banner
Genes Phenotypes Help, News, Blog

Phenotype: narrow eye opening

Definition
less than the normal distance from one eyelid to the other without fusion of the eyelid margins
Synonyms
blepharostenosis,  closer roots of eyelids,  narrow palpebral fissure,  blepharophimosis,  small eyelid aperture,  slit eyes,  reduced palpebral fissure size,  closer eyelid folds
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with narrow eye opening

Total number of significant genotype-phenotype associations: 32

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Fgf10
Fgf10tm1b(EUCOMM)Wtsi 		HET Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 1.69×10-23
Barx2
Barx2tm1b(EUCOMM)Hmgu 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 4.76×10-21
Cyb561
Cyb561tm1b(EUCOMM)Wtsi 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 6.49×10-14
Rnf168
Rnf168em1(IMPC)H 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 2.57×10-12
Ctsa
Ctsatm2b(EUCOMM)Hmgu 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 8.09×10-11
Smoc1
Smoc1tm1b(EUCOMM)Wtsi 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 1.10×10-10
Ubac1
Ubac1em1(IMPC)J 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 JAX
IMPC		 1.85×10-09
Spns2
Spns2tm1b(KOMP)Wtsi 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 WTSI
IMPC		 8.60×10-09
Diaph3
Diaph3tm1b(KOMP)Mbp 		HET Late adult narrow eye opening Narrow eye opening
Eye Morphology		 JAX
IMPC		 1.81×10-07
Sirt1
Sirt1tm1b(EUCOMM)Wtsi 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 5.73×10-07
Plekha5
Plekha5em1(IMPC)Tcp 		HOM   Early adult narrow eye opening Narrow eye opening
Eye Morphology		 TCP
IMPC		 7.07×10-07
Kntc1
Kntc1tm1b(EUCOMM)Hmgu 		HOM   Early adult narrow eye opening Narrow eye opening
Eye Morphology		 JAX
IMPC		 1.66×10-06
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 JAX
IMPC		 6.57×10-06
Slc20a2
Slc20a2tm1a(EUCOMM)Wtsi 		HOM   Early adult narrow eye opening Narrow eye opening
Eye Morphology		 WTSI
IMPC		 1.12×10-05
Prepl
Preplem1(IMPC)H 		HOM   Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 1.17×10-05
Pus1
Pus1em1(IMPC)J 		HOM Late adult narrow eye opening Narrow eye opening
Eye Morphology		 JAX
IMPC		 2.42×10-05
Dmac2l
Dmac2ltm1b(EUCOMM)Hmgu 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 2.67×10-05
Spry4
Spry4tm1b(KOMP)Mbp 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 KMPC
IMPC		 3.54×10-05
Mysm1
Mysm1tm1a(KOMP)Wtsi 		HOM Early adult narrow eye opening Eyelid closure
Slit Lamp		 WTSI
EuroPhenome		 4.20×10-05
Txnl1
Txnl1em1(IMPC)Tcp 		HOM   Early adult narrow eye opening Narrow eye opening
Eye Morphology		 TCP
IMPC		 4.67×10-05
Frmd6
Frmd6em1(IMPC)H 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 MRC Harwell
IMPC		 4.89×10-05
Ubl7
Ubl7em1(IMPC)Tcp 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 TCP
IMPC		 5.88×10-05
Cdc45
Cdc45em1(IMPC)Bay 		HET Early adult narrow eye opening Narrow eye opening
Eye Morphology		 BCM
IMPC		 6.23×10-05
Svep1
Svep1tm1b(EUCOMM)Hmgu 		HET Late adult narrow eye opening Narrow eye opening
Eye Morphology		 JAX
IMPC		 6.52×10-05
Zbtb5
Zbtb5tm2b(EUCOMM)Hmgu 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 BCM
IMPC		 6.88×10-05
Dsc2
Dsc2tm1e(KOMP)Wtsi 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 WTSI
IMPC		 7.71×10-05
Thpo
Thpotm1.1(KOMP)Vlcg 		HOM Early adult narrow eye opening Narrow eye opening
Eye Morphology		 UC Davis
IMPC		 8.96×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Eye Morphology
Slit Lamp

 Phenotype associations stats

0.43% of tested genes with null mutations on a B6N genetic background have a phenotype association to narrow eye opening (27/6339)

0.24% females (15/6261) 0.19% males (12/6340)

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter