Phenotype: increased circulating free fatty acid level

Definition higher than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues

Synonyms
  • increased UFA level
  • increased UFA level
  • elevated serum free fatty acid levels
  • elevated serum free fatty acid levels
  • increased unesterified fatty acids level
  • increased FFA level
  • increased circulating non-esterified fatty acids level
  • increased NEFA level
  • increased free fatty acids level
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Related
Synonyms
  • Elevated circulating long chain fatty acid concentration
  • Elevated circulating long chain fatty acid concentration
  • Increased circulating myristoleate level
  • Increased circulating myristoleate level
  • Increased circulating octadecanoate level
  • Increased circulating oleate level
  • Increased circulating palmitate level
  • Increased level of myristic acid in serum
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MP browserMP:0001554

Phenotype associations stats

0.83% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased circulating free fatty acid level (18/2175)

0.43% females (9/2091) 0.66% males (14/2106)

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Gene variants with increased circulating free fatty acid level

Total number of significant genotype-phenotype associations: 23

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Lgals7
Lgals7tm1a(EUCOMM)Wtsi
HOM Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 2.4E-9
Rpn2
Rpn2tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | EuroPhenome 1.81E-8
Dap
Daptm1a(KOMP)Mbp
HOM Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 5.35E-8
Syce1l
Syce1ltm1.1(KOMP)Vlcg
HOM Female Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids JAX | IMPC 5.09E-7
Tbc1d22a
Tbc1d22atm1b(KOMP)Wtsi
HOM Female postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.51E-6
Trmt10a
Trmt10atm1a(EUCOMM)Wtsi
HOM Female Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | EuroPhenome 2.47E-6
Lonrf3
Lonrf3tm1a(KOMP)Wtsi
HEM Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 3.76E-6
Coq4
Coq4tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 7.36E-6
Sar1b
Sar1btm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | MGP 7.89E-6
Ppil3
Ppil3tm1b(EUCOMM)Wtsi
HOM Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.28E-5
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Female postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | EuroPhenome 1.32E-5
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids WTSI | IMPC 1.6E-5
Dnajc9
Dnajc9tm1.1(KOMP)Vlcg
HET Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acids JAX | IMPC 2.49E-5
Apoe
Apoetm1Unc
HOM Female Male postnatal increased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids WTSI | EuroPhenome 3.34E-5
Hspb11
Hspb11tm1a(EUCOMM)Wtsi
HET Female postnatal increased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids WTSI | EuroPhenome 3.54E-5
Polr2h
Polr2htm1.1(KOMP)Wtsi
HET Female Male postnatal increased circulating free fatty acid level Plasma Chemistry | Free fatty acids JAX | IMPC 4.69E-5
Nfkb1
Nfkb1tm1a(KOMP)Wtsi
HOM Female Male postnatal increased circulating free fatty acid level Fasted Clinical Chemistry | Free fatty acids WTSI | EuroPhenome 5.03E-5
Ptpn2
Ptpn2tm1a(EUCOMM)Wtsi
HET Male postnatal increased circulating free fatty acid level Clinical Chemistry | Free fatty acid WTSI | EuroPhenome 8.04E-5

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