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Gene: Maoa MGI:96915

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
monoamine oxidase A
Synonyms:
MAO-A,  1110061B18Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Maoa mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Maoa by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Brunner Syndrome
Kinetic tremor, Impulsivity, Aggressive behavior, Self-injurious behavior, Low frustration tolerance OMIM:300615
Monoamine Oxidase A Deficiency
ORPHA:3057

The table below shows human diseases predicted to be associated to Maoa by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Chromosome 15Q11-Q13 Duplication Syndrome
Restrictive behavior, Impaired ability to form peer relationships, Increased serum serotonin, Tru... OMIM:608636
Autism
Restrictive behavior, Impaired ability to form peer relationships, EEG abnormality, Increased ser... OMIM:209850
Autism, Susceptibility To, 8
Restrictive behavior, Impaired ability to form peer relationships, EEG abnormality, Increased ser... OMIM:607373
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder, Impaired social interactions, Compulsive behaviors OMIM:618830
Intellectual Developmental Disorder, Autosomal Recessive 66
Gait ataxia, Shyness, Attention deficit hyperactivity disorder, Aggressive behavior OMIM:618221
Charcot-Marie-Tooth syndrome type 1A (CMT1A)
Decreased motor nerve conduction velocity, Impaired vibratory sensation, Impaired temperature sen... DECIPHER:29
Dystonia 31
Generalized dystonia, Writer's cramp, Leg dystonia, Depression, Arm dystonia, Dysphagia, Abnormal... OMIM:619565
Autism, Susceptibility To, X-Linked 3
Restrictive behavior, EEG abnormality, Increased serum serotonin, Abnormal repetitive mannerisms,... OMIM:300496
Autism, Susceptibility To, X-Linked 1
Restrictive behavior, EEG abnormality, Increased serum serotonin, Abnormal repetitive mannerisms,... OMIM:300425
Intellectual Developmental Disorder, Autosomal Recessive 64
Impaired social interactions, Aggressive behavior OMIM:618103
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity, Abnormal social behavior ORPHA:436151
Asperger Syndrome, Susceptibility To, 1
Restrictive behavior, Abnormal repetitive mannerisms, Impaired ability to form peer relationships... OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Restrictive behavior, Abnormal repetitive mannerisms, Impaired ability to form peer relationships... OMIM:608631
Autosomal Recessive Cerebellar Ataxia-Movement Disorder Syndrome
Abnormal lower motor neuron morphology, Somatic sensory dysfunction, Impaired proprioception, Lim... ORPHA:95434
Pandas
Anorexia, Impulsivity, Abnormal fear-induced behavior, Chorea, Depression, Irritability, Tics, At... ORPHA:66624
Intellectual Developmental Disorder With Autism And Speech Delay
Abnormal repetitive mannerisms, Impaired social interactions OMIM:606053
Hereditary Geniospasm
Abnormal social behavior, Intention tremor ORPHA:53372
Neurodevelopmental Disorder With Hypotonia And Impaired Expressive Language And With Or Without Seizures
Aggressive behavior, EEG abnormality, Agitation, Emotional lability, Abnormal repetitive mannerisms OMIM:617171
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1
Aggressive behavior, Euphoria, EEG abnormality, Lateral ventricle dilatation, Inappropriate behav... OMIM:221770
Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures
Dystonia, Ataxia, Aggressive behavior, Chorea, Inappropriate laughter, Bruxism, Abnormal repetiti... OMIM:619150
Benign Paroxysmal Torticollis Of Infancy
Irritability, Torticollis, Ataxia, Abnormal head movements ORPHA:71518
Primary Lateral Sclerosis, Adult, 1
Abnormal upper motor neuron morphology, Dysphagia OMIM:611637
Huntington Disease-Like 1
Restlessness, Abnormal head movements, Chorea, Dysmetria, Depression, Gait ataxia, EEG abnormalit... ORPHA:157941
