Gene: Xbp1

Order

Name X-box binding protein 1

Synonyms
  • TREB-5
  • D11Ertd39e
  • XBP-1
  • TREB5

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:98970    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Xbp1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Xbp1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Xbp1tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Xbp1tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
vertebral fusion Xbp1tm1a(EUCOMM)Wtsi HET Female Male postnatal 3.68E-21
abnormal bone mineralization Xbp1tm1a(EUCOMM)Wtsi HET Female Male postnatal 8.14E-8
increased grip strength Xbp1tm1a(EUCOMM)Wtsi HET Female Male postnatal 7.68E-7
increased lean body mass Xbp1tm1a(EUCOMM)Wtsi HET Female Male postnatal 3.67E-5
increased mean corpuscular volume Xbp1tm1b(EUCOMM)Wtsi HET Female Male postnatal 3.84E-5
decreased IgG1 level Xbp1tm1a(EUCOMM)Wtsi HET Male postnatal 4.21E-5
abnormal bone structure Xbp1tm1a(EUCOMM)Wtsi HET Female Male postnatal 4.97E-5
decreased T cell number Xbp1tm1a(EUCOMM)Wtsi HET Male postnatal 5.13E-5
decreased circulating cholesterol level Xbp1tm1a(EUCOMM)Wtsi HET Male postnatal 5.26E-5
decreased circulating triglyceride level Xbp1tm1a(EUCOMM)Wtsi HET Male postnatal 6.88E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Bone 2 No (1/539)
Brain 2 No (6/562)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393)
Oral epithelium 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (1/2)
Striatum 2 No (4/562)
Testis 2 No (4/562)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
Vascular system 2 No (1/393)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    digestive system
    trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482)
Ear 2 (1/482)
Embryo 2 (1/482)
Eye 2 (1/482)
Foot 2 (1/482)
Forebrain 2 (1/482)
Forelimb 2 (1/482)
Hand 2 (1/482)
Head 2 (5/482)
Heart 2 (1/482)
Hindbrain 2 (6/482)
Hindlimb 2 (1/482)
Liver 2 (1/482)
Lung 2 (1/482)
Mandibular process 2 (1/482)
Maxillary process 2 (1/482)
Midbrain 2 (1/482)
Oral cavity 2 (1/482)
Skin 2 (1/482)
Tail 2 (1/482)
Tail somite 2 (1/482)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    51 Images
  • Echo: M-Mode Images
    32 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    3 Images
  • X-ray: XRay Images Lateral Orientation
    38 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    24 Images
  • X-ray: XRay Images Skull Lateral Orientation
    13 Images
  • X-ray: XRay Images Forepaw
    12 Images
  • Adult LacZ: LacZ Images Wholemount
    1 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Xbp1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Xbp1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Xbp1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Xbp1tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Xbp1tm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene