Phenotype: increased cardiac muscle contractility

Definition greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume

Synonyms
  • increased cardiac muscle contraction
  • increased cardiac muscle contraction
  • increased fractional shortening (FS)
  • increased fractional shortening (FS)
  • increased peak of aortic outflow velocity (PAV)
  • increased velocity of circumferential fiber shortening (Vcfc)
  • increased velocity of circumferential fibre shortening (Vcfc)
  • increased ventricular ejection fraction volume
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Related
Synonyms
increased ventricle muscle contractility

MP browserMP:0005599

Phenotype associations stats

0.83% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac muscle contractility (10/1212)

0.67% females (8/1199) 0.75% males (7/928)

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Gene variants with increased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 15

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM Female postnatal increased cardiac muscle contractility Echo | Ejection Fraction MRC Harwell | IMPC 9.77E-9
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 2.35E-6
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM Male postnatal increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 3.07E-6
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 7.04E-6
Ppp2r2a
Ppp2r2atm1b(KOMP)Wtsi
HET Female postnatal increased cardiac muscle contractility Echo | Fractional Shortening MARC | IMPC 7.65E-6
Ccdc114
Ccdc114tm2b(EUCOMM)Wtsi
HET Male postnatal increased cardiac muscle contractility Echo | Fractional Shortening BCM | IMPC 7.92E-6
Dpp9
Dpp9tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 1.73E-5
Tmem108
Tmem108tm1b(EUCOMM)Wtsi
HOM Female postnatal increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 2.96E-5
Aoc1
Aoc1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 5.94E-5
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET Female Male postnatal increased cardiac muscle contractility Echo | Fractional Shortening HMGU | IMPC 7.32E-5

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