Gene: Chrna7

Order

Name cholinergic receptor, nicotinic, alpha polypeptide 7

Synonyms
  • alpha7-nAChR
  • alpha7 nicotinic receptor
  • Acra7
  • alpha7

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:99779    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Chrna7

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Chrna7 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased circulating HDL cholesterol level Chrna7tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.36E-5
abnormal bone structure Chrna7tm1b(EUCOMM)Hmgu HOM Female Male postnatal 2.5E-5
increased circulating cholesterol level Chrna7tm1b(EUCOMM)Hmgu HOM Female Male postnatal 4.98E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No (2/2)
Esophagus 2 No (7/415)
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No (2/2)
Oral epithelium 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
Vascular system 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    digestive system
    nervous system
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (6/485) (2/2)
Ear 1 (1/485)
Embryo 1 (1/485) (2/2)
Eye 1 (1/485) (1/2)
Foot 1 (1/485) (2/2)
Forebrain 1 (1/485) (1/2)
Forelimb 1 (1/485) (1/2)
Hand 1 (1/485) (2/2)
Head 1 (5/485) (2/2)
Heart 1 (1/485)
Hindbrain 1 (6/485) (1/2)
Hindlimb 1 (1/485) (1/2)
Liver 1 (1/485)
Lung 1 (1/485)
Mandibular process 1 (1/485)
Maxillary process 1 (1/485)
Midbrain 1 (1/485) (2/2)
Oral cavity 1 (1/485)
Skin 1 (1/485)
Tail 1 (1/485) (2/2)
Tail somite 1 (1/485)


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    9 Images
  • Adult LacZ: LacZ Images Wholemount
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Chrna7tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Chrna7tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Chrna7tm3a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Chrna7tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene