Phenotype: prolonged PR interval

Definition increase in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex

Synonyms prolonged PR-interval

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Phenotype associations stats

0.61% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged PR interval (15/2455)

0.53% females (13/2451) 0.49% males (12/2453)



Gene variants with prolonged PR interval

Total number of significant genotype-phenotype associations: 26

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Pde6b
Pde6btm1b(KOMP)Wtsi
HOM Female postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 6.58E-7
Pbx3
Pbx3tm1b(EUCOMM)Wtsi
HET Female postnatal prolonged PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 1.21E-6
Grtp1
Grtp1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR TCP | IMPC 2.04E-6
B2m
B2mtm1b(EUCOMM)Wtsi
HET Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 2.17E-6
Hoxa2
Hoxa2tm1b(EUCOMM)Wtsi
HET Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR HMGU | IMPC 3.35E-6
Dmp1
Dmp1tm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 5.58E-6
Osbpl11
Osbpl11tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR HMGU | IMPC 1.14E-5
Actg1
Actg1tm1.1(KOMP)Vlcg
HET Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 1.42E-5
Ctdspl
Ctdspltm1.1(KOMP)Mbp
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 2.76E-5
Med16
Med16tm1b(KOMP)Wtsi
HET Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 3.51E-5
Fndc9
Fndc9tm1.1(KOMP)Vlcg
HOM Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 5.42E-5
Fndc9
Fndc9tm1.1(KOMP)Vlcg
HET Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 5.42E-5
Arhgap33
Arhgap33tm1b(KOMP)Wtsi
HET Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR BCM | IMPC 5.51E-5
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR JAX | IMPC 7.85E-5
Cacna1f
Cacna1ftm1.1(KOMP)Vlcg
HOM Female postnatal prolonged PR interval Electrocardiogram (ECG) | PR UC Davis | IMPC 9.16E-5
Klhdc2
Klhdc2tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged PR interval Electrocardiogram (ECG) | PR MRC Harwell | IMPC 9.62E-5

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