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Phenotype: increased follicular B cell number

Definition
greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased follicular B cell number

Total number of significant genotype-phenotype associations: 4

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased follicular B cell number Follicular B cells - % of B2 cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased follicular B cell number Follicular B cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Klrb1
Klrb1tm1b(EUCOMM)Wtsi 		HOM Late adult increased follicular B cell number Follicular B Cells
Immunophenotyping		 HMGU
IMPC		 4.70×10-06
Timp2
Timp2em1(IMPC)Hmgu 		HOM Late adult increased follicular B cell number Follicular B Cells
Immunophenotyping		 HMGU
IMPC		 3.56×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping

 Phenotype associations stats

0.82% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased follicular B cell number (4/487)

0.00% females (0/40) 5.13% males (2/39)

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