Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia; RIGHT EYE: Crystallized debris, tiny hyaloid present, slight molten patches, early blood vessels branching, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia; RIGHT EYE: Crystallized debris, tiny hyaloid present, slight molten patches, early blood vessels branching, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity, slight debris, slightly early blood vessel branching; LEFT EYE: Slight dysplasia, blood vessels crossing and early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, early blood vessel branching, some dysplasia; LEFT EYE: Some lens opacity, slight corneal opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE: Slightly early blood vessel branching; LEFT EYE: Early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, early blood vessel branching, some dysplasia; LEFT EYE: Some lens opacity, slight corneal opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching; RIGHT EYE: Hyaloid present, crystallized debris, slight dysplasia, blood vessels crossing; LEFT EYE: Some bright dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Hyaloid present, some hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity, slight debris, slightly early blood vessel branching; LEFT EYE: Slight dysplasia, blood vessels crossing and early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE: Slightly early blood vessel branching; LEFT EYE: Early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, some hemorrhage.; LEFT EYE: Some lens opacity, small crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Hyaloid present, some hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Small crystallized debris, slight lens opacity, blood vessel crossing, some dysplasia; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Hyaloid present, some hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia; RIGHT EYE: Crystallized debris, tiny hyaloid present, slight molten patches, early blood vessels branching, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Small crystallized debris, slight lens opacity, blood vessel crossing, some dysplasia; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia; RIGHT EYE: Some debris (difficult to focus), blood vessels crossing and early branching; LEFT EYE: Tiny hyaloid present, slight corneal opacity,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, early vessel branching ; RIGHT EYE: Slight hemorrhaging, some lens opacity ; LEFT EYE: Some debris, moderate hemorrhaging,
Ophthalmoscope Observation: Both eyes some rd8, early vessel branching

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia; RIGHT EYE: Some debris (difficult to focus), blood vessels crossing and early branching; LEFT EYE: Tiny hyaloid present, slight corneal opacity,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, early vessel branching ; RIGHT EYE: Slight hemorrhaging, some lens opacity ; LEFT EYE: Some debris, moderate hemorrhaging,
Ophthalmoscope Observation: Both eyes some rd8, early vessel branching

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching; RIGHT EYE: Hyaloid present, crystallized debris, slight dysplasia, blood vessels crossing; LEFT EYE: Some bright dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE: Slightly early blood vessel branching; LEFT EYE: Early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity, slight debris, slightly early blood vessel branching; LEFT EYE: Slight dysplasia, blood vessels crossing and early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, early vessel branching ; RIGHT EYE: Slight hemorrhaging, some lens opacity ; LEFT EYE: Some debris, moderate hemorrhaging,
Ophthalmoscope Observation: Both eyes some rd8, early vessel branching

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging ; RIGHT EYE: Hyaloid present, slight early vessel branching, some lens opacity ( difficult to focus), slight dysplasia ; LEFT EYE: Slight debris, vessel crossing at optic nerve, very fine vessels.,
Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some molten patches, very slight hemorrhage ; LEFT EYE: Hyaloid present, slight molten patches, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some molten patches, very slight hemorrhage ; LEFT EYE: Hyaloid present, slight molten patches, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage ; RIGHT EYE: Crystallized debris, few bright spots, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE: Slightly early blood vessel branching; LEFT EYE: Early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging ; RIGHT EYE: Hyaloid present, slight early vessel branching, some lens opacity ( difficult to focus), slight dysplasia ; LEFT EYE: Slight debris, vessel crossing at optic nerve, very fine vessels.,
Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, some hemorrhage.; LEFT EYE: Some lens opacity, small crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia; RIGHT EYE: Crystallized debris, tiny hyaloid present, slight molten patches, early blood vessels branching, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some molten patches, very slight hemorrhage ; LEFT EYE: Hyaloid present, slight molten patches, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, early blood vessel branching, some dysplasia; LEFT EYE: Some lens opacity, slight corneal opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, early blood vessel branching, some dysplasia; LEFT EYE: Some lens opacity, slight corneal opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE: Slightly early blood vessel branching; LEFT EYE: Early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, early vessel branching ; RIGHT EYE: Slight hemorrhaging, some lens opacity ; LEFT EYE: Some debris, moderate hemorrhaging,
Ophthalmoscope Observation: Both eyes some rd8, early vessel branching

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, some hemorrhage.; LEFT EYE: Some lens opacity, small crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some molten patches, very slight hemorrhage ; LEFT EYE: Hyaloid present, slight molten patches, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage ; RIGHT EYE: Crystallized debris, few bright spots, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity, slight debris, slightly early blood vessel branching; LEFT EYE: Slight dysplasia, blood vessels crossing and early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity, slight debris, slightly early blood vessel branching; LEFT EYE: Slight dysplasia, blood vessels crossing and early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging ; RIGHT EYE: Hyaloid present, slight early vessel branching, some lens opacity ( difficult to focus), slight dysplasia ; LEFT EYE: Slight debris, vessel crossing at optic nerve, very fine vessels.,
Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging ; RIGHT EYE: Hyaloid present, slight early vessel branching, some lens opacity ( difficult to focus), slight dysplasia ; LEFT EYE: Slight debris, vessel crossing at optic nerve, very fine vessels.,
Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, early blood vessel branching, some dysplasia; LEFT EYE: Some lens opacity, slight corneal opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Hyaloid present, some hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia; RIGHT EYE: Some debris (difficult to focus), blood vessels crossing and early branching; LEFT EYE: Tiny hyaloid present, slight corneal opacity,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, early vessel branching ; RIGHT EYE: Slight hemorrhaging, some lens opacity ; LEFT EYE: Some debris, moderate hemorrhaging,
Ophthalmoscope Observation: Both eyes some rd8, early vessel branching

