Histopath Information for ubiquitin specific peptidase 42 | International Mouse Phenotyping Consortium

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Histopathology data for Usp42

Home Genes Usp42 Histopathology

Score Definitions

Severity Score:

0 = Normal,
1 = Mild (observation barely perceptible and not believed to have clinical significance),
2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical),
3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor),
4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.

Zyg	Sex	Mouse	Tissue	MPATH Process Term	Severity Score	Significance Score	MPATH Diagnostic	PATO Descriptor	Free Text
HOM	M	#3	Spleen [MA:0000141]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Spinal cord [MA:0000216]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Esophagus [MA:0000352]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Skeletal muscle [MA:0003148]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Liver [MA:0000358]	lipid deposition [MPATH:42] lipid deposition [MPATH:42] lipid deposition [MPATH:42] lipid deposition [MPATH:42]	3 3 3 3	0 0 0 0		distributed distributed distributed distributed	Hepatic lipisosis Hepatic lipisosis Hepatic lipisosis Hepatic lipisosis
HOM	M	#3	Lymph node [MA:0000139]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Skeletal muscle [MA:0003148]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Kidney [MA:0000368]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Esophagus [MA:0000352]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Trachea [MA:0000441]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Sternum [MA:0001331]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Ovary [MA:0000384]	hyperplasia [MPATH:134] hyperplasia [MPATH:134]	2 2	0 0			Corpus luteum hyperplasia Corpus luteum hyperplasia
HOM	M	#4	Seminal vesicle [MA:0000410]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Brain [MA:0000168]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Gall bladder [MA:0000356]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Gall bladder [MA:0000356]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Brain [MA:0000168]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Uterus [MA:0000389]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Thyroid	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Gall bladder [MA:0000356]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Spleen [MA:0000141]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Heart [MA:0000072]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Liver [MA:0000358]	lipid deposition [MPATH:42] lipid deposition [MPATH:42]	3 3	0 0		distributed distributed	Hepatic lipisosis Hepatic lipisosis
HOM	M	#3	Skeletal muscle [MA:0003148]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Trigeminal V nerve [MA:0001100]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Prostate	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Eye with optic nerve	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Thymus [MA:0000142]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Brown adipose tissue [MA:0000057]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Brain [MA:0000168]	process of degenerative change [MPATH:14] process of degenerative change [MPATH:14]	1 1	0 0	hydrocephalus MPATH:639 hydrocephalus MPATH:639		hydrocephalus, lateral ventricle hydrocephalus, lateral ventricle
HOM	F	#2	Spleen [MA:0000141]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Liver [MA:0000358]	lipid deposition [MPATH:42] lipid deposition [MPATH:42]	3 3	0 0		distributed distributed	Hepatic lipisosis Hepatic lipisosis
HOM	F	#2	Brown adipose tissue [MA:0000057]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Eye with optic nerve	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Ovary [MA:0000384]	hyperplasia [MPATH:134] hyperplasia [MPATH:134]	3 3	0 0
HOM	F	#2	Lymph node [MA:0000139]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Thyroid	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Adrenal gland [MA:0000116]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Lymph node [MA:0000139]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Thyroid	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Brown adipose tissue [MA:0000057]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Eye with optic nerve	hyperplasia [MPATH:134] hyperplasia [MPATH:134]	2 2	0 0		focally extensive focally extensive	Iridial hyperplasia and anterior synechia Iridial hyperplasia and anterior synechia
HOM	M	#4	Trigeminal V nerve [MA:0001100]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Sternum [MA:0001331]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Thymus [MA:0000142]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Tibia [MA:0001361]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Femur [MA:0001359]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Knee joint [MA:0000471]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Bone marrow [MA:0000134]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Mammary gland [MA:0000145]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Stomach [MA:0000353]	inflammation [MPATH:212] inflammation [MPATH:212]	1 1	0 0		multi-localised subacute multi-localised subacute	Gastritis, suppurative Gastritis, suppurative
HOM	M	#3	Trachea [MA:0000441]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Brown adipose tissue [MA:0000057]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Spinal cord [MA:0000216]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Heart [MA:0000072]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Small intestine [MA:0000337]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Adrenal gland [MA:0000116]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Femur [MA:0001359]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Spleen [MA:0000141]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Urinary bladder [MA:0000380]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Kidney [MA:0000368]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Large intestine [MA:0000333]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Testes	process of degenerative change [MPATH:14] process of degenerative change [MPATH:14]	3 3	0 0		distributed distributed	Testicular degeneration and Testicular atrophy and lack of spermatogenesis. Testicular degeneration and Testicular atrophy and lack of spermatogenesis.
