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | Resting Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Pepd Pepd^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Spleen Immunophenotyping | Effector Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Setd5 Setd5^{tm1a(EUCOMM)Wtsi} |
HET | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage | WTSI | 3i | 0.0 | ||
Sik3 Sik3^{tm1a(EUCOMM)Hmgu} |
HOM | postnatal | increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ | WTSI | 3i | 0.0 | ||
Sik3 Sik3^{tm1a(EUCOMM)Hmgu} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Mesenteric Lymph Node Immunophenotyping | Total Treg cells - % of CD4+ | WTSI | 3i | 0.0 | ||
Pex3 Pex3^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage | WTSI | 3i | 2.59E-18 | ||
Dennd1b Dennd1b^{tm1a(EUCOMM)Hmgu} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage | WTSI | 3i | 1.0E-7 | ||
Arhgap30 Arhgap30^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage | WTSI | 3i | 1.2E-6 | ||
Tmem127 Tmem127^{tm1(KOMP)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell number | WTSI | 3i | 1.4E-6 | ||
Acer1 Acer1^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage | WTSI | 3i | 2.0E-6 | ||
Spns2 Spns2^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage | WTSI | 3i | 1.99E-5 | ||
Ndufb8 Ndufb8^{tm1a(EUCOMM)Wtsi} |
HET | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell number | WTSI | 3i | 3.11E-5 | ||
Pepd Pepd^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell number | WTSI | 3i | 3.11E-5 | ||
Tmod1 Tmod1^{tm1a(KOMP)Wtsi} |
HET | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage | WTSI | 3i | 3.46E-5 | ||
Erlin2 Erlin2^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage | WTSI | 3i | 4.18E-5 | ||
Wdr37 Wdr37^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage | WTSI | 3i | 5.28E-5 | ||
Camsap3 Camsap3^{tm1a(EUCOMM)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell number | WTSI | 3i | 6.45E-5 | ||
Cish Cish^{tm1a(KOMP)Wtsi} |
HOM | postnatal | increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number | Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage | WTSI | 3i | 7.63E-5 |