Phenotype: abnormal liver morphology

Definition any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage

Synonyms
  • liver dysplasia
  • liver dysplasia
  • abnormal hepatic morphology
  • abnormal hepatic morphology
  • abnormal liver
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Related
Synonyms
  • increased liver glycogen level
  • increased liver glycogen level
  • Congenital hepatic fibrosis
  • Congenital hepatic fibrosis
  • Fluctuating hepatomegaly
  • liver abscess
  • Macrovesicular hepatic steatosis
  • Macrovesicular hepatic steatosis
  • liver degeneration
  • increased hepatocyte proliferation
  • abnormal Kupffer cell morphology
  • Periportal fibrosis
  • Microvesicular hepatic steatosis
  • hepatic necrosis
  • abnormal liver regeneration
  • Hepatosplenomegaly
  • liver hemorrhage
  • Hepatic arteriovenous malformation
  • decreased liver glycogen level
  • liver cysts
  • Hepatic cysts
  • Degenerative liver disease
  • Hepatocellular necrosis
  • decreased liver free fatty acids level
  • Fluctuating hepatomegaly
  • increased liver cholesterol level
  • Mixed cirrhosis
  • multifocal hepatic necrosis
  • hepatic arteriovenous malformation
  • delayed hepatic development
  • liver hyperplasia
  • abnormal liver glycogen level
  • Diffuse hepatic steatosis
  • enlarged liver
  • abnormal portal lobule morphology
  • abnormal liver iron level
  • increased liver copper level
  • Hepatic periportal necrosis
  • Acute hepatic steatosis
  • Intrahepatic biliary atresia
  • Congenital hepatic fibrosis
  • abnormal liver parenchyma morphology
  • focal hepatic necrosis
  • abnormal biliary ductule morphology
  • liver hyperplasia
  • increased liver iron level
  • decreased susceptibility to hepatic steatosis
  • abnormal liver weight
  • hepatic peliosis
  • abnormal liver triglyceride level
  • multifocal hepatic necrosis
  • Abnormal liver parenchyma morphology
  • abnormal liver sinusoid morphology
  • Diffuse hepatic steatosis
  • decreased hepatocyte proliferation
  • Periportal fibrosis
  • increased liver regeneration
  • decreased liver iron level
  • absent liver
  • Elevated hepatic iron concentration
  • decreased liver regeneration
  • Copper accumulation in liver
  • liver hypoplasia
  • Acute hepatic steatosis
  • Microvesicular hepatic steatosis
  • abnormal liver zinc level
  • abnormal liver cholesterol level
  • Hepatic fibrosis
  • Hepatic bridging fibrosis
  • Increased hepatic glycogen content
  • decreased liver weight
  • abnormal interlobular bile duct morphology
  • herniated liver
  • increased liver triglyceride level
  • abnormal liver vasculature morphology
  • Hepatic necrosis
  • abnormal intrahepatic bile duct morphology
  • Micronodular cirrhosis
  • diffuse hepatic necrosis
  • abnormal intralobular bile duct morphology
  • abnormal liver copper level
  • pale liver
  • increased liver weight
  • Macronodular cirrhosis
  • increased liver iron level
  • abnormal hepatic cord morphology
  • abnormal liver development
  • Micronodular cirrhosis
  • abnormal liver lobule morphology
  • Hepatic steatosis
  • Liver abscess
  • increased liver weight
  • decreased liver iron level
  • Macronodular cirrhosis
  • Mixed cirrhosis
  • decreased liver triglyceride level
  • liver fibrosis
  • Hepatocellular necrosis
  • decreased liver copper level
  • Hepatomegaly
  • decreased liver cholesterol level
  • increased liver free fatty acids level
  • Hepatic periportal necrosis
  • Elevated hepatic iron concentration
  • Hepatic bridging fibrosis
  • enlarged liver sinusoidal spaces
  • liver vascular congestion
  • Hepatic calcification
  • Abnormal hepatic iron concentration
  • Abnormal liver lobulation
  • abnormal liver bud morphology
  • Intrahepatic bile duct cysts
  • symmetric hepatic veins
  • hepatic steatosis
  • increased liver weight
  • Hepatosplenomegaly
  • focal hepatic necrosis
  • decreased liver weight
  • abnormal hepatic vein morphology
  • abnormal hepatic vein connection
  • diffuse hepatic necrosis
  • liver cirrhosis
  • small liver
  • Cirrhosis
  • abnormal liver size
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MP browserMP:0000598

Phenotype associations stats

1.36% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal liver morphology (35/2576)

0.67% females (17/2555) 1.02% males (26/2546)

