Phenotype: increased cardiac muscle contractility

Definition greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume

Synonyms
  • increased cardiac muscle contraction
  • increased cardiac muscle contraction
  • increased fractional shortening (FS)
  • increased fractional shortening (FS)
  • increased peak of aortic outflow velocity (PAV)
  • increased velocity of circumferential fiber shortening (Vcfc)
  • increased ventricular ejection fraction volume
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Related
Synonyms
  • increased ventricle muscle contractility
  • increased ventricle muscle contractility
  • increased ventricular ejection fraction volume
  • increased ventricular ejection fraction volume

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Phenotype associations stats

0.81% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac muscle contractility (9/1108)

0.73% females (8/1100) 0.60% males (5/833)

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Gene variants with increased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 13

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM Female postnatal increased cardiac muscle contractility Echo | Ejection Fraction MRC Harwell | IMPC 8.35E-9
4933430I17Rik
4933430I17Riktm1b(EUCOMM)Wtsi
HOM Female postnatal increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 1.29E-7
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Female Male postnatal increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 2.1E-6
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM Male postnatal increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 3.07E-6
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET Female Male postnatal increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 7.12E-6
Ppp2r2a
Ppp2r2atm1b(KOMP)Wtsi
HET Female postnatal increased cardiac muscle contractility Echo | Fractional Shortening MARC | IMPC 7.65E-6
Dpp9
Dpp9tm1b(EUCOMM)Hmgu
HET Female Male postnatal increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 1.73E-5
Tmem108
Tmem108tm1b(EUCOMM)Wtsi
HOM Female postnatal increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 3.24E-5
Aoc1
Aoc1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 6.34E-5

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