Gross Pathology and Tissue Collection: Images

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

15 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.; brain - normal, There is homorrahage damage on the area of under the brain stem. due to cervical dislocation slightly.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; Inguinal lymph nodes were enlarged (1.5x3mm); lymph nodes - enlarged lymph nodes, area=1.5x3, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; Inguinal lymph nodes were enlarged (1.5x3mm); lymph nodes - enlarged lymph nodes, area=1.5x3, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view

15 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.; brain - normal, There is homorrahage damage on the area of under the brain stem. due to cervical dislocation slightly.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; heart - abnormal heart position or orientation, heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery; liver - normal, largest lobe on right side; pancreas - normal, on right side; spleen - normal, on right side; stomach - normal, on right side; Pathologist's comments: Fi...,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): lung; Internal view of lung and heart; right lung had one lobe and left lung had 4 lobes,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; heart - abnormal heart position or orientation, heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery; liver - normal, largest lobe on right side; pancreas - normal, on right side; spleen - normal, on right side; stomach - normal, on right side; Pathologist's comments: Fi...,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): lung; Internal view of lung and heart; right lung had one lobe and left lung had 4 lobes,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Lung: MP:0002169,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; heart - abnormal heart position or orientation, heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery; liver - normal, largest lobe on right side; pancreas - normal, on right side; spleen - normal, on right side; stomach - normal, on right side; Pathologist's comments: Fi...,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): lung; Internal view of lung and heart; right lung had one lobe and left lung had 4 lobes,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - normal, largest lobe on right side; lung - normal, right lung has one lobe and left lung has 4 lobes; pancreas - normal, on right side; stomach - normal, on right side,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): spleen; Internal view of spleen on right side; on right side,
Comments (in English): heart; Internal view of situs inversus heart; heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney is higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Skin: MP:0002060,
Skin: PATO:0000322,
Skin: PATO:0000627,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; testis - normal, subcutaneous red clot attached,
Comments (in English): Lateral view,
Comments (in English): skin; Internal view of red subcutaneous lesion; subcutaneously,
Comments (in English): Internal view

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; testis - normal, subcutaneous red clot attached,
Comments (in English): Lateral view,
Comments (in English): skin; Internal view of red subcutaneous lesion; subcutaneously,
Comments (in English): Internal view

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Spleen: MP:0002169,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - normal, largest lobe on right side; lung - normal, right lung has one lobe and left lung has 4 lobes; pancreas - normal, on right side; stomach - normal, on right side,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): spleen; Internal view of spleen on right side; on right side,
Comments (in English): heart; Internal view of situs inversus heart; heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney is higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Heart: MP:0006065,
Comments (in English): Penis was short and skin around penis was red. There was hard nodule under penis . Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lung - abnormal lung morphology, 4 lobes for left and one lobe for right; lymph nodes - enlarged lymph nodes, area=4x2, inguinal L.N.; skin - abnormal skin morphology, area=5x4, subcutaneous lesion on left inguinal area; Pathologist's comments: There might be damage on lungs and heart due to manipulation during necropsy while the tester tried ...,
Comments (in English): Lateral view,
Comments (in English): penis; ventral view of short penis,
Comments (in English): Internal view,
Comments (in English): heart; Internal view of haert and lungs; located on right side on thoracic cavity

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Penis was short and skin around penis was red. There was hard nodule under penis . Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lung - abnormal lung morphology, 4 lobes for left and one lobe for right; lymph nodes - enlarged lymph nodes, area=4x2, inguinal L.N.; skin - abnormal skin morphology, area=5x4, subcutaneous lesion on left inguinal area; Pathologist's comments: There might be damage on lungs and heart due to manipulation during necropsy while the tester tried ...,
Comments (in English): Lateral view,
Comments (in English): penis; ventral view of short penis,
Comments (in English): Internal view,
Comments (in English): heart; Internal view of haert and lungs; located on right side on thoracic cavity

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - normal, largest lobe on right side; lung - normal, right lung has one lobe and left lung has 4 lobes; pancreas - normal, on right side; stomach - normal, on right side,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): spleen; Internal view of spleen on right side; on right side,
Comments (in English): heart; Internal view of situs inversus heart; heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney is higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Kidney: MP:0002169,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - normal, largest lobe on right side; lung - normal, right lung has one lobe and left lung has 4 lobes; pancreas - normal, on right side; stomach - normal, on right side,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): spleen; Internal view of spleen on right side; on right side,
Comments (in English): heart; Internal view of situs inversus heart; heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney is higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Kidney: MP:0002169,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; heart - abnormal heart position or orientation, heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery; liver - normal, largest lobe on right side; pancreas - normal, on right side; spleen - normal, on right side; stomach - normal, on right side; Pathologist's comments: Fi...,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): lung; Internal view of lung and heart; right lung had one lobe and left lung had 4 lobes,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Heart: MP:0006065,
Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; liver - normal, largest lobe on right side; lung - normal, right lung has one lobe and left lung has 4 lobes; pancreas - normal, on right side; stomach - normal, on right side,
Comments (in English): Lateral view,
Comments (in English): Internal view,
Comments (in English): spleen; Internal view of spleen on right side; on right side,
Comments (in English): heart; Internal view of situs inversus heart; heart situs inversus. Right ventricle had thicker wall and connected aorta. Left ventricle had thinner wall and connected pulmonary artery,
Comments (in English): kidney; Internal view of kidney with left kidney sitting more cranially than right one; left kidney is higher than right one

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Penis was short and skin around penis was red. There was hard nodule under penis . Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lung - abnormal lung morphology, 4 lobes for left and one lobe for right; lymph nodes - enlarged lymph nodes, area=4x2, inguinal L.N.; skin - abnormal skin morphology, area=5x4, subcutaneous lesion on left inguinal area; Pathologist's comments: There might be damage on lungs and heart due to manipulation during necropsy while the tester tried ...,
Comments (in English): Lateral view,
Comments (in English): penis; ventral view of short penis,
Comments (in English): Internal view,
Comments (in English): heart; Internal view of haert and lungs; located on right side on thoracic cavity

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; testis - normal, subcutaneous red clot attached,
Comments (in English): Lateral view,
Comments (in English): skin; Internal view of red subcutaneous lesion; subcutaneously,
Comments (in English): Internal view

16 weeks old

Lrrc56^em1(IMPC)Tcp homozygote

Comments (in English): Penis was short and skin around penis was red. There was hard nodule under penis . Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; lung - abnormal lung morphology, 4 lobes for left and one lobe for right; lymph nodes - enlarged lymph nodes, area=4x2, inguinal L.N.; skin - abnormal skin morphology, area=5x4, subcutaneous lesion on left inguinal area; Pathologist's comments: There might be damage on lungs and heart due to manipulation during necropsy while the tester tried ...,
Comments (in English): Lateral view,
Comments (in English): penis; ventral view of short penis,
Comments (in English): Internal view,
Comments (in English): heart; Internal view of haert and lungs; located on right side on thoracic cavity