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Phenotype: decreased circulating alkaline phosphatase level

Definition
reduced concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters
Synonyms
decreased circulating ALP level,  reduced circulating alkaline phosphatase level,  reduced circulating ALP level
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased circulating alkaline phosphatase level

Total number of significant genotype-phenotype associations: 108

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 5.07×10-32
Spred1
Spred1em1(IMPC)Ccpcz 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 CCP-IMG
IMPC		 4.25×10-29
Itch
Itchtm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 1.12×10-28
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 2.79×10-24
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
IMPC		 1.37×10-19
Wbp1l
Wbp1ltm2b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 BCM
IMPC		 1.45×10-17
Clptm1l
Clptm1lem1(IMPC)J 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 JAX
IMPC		 3.47×10-16
Il2ra
Il2ratm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
IMPC		 1.14×10-15
Dbnl
Dbnltm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
IMPC		 3.66×10-12
Cyp19a1
Cyp19a1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 7.42×10-11
Hr
Hrem1(IMPC)H 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 7.61×10-11
Ltn1
Ltn1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 CCP-IMG
IMPC		 9.06×10-11
Xylb
Xylbtm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 2.03×10-10
Vps13b
Vps13bem1(IMPC)Tcp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 3.13×10-10
Grhl3
Grhl3tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 3.28×10-10
Phykpl
Phykpltm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 1.92×10-09
Lbr
Lbrem1(IMPC)Tcp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 2.23×10-09
Rnf10
Rnf10tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 2.66×10-09
Rhbdf2
Rhbdf2Rhbdf2 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 9.42×10-09
4930505A04Rik
4930505A04Riktm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 BCM
IMPC		 2.54×10-08
Txnip
Txniptm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 3.65×10-08
Pkd1
Pkd1tm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 3.92×10-08
Fam210b
Fam210btm1b(KOMP)Mbp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 UC Davis
IMPC		 4.88×10-08
Nrxn1
Nrxn1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 1.07×10-07
Adipor1
Adipor1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
IMPC		 2.06×10-07
Rbfox3
Rbfox3tm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 2.23×10-07
H6pd
H6pdtm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 2.80×10-07
Npr2
Npr2em1(IMPC)H 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 3.74×10-07
Serping1
Serping1em1(IMPC)Mbp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 UC Davis
IMPC		 4.17×10-07
Phf14
Phf14em1(IMPC)Hmgu 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 5.39×10-07
Strap
StrapStrap 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 5.86×10-07
Glrb
Glrbem1(IMPC)Tcp 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 8.76×10-07
Kctd15
Kctd15tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 1.09×10-06
Aldh3a2
Aldh3a2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 1.17×10-06
Scn4a
Scn4atm2b(KOMP)Wtsi 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 1.30×10-06
Nr1d1
Nr1d1Nr1d1 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 1.43×10-06
Csnk1g3
Csnk1g3tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
IMPC		 1.71×10-06
Limd1
Limd1em1(IMPC)H 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 1.83×10-06
Iah1
Iah1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
IMPC		 1.94×10-06
Ubp1
Ubp1tm1b(KOMP)Mbp 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 BCM
IMPC		 2.19×10-06
Kbtbd8
Kbtbd8em1(IMPC)Tcp 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 2.72×10-06
Gzf1
Gzf1em1(IMPC)Tcp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 2.98×10-06
Lrrk1
Lrrk1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 3.44×10-06
Ppp1r17
Ppp1r17em1(IMPC)H 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 3.75×10-06
Teddm1a
Teddm1aem1(IMPC)Tcp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 3.99×10-06
Sst
Ssttm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 RBRC
IMPC		 4.87×10-06
Stat1
Stat1tm2b(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
IMPC		 5.25×10-06
Smad3
Smad3em1(IMPC)H 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 5.92×10-06
Tmem241
Tmem241tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
IMPC		 7.15×10-06
Ing4
Ing4em1(IMPC)Tcp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 7.84×10-06
Ngfr
Ngfrtm1a(EUCOMM)Wtsi 		HET   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 8.04×10-06
Myl2
Myl2tm1b(EUCOMM)Hmgu 		HET   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 8.07×10-06
Mfsd4b4
Mfsd4b4em1(IMPC)J 		HOM Late adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 JAX
IMPC		 8.43×10-06
Blcap
Blcapem1(IMPC)J 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 JAX
IMPC		 8.99×10-06
Cfap36
Cfap36tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
MGP		 1.21×10-05
Zfp558
Zfp558em1(IMPC)Mbp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 UC Davis
IMPC		 1.61×10-05
Prkra
Prkraem1(IMPC)H 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 1.73×10-05
Aldh2
Aldh2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
EuroPhenome		 1.79×10-05
Polr3d
Polr3dem1(IMPC)Tcp 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 1.88×10-05
Rhd
Rhdtm1e(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
EuroPhenome		 2.01×10-05
Selenbp1
Selenbp1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 UC Davis
IMPC		 2.12×10-05
Sbf1
Sbf1em1(IMPC)Mbp 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 UC Davis
IMPC		 2.46×10-05
Card11
Card11em1(IMPC)Ccpcz 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 CCP-IMG
IMPC		 2.56×10-05
Mtmr2
Mtmr2em1(IMPC)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 2.62×10-05
Atp2a2
Atp2a2tm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 2.74×10-05
Cnot4
Cnot4tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
IMPC		 2.89×10-05
Snx8
Snx8tm2a(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
IMPC		 2.94×10-05
Tuft1
Tuft1tm1a(KOMP)Wtsi 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
IMPC		 3.37×10-05
Tfeb
Tfebtm1a(EUCOMM)Wtsi 		HET   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 BCM
IMPC		 3.87×10-05
Rgl3
Rgl3em1(IMPC)H 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 4.20×10-05
Fbrs
Fbrsem1(IMPC)J 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 JAX
IMPC		 4.26×10-05
Lrig3
Lrig3em1(IMPC)Ccpcz 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 CCP-IMG
IMPC		 4.32×10-05
Mtarc2
Mtarc2tm2a(EUCOMM)Hmgu 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 4.34×10-05
Lhx1
Lhx1tm1e(EUCOMM)Wtsi 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
EuroPhenome		 4.59×10-05
Ndufb9
Ndufb9tm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 4.72×10-05
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
IMPC		 5.58×10-05
Prrt2
Prrt2tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 ICS
IMPC		 5.64×10-05
Hectd1
Hectd1tm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MARC
IMPC		 5.75×10-05
Pwwp3a
Pwwp3aem1(IMPC)Tcp 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 5.90×10-05
Klhdc10
Klhdc10em1(IMPC)J 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 JAX
IMPC		 5.95×10-05
Gzf1
Gzf1em1(IMPC)Tcp 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 5.96×10-05
Man2a1
Man2a1em1(IMPC)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 6.12×10-05
Cgref1
Cgref1em1(IMPC)J 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 JAX
IMPC		 6.15×10-05
Tmem116
Tmem116tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 6.79×10-05
Chrna9
Chrna9tm2a(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
EuroPhenome		 6.88×10-05
Fhip1b
Fhip1bem1(IMPC)Tcp 		HOM Late adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 TCP
IMPC		 7.15×10-05
H2-M5
H2-M5tm1(KOMP)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 WTSI
MGP		 7.15×10-05
Tnxb
Tnxbtm1b(EUCOMM)Hmgu 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 7.24×10-05
Tyw1
Tyw1tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 JAX
IMPC		 7.88×10-05
Amelx
Amelxem1(IMPC)Ccpcz 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 CCP-IMG
IMPC		 8.44×10-05
Abca13
Abca13tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 BCM
IMPC		 8.63×10-05
Prkaa2
Prkaa2tm1b(EUCOMM)Hmgu 		HOM   Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 MRC Harwell
IMPC		 8.72×10-05
Cidec
Cidectm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 8.81×10-05
Asphd1
Asphd1em1(IMPC)Ccpcz 		HOM Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 CCP-IMG
IMPC		 9.70×10-05
Psmc2
Psmc2tm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating alkaline phosphatase level Alkaline phosphatase
Clinical Chemistry		 HMGU
IMPC		 9.86×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Terminal Bleed

 Phenotype associations stats

1.28% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating alkaline phosphatase level (93/7280)

0.92% females (67/7250) 0.36% males (26/7211)

Select a parameter    



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