Pick Disease Of Brain
Abnormal repetitive mannerisms, Irritability, Disinhibition, Inappropriate laughter, Emotional bl... OMIM:172700
Autism, Susceptibility To, X-Linked 2
Restrictive behavior, EEG abnormality, Increased serum serotonin, Abnormal repetitive mannerisms,... OMIM:300495
Boucher-Neuhauser Syndrome
Hypogonadotropic hypogonadism, Ataxia, Gait ataxia, Decreased circulating gonadotropin concentrat... OMIM:215470
Primary Dystonia, Dyt13 Type
Torticollis, Generalized dystonia, Postural tremor, Dystonia, Torsion dystonia, Focal dystonia, L... ORPHA:98807
Hsd10 Disease
Ataxia, Tremor, Choreoathetosis, Dysphagia, Abnormal social behavior ORPHA:391417
Frontotemporal Dementia With Motor Neuron Disease
Abnormal lower motor neuron morphology, Depression, Progressive cerebellar ataxia, Disinhibition,... ORPHA:275872
Parkinsonism-Dystonia 3, Childhood-Onset
Dystonia, Ataxia, Aggressive behavior, Tremor, Chorea, Depression, Impaired social interactions, ... OMIM:619738
Juvenile Primary Lateral Sclerosis
Abnormal upper motor neuron morphology, Dysphagia ORPHA:247604
Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive
Self-injurious behavior, Abnormal repetitive mannerisms, Impaired social interactions, Dystonia OMIM:617820
Guanidinoacetate Methyltransferase Deficiency
Abnormal head movements, Hyperactivity, Ataxia, Aggressive behavior, Chorea, Self-injurious behav... ORPHA:382
Autosomal Dominant Spastic Ataxia Type 1
Spastic ataxia, Dystonia, Tremor, Impaired vibration sensation in the lower limbs, Impaired propr... ORPHA:251282
Gm2 Gangliosidosis, Ab Variant
Exaggerated startle response, Abnormal fear-induced behavior, Chorea, Inappropriate behavior, Dys... ORPHA:309246
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity, Impulsivity, Abnormal eating behavior, Aggressive behavior, Compulsive behaviors, ... ORPHA:101039
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Abnormal fear-induced behavior, Pseudobulbar paralysis, Aggressive behavior ORPHA:208441
Autism, Susceptibility To, 3
Restrictive behavior, Impaired ability to form peer relationships, EEG abnormality, Increased ser... OMIM:608049
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Hyperinsulinemia, Polyphagia, Impaired social interactions, Aggressive behavior ORPHA:329249
Severe Intellectual Disability-Progressive Postnatal Microcephaly-Midline Stereotypic Hand Movements Syndrome
Self-injurious behavior, Impaired social interactions, Stereotypical hand wringing ORPHA:397933
Hereditary Liability to Pressure Palsies (HNPP)
Abnormal motor neuron morphology, Motor conduction block DECIPHER:31
Primary Lateral Sclerosis, Juvenile
Abnormal upper motor neuron morphology, Pseudobulbar paralysis, Decreased compound muscle action ... OMIM:606353
Intellectual Developmental Disorder, Autosomal Recessive 6
Kinetic tremor, Torticollis, Postural tremor, Impaired social interactions OMIM:611092
Behavioral Variant Of Frontotemporal Dementia
Restrictive behavior, Collectionism, Restlessness, Aggressive behavior, Irritability, Inappropria... ORPHA:275864
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Frontotemporal Dementia
Amyotrophic lateral sclerosis, Irritability, Disinhibition, Inappropriate laughter, Polyphagia OMIM:600274
Dystonia 1, Torsion, Autosomal Dominant
Torticollis, Generalized dystonia, Writer's cramp, Tremor, Torsion dystonia, Depression, Blepharo... OMIM:128100
11Q22.2Q22.3 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Abnormal social behavior, Compulsive behaviors ORPHA:444002
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Resting tremor, Hyperactivity, Focal EEG discharges with secondary generalization, Anorexia, Aggr... ORPHA:3077
Foxg1 Syndrome
Dystonia, Choreoathetosis, Agenesis of corpus callosum, Impaired social interactions, Bruxism, Ab... ORPHA:561854
