MP:0001554 (increased circulating free fatty acids level) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: increased circulating free fatty acids level

Definition

higher than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues

Synonyms

increased UFA level, increased FFA level, increased circulating non-esterified fatty acids level, increased circulating free fatty acid level, increased unesterified fatty acids level

Significant gene associations The way we measure Phenotype stats

of tested genes

significant genes

tested genes

IMPC Gene variants with increased circulating free fatty acids level

Total number of significant genotype-phenotype associations: 43

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Lgals7 Lgals7^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	1.49×10^-09
Col18a1 Col18a1^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	1.58×10^-09
Ccdc18 Ccdc18^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	1.85×10^-09
Ccdc120 Ccdc120^{tm1.1(KOMP)Vlcg}	HEM	Early adult	increased circulating free fatty acids level	Free fatty acids Plasma Chemistry	JAX IMPC	1.08×10^-08
Ap2a2 Ap2a2^{tm1b(EUCOMM)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	1.14×10^-07
Dap Dap^{tm1a(KOMP)Mbp}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	4.17×10^-07
Lonrf3 Lonrf3^{tm1a(KOMP)Wtsi}	HEM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	6.57×10^-07
Ap4e1 Ap4e1^em1(IMPC)J	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	8.11×10^-07
Ift25 Ift25^{tm1a(EUCOMM)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Fasted Clinical Chemistry	WTSI EuroPhenome	9.08×10^-07
Sdha Sdha^{tm2b(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	1.42×10^-06
Tbc1d22a Tbc1d22a^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	1.54×10^-06
Arrb2 Arrb2^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Plasma Chemistry	JAX IMPC	2.22×10^-06
Syce1l Syce1l^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	3.40×10^-06
Zfp637 Zfp637^{em1(IMPC)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	3.56×10^-06
Arhgef4 Arhgef4^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acid Clinical Chemistry	WTSI EuroPhenome	3.94×10^-06
Rc3h2 Rc3h2^{tm1a(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Fasted Clinical Chemistry	HMGU EuroPhenome	5.05×10^-06
Polr2h Polr2h^{tm1.1(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Plasma Chemistry	JAX IMPC	6.63×10^-06
Gm28050 Gm28050^{tm1.1(NCC)WCS}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	7.82×10^-06
Fam110b Fam110b^{tm1e(EUCOMM)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Fasted Clinical Chemistry	HMGU EuroPhenome	7.83×10^-06
Hbs1l Hbs1l^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	1.09×10^-05
Mtrf1l Mtrf1l^{tm1a(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acid Clinical Chemistry	WTSI MGP	1.23×10^-05
Map3k1 Map3k1^{tm1a(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	1.52×10^-05
Car7 Car7^{tm1b(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	2.81×10^-05
Dnajc9 Dnajc9^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	3.32×10^-05
Msx1 Msx1^{tm1b(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	3.77×10^-05
Kcnh3 Kcnh3^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Plasma Chemistry	JAX IMPC	5.06×10^-05
Nfkb1 Nfkb1^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Fasted Clinical Chemistry	WTSI EuroPhenome	5.38×10^-05
Klc2 Klc2^{tm1e(EUCOMM)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	5.91×10^-05
Frrs1 Frrs1^{tm1a(EUCOMM)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	6.07×10^-05
Trmt10a Trmt10a^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acid Clinical Chemistry	WTSI MGP	6.11×10^-05
Tigit Tigit^{tm1.1(IMPC)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	6.58×10^-05
Dhx30 Dhx30^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Plasma Chemistry	JAX IMPC	7.18×10^-05
Ppil3 Ppil3^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	7.38×10^-05
H1f10 H1f10^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	7.63×10^-05
Smyd4 Smyd4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acid Clinical Chemistry	WTSI MGP	7.64×10^-05
Cfh Cfh^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acid Clinical Chemistry	WTSI MGP	7.77×10^-05
Ypel4 Ypel4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	7.86×10^-05
Dctn4 Dctn4^{em1(IMPC)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	WTSI IMPC	8.38×10^-05
Zfp346 Zfp346^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	9.28×10^-05
Itga8 Itga8^{tm1b(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acids Clinical Chemistry	JAX IMPC	9.56×10^-05
Cog2 Cog2^{tm1a(KOMP)Wtsi}	HET	Early adult	increased circulating free fatty acids level	Free fatty acid Clinical Chemistry	WTSI MGP	9.85×10^-05

Download data as: TSV XLS

The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Fasted Clinical Chemistry
Plasma Chemistry
Terminal Bleed

Phenotype associations stats

1.88% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating free fatty acids level (41/2182)

0.69% females (15/2159) 1.01% males (22/2174)

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Phenotype: increased circulating free fatty acids level

IMPC Gene variants with increased circulating free fatty acids level

The way we measure

Phenotype associations stats

The IMPC Newsletter

Access Data Release 20.1 Data