Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Blood vessel slightly early branching. Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image); LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; LEFT EYE: Hyaloid present

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching and crossing near optic disc,
Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; RIGHT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image); LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; LEFT EYE: Hyaloid present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; RIGHT EYE: Hyaloid and crystallized debris present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; RIGHT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Blood vessel slightly early branching. Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image); LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; LEFT EYE: Hyaloid present

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; RIGHT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image); LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; LEFT EYE: Hyaloid present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image); LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; LEFT EYE: Hyaloid present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image); LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; LEFT EYE: Hyaloid present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Blood vessel slightly early branching. Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; RIGHT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; RIGHT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching and crossing near optic disc,
Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; RIGHT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; RIGHT EYE: Big hyaloid and crystallized debris (obstruct part of retina, difficult to focus and image). Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; RIGHT EYE: Big hyaloid and crystallized debris (obstruct part of retina, difficult to focus and image). Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; RIGHT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; RIGHT EYE: Hyaloid and crystallized debris present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; RIGHT EYE: Big hyaloid and crystallized debris (obstruct part of retina, difficult to focus and image). Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; RIGHT EYE: Big hyaloid and crystallized debris (obstruct part of retina, difficult to focus and image). Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; RIGHT EYE: Hyaloid and crystallized debris present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; RIGHT EYE: Hyaloid and crystallized debris present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image); LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; LEFT EYE: Hyaloid present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; RIGHT EYE: Hyaloid and crystallized debris present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Blood vessel slightly early branching. Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching and crossing near optic disc,
Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; RIGHT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; RIGHT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; RIGHT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; RIGHT EYE: Big hyaloid and crystallized debris (obstruct part of retina, difficult to focus and image). Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching and crossing near optic disc,
Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; RIGHT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; RIGHT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching and crossing near optic disc,
Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; RIGHT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching and crossing near optic disc,
Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; RIGHT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; RIGHT EYE: Big hyaloid and crystallized debris (obstruct part of retina, difficult to focus and image). Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; RIGHT EYE: Big hyaloid and crystallized debris (obstruct part of retina, difficult to focus and image). Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Blood vessel crossing near optic disc. Some rd8, slight hemorrhage, very slight molten patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching and crossing near optic disc,
Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; RIGHT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Blood vessel slightly early branching. Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; RIGHT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching and crossing near optic disc,
Ophthalmoscope Observation: Both eyes slight lens opacity. Hyaloid and crystallized debris (difficult to focus). Some rd8, some dysplasia, abnormal white retinal patches; RIGHT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; RIGHT EYE: Hyaloid and crystallized debris present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Blood vessel slightly early branching. Slight dysplasia, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; RIGHT EYE: Hyaloid and crystallized debris present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, some molten patches; LEFT EYE:

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; LEFT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage, very slight molten patches; RIGHT EYE: Some dysplasia

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; LEFT EYE: Some molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, some rd8, slight dysplasia; RIGHT EYE: Slight molten patches

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; RIGHT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Crystallized debris (obstruct part of retina, difficult to focus and image). Some rd8; RIGHT EYE: Slight corneal opacity. Big hyaloid present. Slight dysplasia, abnormal white retinal patches

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; RIGHT EYE: Slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, some molten patches, some rd8 ; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image); LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; RIGHT EYE: Slight corneal opacity (difficult to focus and image),
Ophthalmoscope Observation: Both eyes some lens opacity, crystallized debris, some rd8, slight hemorrhage, molten patches and abnormal retinal pigmentation; LEFT EYE: Hyaloid present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, blood vessel slightly early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight hemorrhage, some rd8, slight hemorrhage; RIGHT EYE: Slight lens opacity, very small lesion

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some molten patches, some rd8, ; RIGHT EYE: Very slight lens opacity, lesion / abnormal pigmentation present

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; RIGHT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, some abnormal white retinal patches; LEFT EYE:

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity. Some rd8, slight dysplasia, abnormal white retinal patches; RIGHT EYE: Hyaloid present. Blood vessel crossing near optic disc

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches

15 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; LEFT EYE: Blood vessel early branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight dysplasia, some rd8; RIGHT EYE: Very slight molten patches

14 weeks old

Xpo4em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; LEFT EYE: Slight lens opacity, multiple small hyaloid, slight hemorrhage,
Ophthalmoscope Observation: Both eyes some rd8 ; RIGHT EYE: Very slight lens opacity, small crystallized debris, blood vessel early branching

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