Lamb-Shaffer Syndrome
Hyperactivity, Ataxia, Abnormal temper tantrums, Abnormal social behavior, Abnormal repetitive ma... ORPHA:530983
Amyotrophic Lateral Sclerosis 2, Juvenile
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Generalized dystonia, Atax... OMIM:205100
Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia
Amyotrophic lateral sclerosis, Disinhibition, Dysphagia, Emotional lability, Abnormal repetitive ... OMIM:612069
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Resting tremor, Dystonia, Ataxia, Aggressive behavior, Tremor, Dysmetria, Depression, Gait ataxia... OMIM:615157
Syngap1-Related Developmental And Epileptic Encephalopathy
Ataxia, Abnormal eating behavior, Tremor, Impaired social interactions, Abnormality of pain sensa... ORPHA:544254
Primary Lateral Sclerosis
Abnormal lower motor neuron morphology, Somatic sensory dysfunction, Atrophy of the spinal cord, ... ORPHA:35689
Atypical Rett Syndrome
Restrictive behavior, Impaired pain sensation, Tremor, Tongue thrusting, Gait ataxia, Pill-rollin... ORPHA:3095
Spinal Muscular Atrophy, Segmental
Abnormal anterior horn cell morphology OMIM:183020
Brunner Syndrome
Kinetic tremor, Impulsivity, Aggressive behavior, Self-injurious behavior, Low frustration tolerance OMIM:300615
Congenital Arthrogryposis With Anterior Horn Cell Disease
Paucity of anterior horn motor neurons, Abnormal anterior horn cell morphology, Dystonia OMIM:611890
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Disinhibition, Dysphagia OMIM:616439
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Disinhibition, Dysphagia OMIM:616437
Neuronopathy, Distal Hereditary Motor, Autosomal Dominant 14
Abnormal lower motor neuron morphology OMIM:607641
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 6
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Dysphagia, Depression OMIM:613954
Mohr-Tranebjaerg Syndrome
Tremor, Abnormal posturing, Dystonia, Dysphagia OMIM:304700
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Hyperactivity, Diabetes mellitus, Hyperthyroidism, Aggressive behavior, Shyness, Hypothyroidism, ... ORPHA:449291
Jeavons Syndrome
Abnormal head movements, EEG with spike-wave complexes, EEG with generalized polyspikes, EEG with... ORPHA:139431
Amyotrophic Lateral Sclerosis 21
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Decreased nerve conduction... OMIM:606070
Spinal Muscular Atrophy-Progressive Myoclonic Epilepsy Syndrome
Abnormal lower motor neuron morphology, Tremor, Dysphagia ORPHA:2590
Childhood Absence Epilepsy
Depression, Punding, Attention deficit hyperactivity disorder, Abnormal social behavior, Jerky he... ORPHA:64280
Childhood Disintegrative Disorder
Abnormal repetitive mannerisms, Abnormal emotion, Impaired social interactions ORPHA:168782
Chorea, Childhood-Onset, With Psychomotor Retardation
Abnormal head movements, Chorea OMIM:616939
Spastic Paralysis, Infantile-Onset Ascending
Abnormal lower motor neuron morphology, Dysphagia OMIM:607225
X-Linked Intellectual Disability, Van Esch Type
Hypergonadotropic hypogonadism, Increased circulating gonadotropin level, Absence of secondary se... ORPHA:163976
Myoclonic-Astatic Epilepsy
EEG with polyspike wave complexes, Hyperactivity, EEG with focal spike waves, Ataxia, Tremor, EEG... ORPHA:1942
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Depression OMIM:105550
Neurodegeneration With Brain Iron Accumulation 4
Abnormal lower motor neuron morphology, Generalized dystonia, Ataxia, Impulsivity, Tremor, Depres... OMIM:614298
Choreoacanthocytosis
Chorea, Compulsive behaviors, Limb dystonia, Laryngeal dystonia, Impaired vibratory sensation, Se... ORPHA:2388
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy, Ataxia, Type II diabetes mellitus, Depression OMIM:604121
Early-Onset Autosomal Dominant Alzheimer Disease
Abnormal social behavior, Agitation, Ataxia, Disinhibition ORPHA:1020
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia
Athetosis, Amyotrophic lateral sclerosis, Dystonia, Dysphagia OMIM:300857
Amyotrophic Lateral Sclerosis 11
Decreased nerve conduction velocity, Amyotrophic lateral sclerosis, Somatic sensory dysfunction OMIM:612577
Sporadic Infantile Bilateral Striatal Necrosis
Resting tremor, Dystonia, Chorea, Gait ataxia, Titubation, Dysphagia, Abnormal posturing ORPHA:225147
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Ataxia, Aggressive behavior, Attention deficit hyperactivity disorder, Impaired so... OMIM:610042
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 4
Abnormal lower motor neuron morphology OMIM:611067
Progressive Supranuclear Palsy-Corticobasal Syndrome
Somatic sensory dysfunction, Tremor, Focal dystonia, Dysphagia, Jerky head movements ORPHA:240103
Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures
Ataxia, Impulsivity, Aggressive behavior, Tongue thrusting, Gait ataxia, Choreoathetosis, Opistho... OMIM:619580
Niemann-Pick Disease Type C
Limb dystonia, Axial dystonia, Dystonia, Ataxia, Aggressive behavior, Tremor, Narcolepsy, Chorea,... ORPHA:646
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Decreased response to growth hormone stimulation test, Central diabetes insipidus, Aggressive beh... ORPHA:293987
Japanese Encephalitis
Decreased motor nerve conduction velocity, Hyperintensity of MRI T2 signal of the spinal cord, Dy... ORPHA:79139
Metachromatic Leukodystrophy, Late Infantile Form
Gait ataxia, Progressive gait ataxia, Dystonia, Emotional lability, Abnormal social behavior ORPHA:309256
48,Xxxy Syndrome
Tremor, Irritability, Hypogonadism, Type II diabetes mellitus, Attention deficit hyperactivity di... ORPHA:96263
Polyglucosan Body Neuropathy, Adult Form
Abnormal upper motor neuron morphology, Paresthesia, Distal sensory impairment OMIM:263570
Rett Syndrome, Congenital Variant
Dystonia, Chorea, Tongue thrusting, Irritability, Athetosis, Impaired social interactions, Bruxis... OMIM:613454
Autosomal Recessive Ataxia Due To Pex10 Deficiency
Abnormal head movements, Limb ataxia, Progressive cerebellar ataxia, Progressive gait ataxia, Typ... ORPHA:247815
Classic Pantothenate Kinase-Associated Neurodegeneration
Generalized dystonia, Opisthotonus, Attention deficit hyperactivity disorder, Dysphagia, Abnormal... ORPHA:216866
Metachromatic Leukodystrophy, Juvenile Form
Progressive gait ataxia, Dystonia, Emotional lability, Abnormal social behavior, Intention tremor ORPHA:309263
Machado-Joseph Disease Type 3
Abnormal lower motor neuron morphology, Dystonia, Degeneration of anterior horn cells, Progressiv... ORPHA:276244
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia
Amyotrophic lateral sclerosis, Abnormal motor neuron morphology ORPHA:52430
Amyotrophic Lateral Sclerosis 23
Degeneration of anterior horn cells, Amyotrophic lateral sclerosis, Dysphagia OMIM:617839
Metachromatic Leukodystrophy, Adult Form
Chorea, Depression, Progressive gait ataxia, Dystonia, Emotional lability, Abnormal social behavi... ORPHA:309271
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Motor neuron atrophy, Inappropriate behavior, Spinocerebellar tract degeneration, Abnormal neuron... ORPHA:412066
Episodic Ataxia Type 4
Abnormal head movements, Ataxia ORPHA:79136
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis OMIM:105500
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Extraadrenal pheochromocytoma, Paraganglioma of head and neck, Glomus tympan... OMIM:168000
Pyruvate Dehydrogenase E2 Deficiency
Paroxysmal dystonia, Generalized dystonia, Ataxia, Choreoathetosis, Dystonia, Jerky head movements OMIM:245348
Amyotrophic Lateral Sclerosis 1
Degeneration of anterior horn cells, Amyotrophic lateral sclerosis, Pseudobulbar paralysis, Dysph... OMIM:105400