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage ; RIGHT EYE: Crystallized debris, few bright spots, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging ; RIGHT EYE: Hyaloid present, slight early vessel branching, some lens opacity ( difficult to focus), slight dysplasia ; LEFT EYE: Slight debris, vessel crossing at optic nerve, very fine vessels.,
Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching; RIGHT EYE: Hyaloid present, crystallized debris, slight dysplasia, blood vessels crossing; LEFT EYE: Some bright dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some molten patches, very slight hemorrhage ; LEFT EYE: Hyaloid present, slight molten patches, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia; RIGHT EYE: Some debris (difficult to focus), blood vessels crossing and early branching; LEFT EYE: Tiny hyaloid present, slight corneal opacity,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, some hemorrhage.; LEFT EYE: Some lens opacity, small crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage ; RIGHT EYE: Crystallized debris, few bright spots, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, some hemorrhage.; LEFT EYE: Some lens opacity, small crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging ; RIGHT EYE: Hyaloid present, slight early vessel branching, some lens opacity ( difficult to focus), slight dysplasia ; LEFT EYE: Slight debris, vessel crossing at optic nerve, very fine vessels.,
Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Small crystallized debris, slight lens opacity, blood vessel crossing, some dysplasia; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage, blood vessel crossing and slightly early blood branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage, blood vessel crossing and slightly early blood branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia; RIGHT EYE: Crystallized debris, tiny hyaloid present, slight molten patches, early blood vessels branching, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching; RIGHT EYE: Hyaloid present, crystallized debris, slight dysplasia, blood vessels crossing; LEFT EYE: Some bright dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia; RIGHT EYE: Crystallized debris, tiny hyaloid present, slight molten patches, early blood vessels branching, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia; RIGHT EYE: Some debris (difficult to focus), blood vessels crossing and early branching; LEFT EYE: Tiny hyaloid present, slight corneal opacity,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia; RIGHT EYE: Some debris (difficult to focus), blood vessels crossing and early branching; LEFT EYE: Tiny hyaloid present, slight corneal opacity,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity, slight debris, slightly early blood vessel branching; LEFT EYE: Slight dysplasia, blood vessels crossing and early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage ; RIGHT EYE: Crystallized debris, few bright spots, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, early blood vessel branching, some dysplasia; LEFT EYE: Some lens opacity, slight corneal opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching; RIGHT EYE: Hyaloid present, crystallized debris, slight dysplasia, blood vessels crossing; LEFT EYE: Some bright dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging ; RIGHT EYE: Hyaloid present, slight early vessel branching, some lens opacity ( difficult to focus), slight dysplasia ; LEFT EYE: Slight debris, vessel crossing at optic nerve, very fine vessels.,
Ophthalmoscope Observation: Both eyes slight rd8, some hemorrhaging

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Small crystallized debris, slight lens opacity, blood vessel crossing, some dysplasia; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage, blood vessel crossing and slightly early blood branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight corneal opacity, slight debris, slightly early blood vessel branching; LEFT EYE: Slight dysplasia, blood vessels crossing and early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Small crystallized debris, slight lens opacity, blood vessel crossing, some dysplasia; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some molten patches, very slight hemorrhage ; LEFT EYE: Hyaloid present, slight molten patches, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia; RIGHT EYE: Crystallized debris, tiny hyaloid present, slight molten patches, early blood vessels branching, slight lens opacity; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, early blood vessel branching, some dysplasia; LEFT EYE: Some lens opacity, slight corneal opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, some hemorrhage.; LEFT EYE: Some lens opacity, small crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage, blood vessel crossing and slightly early blood branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching; RIGHT EYE: Hyaloid present, crystallized debris, slight dysplasia, blood vessels crossing; LEFT EYE: Some bright dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia; RIGHT EYE: Some debris (difficult to focus), blood vessels crossing and early branching; LEFT EYE: Tiny hyaloid present, slight corneal opacity,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage ; RIGHT EYE: Crystallized debris, few bright spots, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, some hemorrhage

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Hyaloid present, some hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Some molten patches, very slight hemorrhage ; LEFT EYE: Hyaloid present, slight molten patches, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Small crystallized debris, slight lens opacity, blood vessel crossing, some dysplasia; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Hyaloid present, some hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, early vessel branching ; RIGHT EYE: Slight hemorrhaging, some lens opacity ; LEFT EYE: Some debris, moderate hemorrhaging,
Ophthalmoscope Observation: Both eyes some rd8, early vessel branching

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage, blood vessel crossing and slightly early blood branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching; RIGHT EYE: Hyaloid present, crystallized debris, slight dysplasia, blood vessels crossing; LEFT EYE: Some bright dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, early blood vessels branching

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia; RIGHT EYE: Slightly early blood vessel branching; LEFT EYE: Early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).; RIGHT EYE: Slight hemorrhage ; LEFT EYE: Hyaloid present, some hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, some dysplasia. Restless mouse (difficult to image).

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage, blood vessel crossing and slightly early blood branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

14 weeks old

Col28a1em1(IMPC)Tcp homozygote

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, very slight hemorrhage ; LEFT EYE: Corneal opacity, some lens opacity, slight hemorrhage,
Ophthalmoscope Observation: Both eyes hyaloid present, crystallized debris, early blood vessel branching, some rd8, slight dysplasia

15 weeks old

Col28a1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia; RIGHT EYE: Some debris (difficult to focus), blood vessels crossing and early branching; LEFT EYE: Tiny hyaloid present, slight corneal opacity,
Ophthalmoscope Observation: Both eyes slight lens opacity, some hemorrhage, some rd8, some dysplasia

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