Gene: Rpn2

Name ribophorin II

Synonyms
  • 1300012C06Rik
  • Rpn-2

Status ES CellsMice
tm1a
phenotype data available

Links MGI:98085   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Rpn2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Rpn2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Rpn2tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
increased circulating free fatty acid level Rpn2tm1a(EUCOMM)Wtsi HET Male postnatal 1.68E-8
increased circulating glycerol level Rpn2tm1a(EUCOMM)Wtsi HET Male postnatal 7.55E-7

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 8 No (5/8)
Aorta 8 No (1/562)
Blood vessel 8 No
Bone 8 No (1/539)
Brain 8 No (6/562) (8/8)
Brainstem 8 No (4/562)
Brown adipose tissue 8 No
Cartilage tissue 8 No (1/562) (5/8)
Cerebellum 8 No (4/562)
Cerebral cortex 8 No (5/562)
Eye 8 No (1/562) (2/8)
Gall bladder 8 No
Heart 8 No (3/562) (3/8)
Hippocampus 8 No (5/562)
Hypothalamus 8 No (4/562)
Kidney 8 No (20/562) (5/8)
Large intestine 8 No (12/562) (5/8)
Liver 8 No
Lower urinary tract 8 No (3/562) (4/8)
Lung 8 No (3/562) (5/8)
Lymph node 8 No (1/562)
Mammary gland 8 No
Esophagus 8 No (5/8)
Olfactory lobe 8 No
Ovary 8 No (1/562) (3/8)
Oviduct 8 No (2/562) (3/8)
Pancreas 8 No (6/562) (5/8)
Parathyroid gland 8 No (2/540) (5/8)
Peripheral nervous system 8 No (3/562) (8/8)
Peyer's patch 8 No (5/8)
Pituitary gland 8 No (1/562) (6/8)
Prostate gland 8 No (5/562) (2/8)
Skeletal muscle tissue 8 No
Skin 8 No (1/562) (5/8)
Small intestine 8 No (11/562) (5/8)
Spinal cord 8 No (3/562) (8/8)
Spleen 8 No (4/562)
Stomach 8 No (9/562) (5/8)
Striatum 8 No (4/562)
Testis 8 No (4/562) (4/8)
Thymus 8 No (5/8)
Thyroid gland 8 No (16/562) (5/8)
Trachea 8 No (3/562) (5/8)
Uterus 8 No (2/562) (2/8)
White adipose tissue 8 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (16)
  • Rpn2tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    LOWER URINARY TRACT, URINARY BLADDER, HET, Male, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    LUNG, HET, Male, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    TRACHEA, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    ESOPHAGUS, HET, Female, WTSI

show all 16 images

immune system (4)
  • Rpn2tm1a(EUCOMM)Wtsi
    PEYER'S PATCH, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    LYMPH NODE, INGUINAL LYMPH NODE, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    THYMUS, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    SPLEEN, HET, Female, WTSI
digestive system (3)
  • Rpn2tm1a(EUCOMM)Wtsi
    ESOPHAGUS, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    LARGE INTESTINE, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    PEYER'S PATCH, HET, Female, WTSI
nervous system (3)
  • Rpn2tm1a(EUCOMM)Wtsi
    PERIPHERAL NERVOUS SYSTEM, PITUITARY GLAND, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
urinary system (3)
  • Rpn2tm1a(EUCOMM)Wtsi
    LOWER URINARY TRACT, URINARY BLADDER, HET, Male, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    KIDNEY, HET, Female, WTSI
reproductive system (2)
  • Rpn2tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    UTERUS, OVIDUCT, OVARY, HET, Female, WTSI
respiratory system (2)
  • Rpn2tm1a(EUCOMM)Wtsi
    LUNG, HET, Male, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    TRACHEA, HET, Female, WTSI
cardiovascular system (1)
  • Rpn2tm1a(EUCOMM)Wtsi
    HEART, HET, Female, WTSI
endocrine system (1)
  • Rpn2tm1a(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Male, WTSI
integumental system (1)
  • Rpn2tm1a(EUCOMM)Wtsi
    SKIN, HET, Female, WTSI
sensory organ (1)
  • Rpn2tm1a(EUCOMM)Wtsi
    EYE, HET, Female, WTSI
set of connective tissues (1)
  • Rpn2tm1a(EUCOMM)Wtsi
    CARTILAGE TISSUE, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (129)
  • Rpn2tm1a(EUCOMM)Wtsi
    TRUNK, WT, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    TRUNK, WT, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    HEAD, WT, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    HEAD, WT, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    LOWER ARM, WT, Female, WTSI

show all 129 images

Skin Histopathology (3)
  • Rpn2tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
  • Rpn2tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI
Eye Morphology (1)
  • Rpn2tm1a(EUCOMM)Wtsi
    EYE, abnormal retinal pigmentation, HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Rpn2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene