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Gene: Cripto MGI:98658

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Gene Summary

Name:
cripto, EGF-CFC family member
Synonyms:
Tdgf1,  CR1

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Criptoem1(IMPC)H HOM   Early adult 0.000317

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cripto mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases predicted to be associated to Cripto by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida, Hypertelorism ORPHA:945
Holoprosencephaly 5
Syntelencephaly, Hypertelorism, Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly,... OMIM:609637
Holoprosencephaly-Caudal Dysgenesis Syndrome
Cyclopia, Proptosis, Holoprosencephaly, Hypertelorism ORPHA:2165
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydranencephaly, Hydrocephalus, Holoprosencephaly OMIM:617967
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly, Iris coloboma, Chorioretinal coloboma OMIM:611638
Solitary Median Maxillary Central Incisor
Coloboma, Cyclopia, Holoprosencephaly, Hypotelorism OMIM:147250
Distal Deletion 13Q
Encephalocele, Hypertelorism, Anencephaly, Holoprosencephaly, Iris coloboma ORPHA:1590
Pseudotrisomy 13 Syndrome
Encephalocele, Hydrocephalus, Hypotelorism, Holoprosencephaly, Cyclopia OMIM:264480
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Coloboma, Holoprosencephaly, Anterior encephalocele OMIM:601357
Hartsfield Syndrome
Encephalocele, Lobar holoprosencephaly, Hypertelorism ORPHA:2117
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Hydranencephaly, Deeply set eye, Holoprosencephaly ORPHA:2570
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Hypertelorism, Hydrocephalus, Meningocele, Anencephaly, Spinal dysraphism, Proptos... ORPHA:1908
Holoprosencephaly 11
Proptosis, Holoprosencephaly, Hypotelorism OMIM:614226
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Cyclopia, Holoprosencephaly ORPHA:990
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Thanatophoric Dysplasia Type 2
Encephalocele, Hydrocephalus, Proptosis, Holoprosencephaly ORPHA:93274
Microhydranencephaly, X-Linked
Holoprosencephaly OMIM:306990
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly ORPHA:2523
Microform Holoprosencephaly
Holoprosencephaly, Cyclopia, Iris coloboma, Hypotelorism ORPHA:280200
Holoprosencephaly-Postaxial Polydactyly Syndrome
Encephalocele, Hydrocephalus, Hypotelorism, Holoprosencephaly, Umbilical hernia, Cyclopia ORPHA:2166
Trisomy 18
Spina bifida, Hypertelorism, Anencephaly, Holoprosencephaly, Cyclopia, Iris coloboma ORPHA:3380
Holoprosencephaly
Encephalocele, Hypertelorism, Hydrocephalus, Hypotelorism, Spinal dysraphism, Deeply set eye, Bra... ORPHA:2162
Triploidy
Hypertelorism, Hydrocephalus, Meningocele, Holoprosencephaly, Iris coloboma ORPHA:3376
Holoprosencephaly 3
Cyclopia, Proptosis, Holoprosencephaly, Hypotelorism OMIM:142945
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Vissers-Bodmer Syndrome
Holoprosencephaly OMIM:619033
Holoprosencephaly 14
Alobar holoprosencephaly, Aqueductal stenosis, Hydrocephalus, Holoprosencephaly, Cyclopia OMIM:619895
16P13.11 Microdeletion Syndrome
Cyclopia, Holoprosencephaly ORPHA:261236
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Aqueductal stenosis, Hydrocephalus, Holoprosencephaly ORPHA:2182
Chromosome 3Q13.31 Deletion Syndrome
Alobar holoprosencephaly, Hypertelorism OMIM:615433
Joubert Syndrome 16
Encephalocele, Coloboma, Molar tooth sign on MRI, Hypertelorism OMIM:614465
Holoprosencephaly 2
Remnants of the hyaloid vascular system, Alobar holoprosencephaly, Hypotelorism, Proptosis, Holop... OMIM:157170