HOM	F	#2	Sternum [MA:0001331]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Skeletal muscle [MA:0003148]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Tibia [MA:0001361]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Salivary gland [MA:0000346]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Pancreas [MA:0000120]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Large intestine [MA:0000333]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Stomach [MA:0000353]	inflammation [MPATH:212] inflammation [MPATH:212] inflammation [MPATH:212] inflammation [MPATH:212]	1 1 1 1	0 0 0 0		multi-localised subacute multi-localised subacute multi-localised subacute multi-localised subacute	Gastritis, suppurative Gastritis, suppurative Gastritis, suppurative Gastritis, suppurative
HOM	F	#2	Pancreas [MA:0000120]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Lung [MA:0000415]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Femur [MA:0001359]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Kidney [MA:0000368]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Heart [MA:0000072]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Salivary gland [MA:0000346]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Urinary bladder [MA:0000380]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Tibia [MA:0001361]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4
HOM	F	#2	Trachea [MA:0000441]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Stomach [MA:0000353]	inflammation [MPATH:212] inflammation [MPATH:212]	1 1	0 0		subacute multi-localised subacute multi-localised	Gastritis, suppurative Gastritis, suppurative
HOM	M	#3	Adrenal gland [MA:0000116]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Pancreas [MA:0000120]	inflammation [MPATH:212] inflammation [MPATH:212]	1 1	0 0		localized acute localized acute	Necrosuppurative pancreatitis, focal Necrosuppurative pancreatitis, focal
HOM	M	#3
HOM	M	#3	Testes	process of degenerative change [MPATH:14] process of degenerative change [MPATH:14]	3 3	0 0		distributed distributed	Testicular degeneration and Testicular atrophy and lack of spermatogenesis. Testicular degeneration and Testicular atrophy and lack of spermatogenesis.
HOM	M	#3	Urinary bladder [MA:0000380]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Small intestine [MA:0000337]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Trigeminal V nerve [MA:0001100]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Bone marrow [MA:0000134]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Pancreas [MA:0000120]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Salivary gland [MA:0000346]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Bone marrow [MA:0000134]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Eye with optic nerve	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Mammary gland [MA:0000145]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Skin [MA:0000151]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Small intestine [MA:0000337]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Bone marrow [MA:0000134]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Large intestine [MA:0000333]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Trigeminal V nerve [MA:0001100]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Skin [MA:0000151]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Skin [MA:0000151]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Prostate	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Spinal cord [MA:0000216]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Liver [MA:0000358]	lipid deposition [MPATH:42] lipid deposition [MPATH:42]	3 3	0 0		distributed distributed	Hepatic lipisosis Hepatic lipisosis
HOM	F	#1	Lung [MA:0000415]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Thymus [MA:0000142]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Brain [MA:0000168]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Thyroid	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Seminal vesicle [MA:0000410]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Esophagus [MA:0000352]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Skin [MA:0000151]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Lymph node [MA:0000139]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Large intestine [MA:0000333]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Heart [MA:0000072]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Small intestine [MA:0000337]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Adrenal gland [MA:0000116]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Spinal cord [MA:0000216]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Knee joint [MA:0000471]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Tibia [MA:0001361]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Thymus [MA:0000142]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Stomach [MA:0000353]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Sternum [MA:0001331]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Kidney [MA:0000368]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Knee joint [MA:0000471]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Lung [MA:0000415]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Gall bladder [MA:0000356]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Urinary bladder [MA:0000380]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Femur [MA:0001359]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#1	Esophagus [MA:0000352]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Knee joint [MA:0000471]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Trachea [MA:0000441]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#4	Salivary gland [MA:0000346]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	M	#3	Lung [MA:0000415]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0
HOM	F	#2	Uterus [MA:0000389]	normal [MPATH:458] normal [MPATH:458]	0 0	0 0

Associated histopathology images

Usp42
homozygote
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MA:0000411 testis
Usp42^{tm2a(EUCOMM)Wtsi}
experimental