Phenotype: abnormal heart left ventricle morphology

Definition any structural anomaly of the left lower chamber of the heart

Synonyms
  • LV abnormality
  • LV abnormality
  • abnormal left ventricle morphology
  • abnormal left ventricle morphology
  • abnormal LV
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Related
Synonyms
  • LV aneurysm
  • LV aneurysm
  • LV to aorta tunnel
  • LV to aorta tunnel
  • LVOTO
  • abnormal LVOT
  • abnormal Sibson vestibule
  • abnormal aortic valve morphology
  • abnormal aortic vestibule morphology
  • abnormal heart left ventricle outflow tract morphology
  • abnormal heart left ventricle weight
  • abnormal left ventricular outflow region morphology
  • abnormal outflow part of left ventricle morphology
  • abnormal outflow tract of left ventricle morphology
  • aortic valvar abnormality
  • aortic valve dysplasia
  • aortic vestibule stenosis
  • aortic-left ventricular tunnel
  • aorto-LV tunnel
  • decreased heart left ventricle weight
  • decreased left ventricle weight
  • heart left ventricle aneurysm
  • heart left ventricle outflow tract obstruction
  • heart left ventricle outflow tract stenosis
  • increased heart left ventricle weight
  • increased left ventricle weight
  • left ventricle to aorta tunnel
  • left ventricular aortic tunnel
  • left ventricular outflow region stenosis
  • outflow part of left ventricle stenosis
  • outflow tract of left ventricle stenosis
  • reduced left ventricle weight
  • subaortic stenosis
  • subvalvar stenosis
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MP browserMP:0003921

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Phenotype associations stats

4.96% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (55/1108)

4.64% females (51/1100) 5.63% males (47/835)

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Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 116

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Wfdc11
Wfdc11em1Marc
HOM Female Male postnatal abnormal heart left ventricle morphology Echo | LVIDd MARC | IMPC 1.19E-29
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HET Female postnatal dilated heart left ventricle Echo | LVIDd MRC Harwell | IMPC 1.67E-23
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM Female postnatal dilated heart left ventricle Echo | LVIDd MRC Harwell | IMPC 1.67E-23
Map3k10
Map3k10tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 1.32E-17
Pcx
Pcxtm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 1.39E-12
Wfdc11
Wfdc11em1Marc
HOM Female Male postnatal increased heart left ventricle size Echo | LVAWd MARC | IMPC 5.19E-12
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 5.88E-12
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 3.23E-9
Fyb
Fybtm1b(EUCOMM)Hmgu
HOM Female postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 1.17E-8
Ints6l
Ints6lem1Marc
HEM Male postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 2.27E-8
Suv39h2
Suv39h2em1Marc
HOM Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.45E-8
Ints6l
Ints6lem1Marc
HEM Male postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 4.08E-8
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM Female postnatal increased heart left ventricle size Echo | LVAWd MRC Harwell | IMPC 4.45E-8
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HET Female postnatal increased heart left ventricle size Echo | LVAWd MRC Harwell | IMPC 4.45E-8
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Female postnatal abnormal heart left ventricle morphology Echo | End-Diastolic Diameter MRC Harwell | IMPC 6.78E-8
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM Female postnatal abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 2.45E-7
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal dilated heart left ventricle Echo | LVIDd BCM | IMPC 2.5E-7
Ints6l
Ints6lem1Marc
HOM Female postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.83E-7
Phf21b
Phf21bem1Marc
HOM Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 4.04E-7
Dnajc17
Dnajc17tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 6.68E-7
Entpd1
Entpd1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 7.2E-7
Cbl
Cbltm1b(EUCOMM)Hmgu
HOM Male postnatal increased heart left ventricle size Echo | LVAWd ICS | IMPC 8.74E-7
Cbl
Cbltm1b(EUCOMM)Hmgu
HET Male postnatal increased heart left ventricle size Echo | LVAWd ICS | IMPC 8.74E-7
Lsm1
Lsm1tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 1.56E-6
Gad2
Gad2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 3.81E-6
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi
HET Female Male postnatal dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 4.19E-6
Abcb11
Abcb11tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 5.71E-6
Abcb11
Abcb11tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 5.71E-6
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM Male postnatal abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 5.75E-6
Ube2z
Ube2zem1Marc
HET Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 6.25E-6
Prmt6
Prmt6em1Marc
HOM Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 6.28E-6
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu
HET Female Male postnatal abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 7.04E-6
Aoc1
Aoc1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 7.34E-6
Btbd9
Btbd9tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 8.81E-6
Vav2
Vav2em1Marc
HOM Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.01E-5
Kdm2b
Kdm2bem1Marc
HET Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.19E-5
Rest
Resttm2b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 1.22E-5
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM Female Male postnatal abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 1.26E-5
Sirt1
Sirt1tm1b(EUCOMM)Wtsi
HOM Female postnatal abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 1.46E-5
Sirt1
Sirt1tm1b(EUCOMM)Wtsi
HET Female postnatal abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 1.46E-5
Aars2
Aars2tm1(KOMP)Wtsi
HET Female postnatal abnormal heart left ventricle morphology Echo | LVIDd MARC | IMPC 1.55E-5
Ccdc83
Ccdc83em1Marc
HOM Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.74E-5
Pard3b
Pard3btm1b(EUCOMM)Wtsi
HOM Male postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.11E-5
Rnf10
Rnf10em2Bay
HOM Female Male postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.31E-5
Cenpe
Cenpetm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 2.57E-5
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi
HOM Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.71E-5
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.71E-5
Gbp2
Gbp2tm1b(KOMP)Wtsi
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 2.82E-5
Rnf144b
Rnf144btm1b(EUCOMM)Hmgu
HOM Female postnatal abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 2.83E-5
Rnf144b
Rnf144btm1b(EUCOMM)Hmgu
HOM Male postnatal dilated heart left ventricle Echo | LVIDs ICS | IMPC 2.83E-5
Siva1
Siva1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 3.1E-5
Ufc1
Ufc1em1Marc
HET Female postnatal abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 3.1E-5
Gsdmd
Gsdmdem1Marc
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 3.36E-5
Esr2
Esr2em1Marc
HOM Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.36E-5
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu
HOM Female postnatal abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 4.06E-5
Itm2c
Itm2ctm1b(EUCOMM)Wtsi
HET Female Male postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 4.32E-5
Itm2c
Itm2ctm1b(EUCOMM)Wtsi
HOM Female Male postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 4.32E-5
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal dilated heart left ventricle Echo | LVIDs HMGU | IMPC 4.7E-5
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM Female Male postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 4.86E-5
Abhd3
Abhd3em1Marc
HOM Female Male postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 5.08E-5
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 5.32E-5
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HET Female Male postnatal dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 5.32E-5
Tead1
Tead1tm1b(KOMP)Wtsi
HET Male postnatal dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 5.94E-5
Tead1
Tead1tm1b(KOMP)Wtsi
HET Female postnatal abnormal heart left ventricle morphology Echo | End-Diastolic Diameter BCM | IMPC 5.94E-5
Hilpda
Hilpdaem1Mhzh
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 6.0E-5
Nfatc3
Nfatc3tm1b(EUCOMM)Hmgu
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 6.46E-5
Trim37
Trim37em1Marc
HOM Female Male postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 6.49E-5
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi
HOM Male postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 7.82E-5
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi
HOM Female postnatal abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 7.82E-5
Ppp2r5e
Ppp2r5eem1Marc
HOM Female Male postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 7.97E-5
Entpd1
Entpd1tm1b(EUCOMM)Wtsi
HET Female Male postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 9.36E-5

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