Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Difficult to focus. Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; LEFT EYE: Tiny hyaloid. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; LEFT EYE: Tiny hyaloid. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Difficult to focus. Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Right eye missing, retina no data; LEFT EYE: Slight lens opacity. Crystallized debris present. Some rd8, slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Crystallized debris present. Some rd8, slight hemorrhage

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; LEFT EYE: Tiny hyaloid. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Difficult to focus. Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Difficult to focus. Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Difficult to focus. Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Right eye missing, retina no data; LEFT EYE: Slight lens opacity. Crystallized debris present. Some rd8, slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Crystallized debris present. Some rd8, slight hemorrhage

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; LEFT EYE: Small lesion on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; LEFT EYE: Small lesion on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; LEFT EYE: Tiny hyaloid. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; LEFT EYE: Tiny hyaloid. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: RIGHT EYE: Right eye missing, retina no data; LEFT EYE: Slight lens opacity. Crystallized debris present. Some rd8, slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Slight lens opacity. Crystallized debris present. Some rd8, slight hemorrhage

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Some lens opacity. Hyaloid present. Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Slight lens opacity. Blood vessel slightly early branching.

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; LEFT EYE: Small lesion on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; LEFT EYE: Tiny hyaloid. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Slight lens opacity

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; LEFT EYE: Small lesion on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; LEFT EYE: Small lesion on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; LEFT EYE: Tiny hyaloid. Blood vessel slightly early branching.,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Difficult to focus. Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes very slight lens opacity, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity. Slight rd8, slight hemorrhage; RIGHT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Multiple hyaloid present, very slight lens opacity, blood vessel slightly early branching

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhaging and dysplasia.; RIGHT EYE: Some lens opacity (difficult to focus).

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; RIGHT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight rd8, hemorrhaging, dysplasia and lens opacity.; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; LEFT EYE: Small lesion on retina,
Ophthalmoscope Observation: Both eyes slight lens opacity, difficult to focus. Slight rd8, slight hemorrhage; RIGHT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; LEFT EYE:

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; LEFT EYE: Crystallized debris, some rd8, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, blood vessel early branching and crossing, slight hemorrhage; RIGHT EYE: Slight rd8

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; RIGHT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8, slight lens opacity ; LEFT EYE:

14 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage ; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; LEFT EYE: Multiple tiny hyaloid present. Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8; RIGHT EYE: Hyaloid and crystallized debris present (difficult to focus and image). Slight hemorrhage

15 weeks old

Tm9sf2em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Blood vessel crossing,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE: Blood vessel early branching

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