Gene variants with abnormal liver morphology

Total number of significant genotype-phenotype associations: 47

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Adnp2
Adnp2em3(IMPC)Tcp
HOM Female postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver TCP | IMPC 0.0
Aif1l
Aif1ltm1b(EUCOMM)Wtsi
HOM Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver BCM | IMPC 0.0
Akap10
Akap10tm1.1(KOMP)Vlcg
HET Male embryonic day 12.5 abnormal liver size Gross Morphology Embryo E12.5 | Liver Size TCP | IMPC 0.0
Bcl2l12
Bcl2l12tm1.1(KOMP)Vlcg
HOM Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Bloc1s2
Bloc1s2tm1.1(KOMP)Mbp
HOM Male embryonic day 12.5 pale liver Gross Morphology Embryo E12.5 | Pale Liver JAX | IMPC 0.0
Cacna1i
Cacna1itm1b(KOMP)Wtsi
HOM Female postnatal small liver Gross Pathology and Tissue Collection | Liver BCM | IMPC 0.0
Ccdc124
Ccdc124tm1b(KOMP)Wtsi
HOM Female Male postnatal small liver Gross Pathology and Tissue Collection | Liver MARC | IMPC 0.0
Cox5b
Cox5btm2b(EUCOMM)Hmgu
HOM Male embryonic day 12.5 abnormal liver size Gross Morphology Embryo E12.5 | Liver Size BCM | IMPC 0.0
Cox5b
Cox5btm2b(EUCOMM)Hmgu
HOM Male embryonic day 12.5 pale liver Gross Morphology Embryo E12.5 | Pale Liver BCM | IMPC 0.0
Cpe
Cpetm1b(EUCOMM)Hmgu
HOM Female Male postnatal enlarged liver Gross Pathology and Tissue Collection | Liver HMGU | IMPC 0.0
Dagla
Daglatm1a(EUCOMM)Wtsi
HOM Male postnatal small liver Gross Pathology and Tissue Collection | Liver MARC | IMPC 0.0
Emb
Embtm1b(KOMP)Wtsi
HET Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Fbxo38
Fbxo38em2(IMPC)Marc
HOM Female postnatal small liver Gross Pathology and Tissue Collection | Liver MARC | IMPC 0.0
Fstl3
Fstl3tm1.1(KOMP)Vlcg
HOM Female postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Gjb4
Gjb4tm1.1(KOMP)Vlcg
HOM Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Gprc5b
Gprc5btm1b(EUCOMM)Wtsi
HOM Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Gps1
Gps1tm1b(KOMP)Wtsi
HET Female Male embryonic day 12.5 abnormal liver size Gross Morphology Embryo E12.5 | Liver Size TCP | IMPC 0.0
Hddc3
Hddc3tm1.1(KOMP)Vlcg
HOM Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Hectd3
Hectd3tm1(NCOM)Cmhd
HOM Female Male postnatal small liver Gross Pathology and Tissue Collection | Liver MARC | IMPC 0.0
Kdm1a
Kdm1atm1(NCOM)Mfgc
HET Female postnatal small liver Gross Pathology and Tissue Collection | Liver MARC | IMPC 0.0
Lhcgr
Lhcgrtm1(KOMP)Vlcg
HOM Male postnatal small liver Gross Pathology and Tissue Collection | Liver MARC | IMPC 0.0
Med16
Med16tm1b(KOMP)Wtsi
HOM Male embryonic day 12.5 pale liver Gross Morphology Embryo E12.5 | Pale Liver TCP | IMPC 0.0
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi
HOM Female Male embryonic day 12.5 pale liver Gross Morphology Embryo E12.5 | Pale Liver BCM | IMPC 0.0
Myo18a
Myo18atm1b(KOMP)Wtsi
HOM Female Male embryonic day 10.5 pale liver Gross Morphology Embryo E12.5 | Pale Liver TCP | IMPC 0.0
Pstpip2
Pstpip2em1(IMPC)Tcp
HOM Female postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver TCP | IMPC 0.0
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi
HOM Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver HMGU | IMPC 0.0
Sec24d
Sec24dem1(IMPC)Rbrc
HET Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver RBRC | IMPC 0.0
St14
St14tm1.1(KOMP)Vlcg
HOM Female Male embryonic day 12.5 abnormal liver size Gross Morphology Embryo E12.5 | Liver Size TCP | IMPC 0.0
St14
St14tm1.1(KOMP)Vlcg
HOM Female Male embryonic day 12.5 pale liver Gross Morphology Embryo E12.5 | Pale Liver TCP | IMPC 0.0
Sufu
Sufutm1b(KOMP)Wtsi
HOM Male embryonic day 12.5 abnormal liver size Gross Morphology Embryo E12.5 | Liver Size TCP | IMPC 0.0
Sufu
Sufutm1b(KOMP)Wtsi
HOM Male embryonic day 12.5 pale liver Gross Morphology Embryo E12.5 | Pale Liver TCP | IMPC 0.0
Supt4a
Supt4atm1b(EUCOMM)Hmgu
HET Female embryonic day 12.5 pale liver Gross Morphology Embryo E12.5 | Pale Liver TCP | IMPC 0.0
Thbs1
Thbs1tm1.1(KOMP)Vlcg
HOM Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Trmt1
Trmt1tm1b(EUCOMM)Hmgu
HET Female postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver ICS | IMPC 0.0
Ube2g1
Ube2g1tm1b(EUCOMM)Hmgu
HOM Male postnatal small liver Gross Pathology and Tissue Collection | Liver RBRC | IMPC 0.0
Ubr2
Ubr2tm1e.1(KOMP)Mbp
HET Female postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Unc119
Unc119tm1.1(KOMP)Vlcg
HOM Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0
Zc3hav1l
Zc3hav1ltm1b(EUCOMM)Wtsi
HOM Female Male postnatal abnormal liver morphology Gross Pathology and Tissue Collection | Liver UC Davis | IMPC 0.0

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