Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus); LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Large massive hyaloid obstructing the optic disc (difficult to focus and image),
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE:

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Large massive hyaloid obstructing the optic disc (difficult to focus and image),
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE:

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus); LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Large massive hyaloid obstructing the optic disc (difficult to focus and image),
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE:

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Large massive hyaloid obstructing the optic disc (difficult to focus and image),
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE:

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Large massive hyaloid obstructing the optic disc (difficult to focus and image),
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE:

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; LEFT EYE: Slight dysplasia, lesion / abnormal retinal pigmentation present,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), some rd8 ; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes hyaloid present, blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Slight lens opacity. blood vessel slightly early branching, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, blood vessel early branching, some rd8; RIGHT EYE: Hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; LEFT EYE: Some lens opacity, hyaloid present, crystallized debris, blood vessel crossing,
Ophthalmoscope Observation: Both eyes difficult to focus, blood vessel early branching, some rd8; RIGHT EYE: Slight lens opacity, slight dysplasia

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, crystallized debris, blood vessel crossing near optic disc,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Some lens opacity (difficult to focus), hyaloid present

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus); LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8 and slight dysplasia.; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Blood vessel slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Hyaloid present, blood vessel early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus); LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Large massive hyaloid obstructing the optic disc (difficult to focus and image),
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE:

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE: Large massive hyaloid obstructing the optic disc (difficult to focus and image),
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE:

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus); LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus); LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; LEFT EYE: Some lens opacity, hyaloid present, blood vessel crossing, slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8; RIGHT EYE: Slight lens opacity (difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; LEFT EYE: Some lens opacity, blood vessel early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, verys light hemorrhage; RIGHT EYE: Slight lens opacity, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus), blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel crossing and slightly early branching, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, blood vessel slightly early branching

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; LEFT EYE: Slight hemorrhage.,
Ophthalmoscope Observation: Both eyes some lens opacity, some rd8, blood vessel early branching; RIGHT EYE: Hyaloid present, small crystallized debris

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus); LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus); LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris and large hyaloid (obstructing the optic disc, difficult to focus)

14 weeks old

Hmbox1em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Blood vessel slightly early branching

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