Semilobar Holoprosencephaly
Hydrocephalus, Abnormal brainstem morphology, Hypotelorism, Neural tube defect, Cyclopia ORPHA:220386
Alobar Holoprosencephaly
Hydrocephalus, Abnormal brainstem morphology, Hypotelorism, Neural tube defect, Cyclopia ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Hydrocephalus, Abnormal brainstem morphology, Hypotelorism, Neural tube defect, Cyclopia ORPHA:93926
Lobar Holoprosencephaly
Hydrocephalus, Abnormal brainstem morphology, Hypotelorism, Neural tube defect, Cyclopia ORPHA:93924
Ring Chromosome 21 Syndrome
Holoprosencephaly ORPHA:1445
Distal Monosomy 7Q36
Holoprosencephaly ORPHA:1636
1Q41Q42 Microdeletion Syndrome
Deeply set eye, Holoprosencephaly, Hypotelorism ORPHA:250999
Holoprosencephaly 7
Hypertelorism, Alobar holoprosencephaly, Hydrocephalus, Hypotelorism, Lobar holoprosencephaly, Hy... OMIM:610828
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly, Cyclopia, Iris coloboma, Hypotelorism ORPHA:3186
Lambotte Syndrome
Semilobar holoprosencephaly, Hypertelorism OMIM:245552
Joubert Syndrome 15
Molar tooth sign on MRI, Coloboma, Exencephaly OMIM:614464
Holoprosencephaly 13, X-Linked
Cyclopia, Semilobar holoprosencephaly, Alobar holoprosencephaly OMIM:301043
Chromosome 1Q41-Q42 Deletion Syndrome
Deeply set eye, Hypertelorism, Holoprosencephaly, Hypotelorism OMIM:612530
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Encephalocele, Hydrocephalus, Hypoplasia of the brainstem, Holoprosencephaly OMIM:253800
Proboscis Lateralis
Hypertelorism, Optic disc coloboma, Proptosis, Holoprosencephaly, Chorioretinal coloboma, Cyclopi... ORPHA:141099
Monosomy 18P
Holoprosencephaly ORPHA:1598
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Hydrocephalus, Holoprosencephaly, Iris coloboma ORPHA:77298
Holoprosencephaly 1
Cyclopia, Ethmocephaly, Alobar holoprosencephaly, Hypotelorism OMIM:236100
Holoprosencephaly-Craniosynostosis Syndrome
Holoprosencephaly, Hypotelorism ORPHA:2163
Meckel Syndrome 14
Occipital encephalocele, Holoprosencephaly, Hypertelorism OMIM:619879
Hydrolethalus Syndrome 2
Molar tooth sign on MRI, Hydrocephalus, Anencephaly OMIM:614120
49,Xxxxy Syndrome
Holoprosencephaly, Hypertelorism ORPHA:96264
Meckel Syndrome 13
Molar tooth sign on MRI, Occipital encephalocele OMIM:617562
Short-Rib Thoracic Dysplasia 12
Hydrocephalus, Anencephaly, Holoprosencephaly, Hypertelorism OMIM:269860
Iniencephaly
Encephalocele, Spina bifida, Myelomeningocele, Hydrocephalus, Anencephaly, Spinal dysraphism, Hol... ORPHA:63259
Agnathia-Otocephaly Complex
Holoprosencephaly OMIM:202650
Arachnoid Cyst
Encephalocele, Hydrocephalus, Holoprosencephaly ORPHA:2356
Septopreoptic Holoprosencephaly
Hypoplasia of the pons, Abnormal midbrain morphology, Ethmoidal encephalocele ORPHA:280195
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Endocrine-Cerebroosteodysplasia
Deeply set eye, Hydrocephalus, Holoprosencephaly, Hypotelorism OMIM:612651
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
Hypertelorism, Lobar holoprosencephaly, Hypotelorism OMIM:614701
Holoprosencephaly 4
Semilobar holoprosencephaly, Hypotelorism OMIM:142946
Microtia-Anotia
Holoprosencephaly OMIM:600674
Chromosome 13Q14 Deletion Syndrome
Hypotelorism, Holoprosencephaly, Chorioretinal coloboma, Umbilical hernia, Iris coloboma OMIM:613884
Pancreatic Agenesis-Holoprosencephaly Syndrome
Semilobar holoprosencephaly, Holoprosencephaly, Hypotelorism ORPHA:556955
Jacobsen Syndrome
Hypertelorism, Hydrocephalus, Holoprosencephaly, Chorioretinal coloboma, Iris coloboma OMIM:147791
Microtia
Holoprosencephaly ORPHA:83463
Halperin-Birk Syndrome
Umbilical hernia, Semilobar holoprosencephaly OMIM:618651
Steinfeld Syndrome
Holoprosencephaly, Retinal coloboma, Iris coloboma OMIM:184705
Meckel Syndrome, Type 4
Encephalocele, Hydrocephalus, Meningocele, Anencephaly, Molar tooth sign on MRI OMIM:611134
Orofaciodigital Syndrome Xiv
Occipital encephalocele, Optic disc coloboma, Retinal coloboma, Holoprosencephaly, Molar tooth si... OMIM:615948
Isolated Exencephaly
Proptosis, Holoprosencephaly ORPHA:563612
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Olivopontocerebellar hypoplasia, Hypoplasia of the pons, Hypotelorism, Lobar holoprosencephaly, P... ORPHA:468631
Hartsfield Syndrome
Hypertelorism, Alobar holoprosencephaly, Lobar holoprosencephaly, Hypotelorism, Semilobar holopro... OMIM:615465
Meckel Syndrome
Encephalocele, Hypertelorism, Hydrocephalus, Anencephaly, Lobar holoprosencephaly ORPHA:564
Smith-Lemli-Opitz Syndrome
Holoprosencephaly, Proptosis, Iris coloboma, Hypertelorism ORPHA:818
Pallister-Hall Syndrome
Holoprosencephaly OMIM:146510
Monosomy 13Q14
Holoprosencephaly, Iris coloboma, Hypertelorism ORPHA:1587
Charge Syndrome
Hypertelorism, Aqueductal stenosis, Holoprosencephaly, Chorioretinal coloboma, Iris coloboma ORPHA:138
Holoprosencephaly 9
Hydrocephalus, Holoprosencephaly, Hypotelorism OMIM:610829
Mosaic Variegated Aneuploidy Syndrome
Holoprosencephaly ORPHA:1052
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Semilobar holoprosencephaly, Lobar holoprosencephaly, Hypotelorism OMIM:618500
Smith-Lemli-Opitz Syndrome
Hydrocephalus, Holoprosencephaly, Hypertelorism OMIM:270400
Genitourinary And/Or Brain Malformation Syndrome
Holoprosencephaly, Hypertelorism OMIM:618820
Ring Chromosome 7 Syndrome
Holoprosencephaly, Hypotelorism ORPHA:1449
Charge Syndrome
Hypertelorism, Coloboma, Retinal coloboma, Holoprosencephaly, Umbilical hernia, Iris coloboma OMIM:214800
Townes-Brocks Syndrome 1
Umbilical hernia, Hydrocephalus, Holoprosencephaly, Chorioretinal coloboma OMIM:107480
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Deeply set eye, Semilobar holoprosencephaly, Hypotelorism OMIM:301044
Pallister-Hall Syndrome
Umbilical hernia, Holoprosencephaly, Hypertelorism ORPHA:672
Duplication Of The Pituitary Gland
Encephalocele, Abnormal midbrain morphology, Hypertelorism ORPHA:314621
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly, Hypertelorism OMIM:129900
Slc35A2-Cdg
Abnormal midbrain morphology, Atrophy/Degeneration affecting the brainstem ORPHA:356961
Adult Krabbe Disease
Abnormal pons morphology, Abnormal medulla oblongata morphology, Abnormal midbrain morphology ORPHA:206448
Combined Pituitary Hormone Deficiencies, Genetic Forms
Holoprosencephaly ORPHA:95494
Japanese Encephalitis
Abnormal pons morphology, Abnormal substantia nigra morphology, Abnormal midbrain morphology ORPHA:79139
Cerebellar-Facial-Dental Syndrome
Hypoplasia of the pons, Hypoplasia of the brainstem, Abnormal midbrain morphology ORPHA:444072
Amoebiasis Due To Free-Living Amoebae
Abnormal brainstem MRI signal intensity, Abnormal pons morphology, Abnormal medulla oblongata mor... ORPHA:68
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Abnormal midbrain morphology, Hypertelorism ORPHA:293987

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cripto

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cripto.

No publications found that use IMPC mice or data for Cripto.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Criptotm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Criptotm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Criptoem1(IMPC)H KO first allele (reporter-tagged insertion with conditional potential) Mice

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