MP:0004882 (enlarged lung) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: enlarged lung

Definition

increased size of the lung compared to controls

Synonyms

increased lung size

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 12

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Adk Adk^{em1(IMPC)Ccpcz}	HET	Early adult	enlarged lung	Lung Gross Pathology and Tissue Collection	CCP-IMG IMPC	0.00
Cldn18 Cldn18^{tm1.1(KOMP)Vlcg}	HOM	Early adult	enlarged lung	Lung Gross Pathology and Tissue Collection	UC Davis IMPC	0.00
Kcnab3 Kcnab3^{tm1.1(KOMP)Vlcg}	HOM	Early adult	enlarged lung	Lung Gross Pathology and Tissue Collection	UC Davis IMPC	0.00
Lrrc8a Lrrc8a^{tm1.1(KOMP)Vlcg}	HET	Early adult	enlarged lung	Lung Gross Pathology and Tissue Collection	UC Davis IMPC	0.00
Twist2 Twist2^{tm1.1(KOMP)Vlcg}	HET	Early adult	enlarged lung	Lung Gross Pathology and Tissue Collection	UC Davis IMPC	0.00
Vamp4 Vamp4^{em1(IMPC)Ccpcz}	HOM	Early adult	enlarged lung	Lung Gross Pathology and Tissue Collection	CCP-IMG IMPC	0.00
Siglec1 Siglec1^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased lung weight	Left lung weight Organ Weight	UC Davis IMPC	3.97×10^-07
Apbb2 Apbb2^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased lung weight	Left lung weight Organ Weight	UC Davis IMPC	1.71×10^-05
Thbd Thbd^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased lung weight	Right lung weight Organ Weight	UC Davis IMPC	3.98×10^-05
Cldn18 Cldn18^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased lung weight	Left lung weight Organ Weight	UC Davis IMPC	6.34×10^-05
Kcnd1 Kcnd1^{tm1.1(KOMP)Vlcg}	HEM	Early adult	increased lung weight	Left lung weight Organ Weight	UC Davis IMPC	9.89×10^-05

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Procedure
Organ Weight

1.66% of tested genes with null mutations on a B6N genetic background have a phenotype association to enlarged lung (10/602)

14.29% females (3/21) 1.32% males (8/604)

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