Gene: Lmnb2

Order

Name lamin B2

Synonyms lamin B3

Status ES CellsMice
tm1a
phenotype data available

Links MGI:96796    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Lmnb2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Lmnb2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Lmnb2tm1a(KOMP)Wtsi HOM Female Male n/a 0.0
increased circulating creatinine level Lmnb2tm1a(KOMP)Wtsi HET Male postnatal 4.18E-13
decreased body weight Lmnb2tm1a(KOMP)Wtsi HET Female postnatal 1.46E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/2)
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No
Gall bladder 2 No
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (1/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No (1/2)
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system digestive system cardiovascular system nervous system set of connective tissues reproductive system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (17)
  • Lmnb2tm1a(KOMP)Wtsi
    ovary, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    thymus, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI

show all 17 images

trunk (12)
  • Lmnb2tm1a(KOMP)Wtsi
    ovary, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    thymus, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI

show all 12 images

nervous system (5)
  • Lmnb2tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    peripheral nervous system, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    pituitary gland, HET, Male, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    spinal cord, HET, Male, WTSI
digestive system (4)
  • Lmnb2tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    stomach, HET, Male, WTSI
reproductive system (2)
  • Lmnb2tm1a(KOMP)Wtsi
    ovary, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
urinary system (2)
  • Lmnb2tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
cardiovascular system (1)
  • Lmnb2tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
immune system (1)
  • Lmnb2tm1a(KOMP)Wtsi
    thymus, HET, Female, WTSI
respiratory system (1)
  • Lmnb2tm1a(KOMP)Wtsi
    trachea, HET, Male, WTSI
set of connective tissues (1)
  • Lmnb2tm1a(KOMP)Wtsi
    cartilage tissue, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (109)
  • Lmnb2tm1a(KOMP)Wtsi
    forearm, WT, Male, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    body, WT, Male, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    forearm, WT, Male, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    body, WT, Male, WTSI
  • Lmnb2tm1a(KOMP)Wtsi
    head, WT, Male, WTSI

show all 109 images

Eye Morphology (1)
  • Lmnb2tm1a(KOMP)Wtsi
    eye, abnormal pupil morphology, abnormal placement of pupils, HET, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Lmnb2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Lmnb2tm82511(L1L2_gt0)
Vector
Gene
Lmnb2tm82511(pL1L2_GT0_bsd_frt15_neo_barcode)
Vector
Gene