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Gene: Zfp3 MGI:99177

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
zinc finger protein 3
Synonyms:
Zfp-3,  Fnp-1

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zfp3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp3.

There are 10 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation. European journal of immunology (June 2023) Zfp362tm1c(EUCOMM)Wtsi Zfp362tm1a(EUCOMM)Wtsi 37366299
Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (November 2022) Zfp384tm1c(EUCOMM)Hmgu Zfp384tm1a(EUCOMM)Hmgu 36321253
Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung Fibrosis. Cells (September 2022) Zfp365tm1a(KOMP)Wtsi PMC9497065
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Zfp341tm1a(KOMP)Wtsi Zfp365tm1a(KOMP)Wtsi Zfp383em1(IMPC)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Zfp341tm1a(KOMP)Wtsi Zfp365tm1a(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Zfp341tm1a(KOMP)Wtsi Zfp365tm1a(KOMP)Wtsi Zfp367tm1a(KOMP)Wtsi Zfp367tm1a(KOMP)Wtsi PMC6671969
ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer. Nature communications (April 2019) Zfp30tm3e(EUCOMM)Hmgu PMC6472429
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Zfp341tm1a(KOMP)Wtsi Zfp365tm1a(KOMP)Wtsi Zfp367tm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Zfp341tm1a(KOMP)Wtsi Zfp365tm1a(KOMP)Wtsi PMC5827107
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PloS one (July 2017) Zfp346tm1.1(KOMP)Vlcg PMC5503261

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MGI Allele Allele Type Produced
Zfp3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Zfp3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Zfp3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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