Phenotype: increased heart weight

Definition greater than average weight of the heart compared to controls

Related
Synonyms
  • increased heart left atrium weight
  • increased heart left atrium weight
  • increased heart left ventricle weight
  • increased heart left ventricle weight
  • increased heart right atrium weight
  • increased heart right ventricle weight
  • increased left ventricle weight
  • increased right ventricle weight
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Phenotype associations stats

1.75% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart weight (62/3550)

1.08% females (38/3516) 1.47% males (52/3528)

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Gene variants with increased heart weight

Total number of significant genotype-phenotype associations: 93

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM Female postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 0.0
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.17E-19
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 2.14E-19
Ndufs3
Ndufs3tm1a(EUCOMM)Wtsi
HET Male postnatal increased heart weight Heart Dissection | Heart weight WTSI | MGP 8.31E-13
Gnas
Gnastm1Jop
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.14E-11
Sik1
Sik1tm1.1(KOMP)Vlcg
HOM Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 3.47E-11
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 6.73E-11
Grm6
Grm6tm1b(EUCOMM)Wtsi
HOM Female postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.89E-9
Rab19
Rab19tm1b(EUCOMM)Hmgu
HOM Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 1.21E-8
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Female postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.45E-8
Cidec
Cidectm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 5.1E-8
Dynlrb2
Dynlrb2tm1a(KOMP)Wtsi
HET Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.16E-7
Asns
Asnstm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 1.61E-7
Smurf2
Smurf2tm1b(EUCOMM)Wtsi
HET Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.65E-7
Ash1l
Ash1ltm2b(EUCOMM)Hmgu
HET Male postnatal increased heart weight Heart Weight | Heart weight MARC | IMPC 1.83E-7
Dcp2
Dcp2tm1b(KOMP)Wtsi
HET Female Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 2.37E-7
Spns1
Spns1tm1e(EUCOMM)Wtsi
HET Male postnatal increased heart weight Heart weight/tibia length | Heart weight ICS | MGP 2.92E-7
2810408A11Rik
2810408A11Riktm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 3.77E-7
Lipe
Lipetm1b(KOMP)Wtsi
HOM Female postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 4.02E-7
Dcbld2
Dcbld2tm1a(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 6.14E-7
Gpld1
Gpld1tm1.1(KOMP)Vlcg
HOM Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 7.41E-7
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 9.14E-7
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 9.7E-7
Mtmr12
Mtmr12tm1b(KOMP)Wtsi
HOM Female postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 1.16E-6
Mpdz
Mpdzem1J
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 1.29E-6
Lcn2
Lcn2tm1b(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 1.98E-6
Srcin1
Srcin1tm1.1(KOMP)Vlcg
HET Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 2.59E-6
Srcin1
Srcin1tm1.1(KOMP)Vlcg
HOM Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 2.59E-6
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 2.67E-6
Epb41l5
Epb41l5tm1a(EUCOMM)Hmgu
HET Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 3.14E-6
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Male postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 4.95E-6
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET Male postnatal increased heart weight Heart Weight | Heart weight TCP | IMPC 5.88E-6
Rnf10
Rnf10tm1b(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight TCP | IMPC 5.88E-6
Exd1
Exd1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 5.95E-6
Rimklb
Rimklbtm1.1(KOMP)Vlcg
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 7.28E-6
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Female postnatal increased heart weight Heart Weight | Heart weight TCP | IMPC 7.7E-6
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.1E-6
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 1.09E-5
Stx8
Stx8tm2a(EUCOMM)Wtsi
HOM Female postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.35E-5
Ide
Idetm1a(EUCOMM)Wtsi
HOM Male postnatal increased heart weight Heart Dissection | Heart weight WTSI | MGP 1.79E-5
Lrrc15
Lrrc15tm1b(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 1.8E-5
Pink1
Pink1tm1b(EUCOMM)Wtsi
HOM Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.83E-5
Rcc2
Rcc2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 2.09E-5
Tead1
Tead1tm1b(KOMP)Wtsi
HET Male postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 2.25E-5
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.46E-5
Tmem255b
Tmem255btm1a(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | MGP 2.56E-5
Gsto2
Gsto2tm2a(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 3.01E-5
Fbxo43
Fbxo43em1Marc
HOM Male postnatal increased heart weight Heart Weight | Heart weight MARC | IMPC 3.09E-5
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM Female postnatal increased heart weight Heart weight/tibia length | Heart weight WTSI | EuroPhenome 3.3E-5
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 3.79E-5
Rpa1
Rpa1tm1b(KOMP)Wtsi
HET Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 4.46E-5
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 4.49E-5
Dppa1
Dppa1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 4.6E-5
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.93E-5
Rab36
Rab36tm1b(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.03E-5
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.04E-5
Nos1ap
Nos1aptm1b(KOMP)Wtsi
HOM Male postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 5.13E-5
H2-M5
H2-M5tm1(KOMP)Wtsi
HOM Female Male postnatal increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 5.3E-5
Xylb
Xylbtm1a(EUCOMM)Hmgu
HOM Male postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 6.26E-5
Myo3b
Myo3btm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 6.88E-5
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HOM Female postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 7.11E-5
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HET Female postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 7.11E-5
Nalcn
Nalcnem1Mbp
HET Female Male postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 7.48E-5
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 8.92E-5
Phex
Phexnot yet available
HOM Female postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 9.56E-5

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