Phenotype: increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

Definition a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release

Synonyms
  • increased suppressor T-lymphocyte number
  • increased suppressor T-lymphocyte number
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte number
  • increased suppressor T lymphocyte number
  • increased suppressor T cell number
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte number
  • increased CD4-positive, CD25-positive, alpha-beta regulatory T-cell number
  • increased suppressor T-cell number
  • increased CD4-positive, CD25-positive, alpha-beta Treg number
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Related
Synonyms
  • increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number
  • increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number

MP browserMP:0010168

Phenotype associations stats

2.03% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number (27/1328)

1.38% females (18/1300) 1.23% males (16/1297)

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Gene variants with increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

Total number of significant genotype-phenotype associations: 65

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ WTSI | 3i 0.0
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ WTSI | 3i 0.0
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Effector Treg cells - % of CD45+ WTSI | 3i 0.0
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Total Treg cells - % of CD45+ WTSI | 3i 0.0
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | Effector Treg cells - % of CD45+ WTSI | 3i 0.0
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ WTSI | 3i 0.0
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ WTSI | 3i 0.0
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Effector Treg cells - % of CD45+ WTSI | 3i 0.0
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Total Treg cells - % of CD4+ WTSI | 3i 0.0
Cttnbp2
Cttnbp2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Effector Treg cells - % of CD45+ WTSI | 3i 0.0
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ WTSI | 3i 0.0
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Effector Treg cells - % of CD45+ WTSI | 3i 0.0
Dph6
Dph6tm1a(KOMP)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Total Treg cells - % of CD4+ WTSI | 3i 0.0
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Total Treg cells - % of CD45+ WTSI | 3i 0.0
Etv3
Etv3em1(IMPC)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage WTSI | 3i 0.0
Gmds
Gmdstm1a(KOMP)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Resting Treg cells - % of CD45+ WTSI | 3i 0.0
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Effector Treg cells - % of CD45+ WTSI | 3i 0.0
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Total Treg cells - % of CD4+ WTSI | 3i 0.0
Il27
Il27tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ WTSI | 3i 0.0
Pclaf
Pclaftm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | Resting Treg cells - % of CD45+ WTSI | 3i 0.0
Pepd
Pepdtm1a(KOMP)Wtsi
HOM Female Male postnatal increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Spleen Immunophenotyping | Effector Treg cells - % of CD45+ WTSI | 3i 0.0
Setd5
Setd5tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage WTSI | 3i 0.0
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | KLRG1+ Treg cells - % of CD45+ WTSI | 3i 0.0
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Mesenteric Lymph Node Immunophenotyping | Total Treg cells - % of CD4+ WTSI | 3i 0.0
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 2.59E-18
Dennd1b
Dennd1btm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage WTSI | 3i 1.0E-7
Arhgap30
Arhgap30tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage WTSI | 3i 1.2E-6
Tmem127
Tmem127tm1(KOMP)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell number WTSI | 3i 1.4E-6
Acer1
Acer1tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage WTSI | 3i 2.0E-6
Spns2
Spns2tm1a(KOMP)Wtsi
HOM Female postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 1.99E-5
Ndufb8
Ndufb8tm1a(EUCOMM)Wtsi
HET Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell number WTSI | 3i 3.11E-5
Pepd
Pepdtm1a(KOMP)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell number WTSI | 3i 3.11E-5
Tmod1
Tmod1tm1a(KOMP)Wtsi
HET Female postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 3.46E-5
Erlin2
Erlin2tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell percentage WTSI | 3i 4.18E-5
Wdr37
Wdr37tm1a(KOMP)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 5.28E-5
Camsap3
Camsap3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Whole blood peripheral blood leukocyte immunophenotyping | CD4+ CD25+ alpha beta regulatory T cell number WTSI | 3i 6.45E-5
Cish
Cishtm1a(KOMP)Wtsi
HOM Female Male postnatal increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Buffy coat peripheral blood leukocyte immunophenotyping | Treg cell CD25+ percentage WTSI | 3i 7.63E-5

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