Eye Morphology: Images Ophthalmoscopy

WT Images

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: LEFT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia ; LEFT EYE: A little bit of Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate dysplasia

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia; LEFT EYE: Slight opacity on lens, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Moderate Rd8/dysplasia

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: R eye severe rd8. L eye some rd8 and slight opacity.; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

57 weeks old

Ophthalmoscope Observation: RIGHT EYE: Severe Rd8; LEFT EYE: Slight lens opacity, difficulty focusing, some Rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe Rd8

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8, slight opacity on lens

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens; LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: LEFT EYE: Some rd8, slight opacity on lens,
Ophthalmoscope Observation: RIGHT EYE: Slight opacity on lens

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity, some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

58 weeks old

Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; LEFT EYE:,
Ophthalmoscope Observation: Both eyes Slight opacity on lens, hard to focus; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: Both eyes some rd8,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE:

58 weeks old

Ophthalmoscope Observation: RIGHT EYE: Some rd8; LEFT EYE: Some rd8,
Ophthalmoscope Observation: LEFT EYE: Some rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8

Mutant Images

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes ; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; LEFT EYE: Some hemorrhaging,
Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8.,
Ophthalmoscope Observation: Both eyes severe rd8.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; LEFT EYE: Some hemorrhaging,
Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Hard to focus; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; LEFT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes.,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; LEFT EYE:,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes ; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity; LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8.,
Ophthalmoscope Observation: Both eyes severe rd8.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; LEFT EYE: Slight opacity,
Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; LEFT EYE: Some hemorrhaging,
Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Hard to focus; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity; LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Hard to focus; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes.,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; LEFT EYE:,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes.,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; LEFT EYE:,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; LEFT EYE: Some hemorrhaging,
Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; LEFT EYE: Slight opacity,
Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; LEFT EYE: Slight opacity,
Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Hard to focus; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity; LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; LEFT EYE: Some hemorrhaging,
Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes.,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; LEFT EYE:,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: Both eyes some opacity (difficult to image and focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes ; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8.,
Ophthalmoscope Observation: Both eyes severe rd8.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Both eyes severe rd8 and some opacity (difficult to focus).; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8.,
Ophthalmoscope Observation: Both eyes severe rd8.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8,
Ophthalmoscope Observation: Both eyes moderate rd8; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Hard to focus; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity; LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity; LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes ; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes ; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes.,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; LEFT EYE:,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; LEFT EYE: Slight opacity,
Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity; LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: LEFT EYE: Some rd8 and lens opacity (hard to focus),
Ophthalmoscope Observation: RIGHT EYE: Moderate rd8, slight lens opacity

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8.,
Ophthalmoscope Observation: Both eyes severe rd8.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8.; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes ; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8 and some dysplasia; slight opacity.; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present; LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: LEFT EYE: Moderate rd8,
Ophthalmoscope Observation: RIGHT EYE: Some rd8 and hyloid present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus; RIGHT EYE: Some rd8,
Ophthalmoscope Observation: Hard to focus; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; LEFT EYE: Some hemorrhaging,
Ophthalmoscope Observation: Some rd8 in both eyes. Rapid breathing, difficult to image.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; RIGHT EYE: Some dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity (difficult to focus) in both eyes; LEFT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; LEFT EYE: Slight opacity,
Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and dysplasia and some opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; LEFT EYE: Slight opacity,
Ophthalmoscope Observation: Severe rd8 and dysplasia in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; LEFT EYE: Moderate rd8 and dysplasia,
Ophthalmoscope Observation: Both eyes some opacity (difficult to focus).; RIGHT EYE: Moderate rd8 and some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes ; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes ; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Severe rd8 in both eyes,
Ophthalmoscope Observation: Severe rd8 in both eyes; LEFT EYE:,
Ophthalmoscope Observation: Severe rd8 in both eyes; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: LEFT EYE: Severe rd8,
Ophthalmoscope Observation: RIGHT EYE: Severe rd8, hyaloid present (retinal obstuction), opacity present

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes severe rd8.,
Ophthalmoscope Observation: Both eyes severe rd8.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes severe rd8.; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; LEFT EYE:,
Ophthalmoscope Observation: Both eyes moderate rd8 and some lens opacity (difficult to focus).; RIGHT EYE:

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; LEFT EYE: Severe rd8.,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus).; RIGHT EYE: Moderate rd8.

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; LEFT EYE: Moderate dysplasia,
Ophthalmoscope Observation: Some rd8 and lens opacity in both eyes; RIGHT EYE: Some dysplasia

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; LEFT EYE: Severe rd8,
Ophthalmoscope Observation: Mouse had difficultly with ketamine - restless; difficult to image.; RIGHT EYE: Severe rd8

57 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; LEFT EYE:,
Ophthalmoscope Observation: Both eyes some rd8. Mouse with rapid breathing, difficult to image.; RIGHT EYE:

58 weeks old

Rttnem1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes.,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; LEFT EYE:,
Ophthalmoscope Observation: Hard to focus. Some rd8 in both eyes. ; RIGHT EYE:

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