Amyotrophic Lateral Sclerosis 4, Juvenile
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Pallor of dorsal columns o... OMIM:602433
Progressive Non-Fluent Aphasia
Abnormal lower motor neuron morphology, Restlessness, EEG with continuous slow activity, Depression ORPHA:100070
Intellectual Developmental Disorder, X-Linked 98
Hyperactivity, Ataxia, Aggressive behavior, Bulimia, Self-biting, Central hypothyroidism, Stereot... OMIM:300912
Pheochromocytoma/Paraganglioma Syndrome 3
Extraadrenal pheochromocytoma, Chemodectoma, Adrenal pheochromocytoma, Glomus jugular tumor, Para... OMIM:605373
Juvenile Amyotrophic Lateral Sclerosis
Axial dystonia, Amyotrophic lateral sclerosis, Dystonia, Ataxia, Head titubation, Chorea, Opistho... ORPHA:300605
Amyotrophic Lateral Sclerosis 5, Juvenile
Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis OMIM:602099
Wagro Syndrome
Aggressive behavior, Agitation, Low frustration tolerance, Compulsive behaviors, Impaired social ... OMIM:612469
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Resting tremor, Ataxia, Narcolepsy, Depression, Head tremor ORPHA:314404
New-Onset Refractory Status Epilepticus
Interictal EEG abnormality, Abnormal head movements, Multifocal epileptiform discharges, EEG with... ORPHA:363558
Spastic Paraplegia 9A, Autosomal Dominant
Impaired vibratory sensation, Resting tremor, Abnormal upper motor neuron morphology, Gait ataxia OMIM:601162
Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis, Motor neuron atrophy, Depression, Agitation, Emotional lability ORPHA:803
Fragile X Syndrome
Abnormal head movements, Hyperactivity, Recurrent hand flapping, Self-biting OMIM:300624
Young-Onset Parkinson Disease
Restless legs, Impulsivity, Tremor, Depression, Agitation, Impaired social interactions, Dystonia ORPHA:2828
Intellectual Developmental Disorder, Autosomal Dominant 38
Ataxia, Aggressive behavior, Hair-pulling, Self-injurious behavior, Bruxism, Abnormal repetitive ... OMIM:616393
Ane Syndrome
Decreased serum insulin-like growth factor 1, Hypogonadotropic hypogonadism, Anterior pituitary h... ORPHA:157954
Amyotrophic Lateral Sclerosis, Susceptibility To, 24
Amyotrophic lateral sclerosis, Dysphagia OMIM:617892
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
47,Xyy Syndrome
Hyperactivity, Impulsivity, Increased circulating gonadotropin level, Attention deficit hyperacti... ORPHA:8
Amyotrophic Lateral Sclerosis 18
Amyotrophic lateral sclerosis, Dysphagia OMIM:614808
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 2
Amyotrophic lateral sclerosis, Ataxia, Dysphagia OMIM:615911
African Trypanosomiasis
Somatic sensory dysfunction, Aggressive behavior, Abnormality of the endocrine system, Myelopathy... ORPHA:3385
Huntington Disease-Like 3
Abnormal head movements, Chorea, Dystonia, Progressive gait ataxia ORPHA:157946
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Ataxia, Aggressive behavior, Dysmetria, Positive Romberg sign, Nonprogressive cerebellar ataxia, ... ORPHA:314647
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hyperactivity, Hair-pulling, Hypsarrhythmia, Irritability, Dysphagia, Abnormal repetitive mannerisms ORPHA:447997
Amyotrophic Lateral Sclerosis 12 With Or Without Frontotemporal Dementia
Amyotrophic lateral sclerosis, Dysphagia OMIM:613435
Prader-Willi Syndrome Due To Translocation
Hypogonadotropic hypogonadism, Decreased response to growth hormone stimulation test, Anterior pi... ORPHA:177907
Infantile-Onset X-Linked Spinal Muscular Atrophy
Degeneration of anterior horn cells, Abnormal anterior horn cell morphology ORPHA:1145
Porphyria Due To Ala Dehydratase Deficiency
Abnormal fear-induced behavior, Agitation, Restlessness, Depression ORPHA:100924
Amyotrophic Lateral Sclerosis 8
Amyotrophic lateral sclerosis, Postural tremor, Dysphagia OMIM:608627
Tuberous Sclerosis Complex
Hyperactivity, Impulsivity, Aggressive behavior, Pancreatic endocrine tumor, Pituitary adenoma, R... ORPHA:805
Fg Syndrome Type 1
Attention deficit hyperactivity disorder, Abnormal social behavior, Small pituitary gland, Compul... ORPHA:93932
Methylmalonic Aciduria And Homocystinuria, Cblj Type
Abnormal posturing OMIM:614857
Sandifer Syndrome
Abnormal head movements, Torticollis, Abnormal posturing ORPHA:71272
Vocal Cord And Pharyngeal Distal Myopathy
Decreased nerve conduction velocity, Amyotrophic lateral sclerosis, Distal sensory impairment, Dy... ORPHA:600
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Nail-biting, Pain insensitivity, Aggressive behavior, Hair-pulling, Polyphagia, Self-injurious be... OMIM:620330
Narcolepsy 7
Narcolepsy, Type II diabetes mellitus OMIM:614250
Trichotillomania
Hair-pulling, Compulsive behaviors OMIM:613229
Lethal Congenital Contracture Syndrome 1
Paucity of anterior horn motor neurons OMIM:253310
Dihydropyrimidine Dehydrogenase Deficiency
Irritability, Abnormal social behavior, Abnormal aggressive, impulsive or violent behavior ORPHA:1675
Vici Syndrome
Abnormal posturing, Abnormal thymus morphology, Agenesis of corpus callosum, Dysphagia OMIM:242840
1P21.3 Microdeletion Syndrome
Abnormal eating behavior, Shyness, Aggressive behavior, Self-injurious behavior, Self-mutilation ORPHA:293948
Koolen-De Vries Syndrome Due To A Point Mutation
Decreased response to growth hormone stimulation test, Spina bifida, Precocious puberty, Primary ... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Decreased response to growth hormone stimulation test, Spina bifida, Precocious puberty, Primary ... ORPHA:363958
Ocular Motor Apraxia
Jerky head movements OMIM:257550
Laryngotracheoesophageal Cleft Type 4
Abnormal lower motor neuron morphology ORPHA:93941
Monosomy 22Q13.3
Hyperactivity, Impaired pain sensation, Hair-pulling, Bruxism, Agenesis of corpus callosum ORPHA:48652
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Cervical cord co... ORPHA:353281
Mend Syndrome
Hyperactivity, Abnormal social behavior, Aggressive behavior ORPHA:401973
Ogden Syndrome
Abnormal head movements, Torticollis ORPHA:276432
Unilateral Polymicrogyria
Pseudobulbar paralysis, Giant somatosensory evoked potentials, Abnormal posturing ORPHA:268943
Trichothiodystrophy
Reduced social reciprocity, Partial agenesis of the corpus callosum, Intention tremor, Gait ataxia ORPHA:33364
Narcolepsy 3
Narcolepsy OMIM:609039
Narcolepsy 1
Narcolepsy OMIM:161400
Von Hippel-Lindau Disease
Pancreatic islet cell adenoma, Pancreatic endocrine tumor, Adrenal pheochromocytoma, Paragangliom... ORPHA:892
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Hyperactivity, Abnormal lateral ventricle morphology, Impulsivity, Aggressive behavior, Abnormal ... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Hyperactivity, Abnormal lateral ventricle morphology, Impulsivity, Aggressive behavior, Abnormal ... ORPHA:353277
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome
Hypoparathyroidism, Precocious puberty, Multifocal epileptiform discharges, EEG with generalized ... ORPHA:369837
Williams Syndrome
Hypogonadotropic hypogonadism, Ataxia, Precocious puberty, Tremor, Dysmetria, Depression, Type II... ORPHA:904
Idiopathic Camptocormia
Amyotrophic lateral sclerosis, Syringomyelia, Myelitis, Dystonia ORPHA:1320
Monoamine Oxidase A Deficiency
ORPHA:3057

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Maoa

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Maoa.

No publications found that use IMPC mice or data for Maoa.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Maoatm41064(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Maoatm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Maoatm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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