Phenotype: prolonged PR interval

Definition increase in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex

Synonyms prolonged PR-interval

MP browserMP:0003896

Phenotype associations stats

0.42% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged PR interval (12/2872)

0.35% females (10/2862) 0.35% males (10/2863)



Gene variants with prolonged PR interval

Total number of significant genotype-phenotype associations: 20

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Atrn
Atrntm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 6.16E-8
Pbx3
Pbx3tm1b(EUCOMM)Wtsi
HET Female postnatal prolonged PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 1.23E-6
Grtp1
Grtp1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR TCP | IMPC 7.54E-6
Kbtbd7
Kbtbd7tm1.1(KOMP)Vlcg
HOM Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR JAX | IMPC 7.64E-6
Gabarapl1
Gabarapl1em1(IMPC)J
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR JAX | IMPC 2.27E-5
Nmur1
Nmur1tm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 4.07E-5
Phf19
Phf19tm1.1(KOMP)Vlcg
HOM Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 4.76E-5
Dmp1
Dmp1tm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 7.71E-5
Rgsl1
Rgsl1em1(IMPC)J
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR JAX | IMPC 8.29E-5
Arih2
Arih2tm1.1(KOMP)Vlcg
HET Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 8.52E-5
Wdyhv1
Wdyhv1tm1.1(KOMP)Vlcg
HOM Female postnatal prolonged PR interval Electrocardiogram (ECG) | PR JAX | IMPC 9.45E-5
Klhdc2
Klhdc2tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 9.69E-5

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