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Phenotype: decreased CD4-positive, alpha-beta T cell number

Definition
reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
Synonyms
reduced CD4+ T cell number,  decreased CD4-positive T cell number,  decreased CD4+ T cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased CD4-positive, alpha-beta T cell number

Total number of significant genotype-phenotype associations: 28

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM Early adult decreased CD4-positive, alpha-beta T cell number CD4+ alpha beta T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
D6Wsu163e
D6Wsu163etm1b(EUCOMM)Wtsi 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Duoxa2
Duoxa2tm1b(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Resting Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Effector Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Total Treg cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Il27
Il27tm1b(EUCOMM)Wtsi 		HOM Early adult decreased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Irf5
Irf5tm1e(EUCOMM)Wtsi 		HOM Early adult decreased CD4-positive, alpha-beta memory T cell number CD4+ CD44+ CD62L- alpha beta effector T cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Nrbp1
Nrbp1tm3b(EUCOMM)Wtsi 		HET   Early adult decreased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sgsm1
Sgsm1tm1b(EUCOMM)Wtsi 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Tmem126a
Tmem126atm1a(EUCOMM)Wtsi 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number Total CD4+ T cells - % of ab T cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Card11
Card11em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.18×10-36
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.30×10-20
Elk4
Elk4tm1a(EUCOMM)Wtsi 		HOM Early adult decreased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 HMGU
EuroPhenome		 2.71×10-16
Cd27
Cd27em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Treg cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.16×10-07
Abcg8
Abcg8tm1b(KOMP)Wtsi 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number CD4 T cells
Immunophenotyping		 CCP-IMG
IMPC		 1.76×10-06
Krtap8-1
Krtap8-1em1(IMPC)Ccpcz 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number CD4 T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.98×10-06
Gper1
Gper1tm1Dgen 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 HMGU
EuroPhenome		 3.45×10-06
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased CD4-positive, alpha-beta T cell number CD4 T cells
Immunophenotyping		 CCP-IMG
IMPC		 6.63×10-06
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive, alpha-beta T cell number CD4 T cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.45×10-05
Acp2
Acp2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 1.80×10-05
Rnase10
Rnase10tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 ICS
EuroPhenome		 2.19×10-05
Aldh2
Aldh2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased CD4-positive, alpha-beta T cell number T cell CD4+ percentage
FACs Analysis		 MRC Harwell
EuroPhenome		 5.16×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
FACs Analysis
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

2.14% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased CD4-positive, alpha-beta T cell number (22/1028)

1.13% females (6/532) 1.23% males (7/570)

Select a parameter    



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