Gene: Htr1b

Order

Name 5-hydroxytryptamine (serotonin) receptor 1B

Synonyms
  • 5HT1B receptor
  • 5-HT<1B> receptor
  • 5-HT1B receptor

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:96274    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Htr1b

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Htr1b data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Htr1btm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
decreased anxiety-related response Htr1btm1.1(KOMP)Vlcg HET Female Male postnatal 2.09E-11
increased lean body mass Htr1btm1.1(KOMP)Vlcg HET Female Male postnatal 2.97E-8
abnormal behavioral response to light Htr1btm1.1(KOMP)Vlcg HET Female Male postnatal 5.09E-7
thrombocytopenia Htr1btm1.1(KOMP)Vlcg HET Female Male postnatal 8.0E-6
decreased total body fat amount Htr1btm1.1(KOMP)Vlcg HET Male postnatal 2.48E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Epididymis 2 No (18/134)
Esophagus 2 No (7/415)
Eye 2 No (2/2)
Heart 2 No
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No (1/2)
Mammary gland 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No
Pancreas 2 No (5/584) (1/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (1/2)
Striatum 2 No (2/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (1/2)
Trachea 2 No (1/2)
Urinary bladder 2 No
Uterus 2 No
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse respiratory system digestive system cardiovascular system nervous system sensory organ reproductive system immune system exocrine system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (2/3)
Dorsal root ganglion 1 (1/47)
Ear 2 (1/485)
Embryo 2 (1/485) (2/3)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485)
Fronto-nasal process 1 (1/48) Image Only
Hand 2 (1/485)
Head 2 (5/485) (2/3)
Heart 2 (1/485)
Hindbrain 2 (6/485) (2/3)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485) (1/3)
Maxillary process 2 (1/485) (2/3)
Midbrain 2 (1/485)
Nose 1 (1/51)
Oral cavity 2 (1/485) Image Only
Skin 2 (1/485) (1/3)
Spinal cord 1 (1/50) (1/1)
Tail 2 (1/485)
Tail somite 2 (1/485)
Thoracic vertebral cartilage condensation 1 (1/46) (1/1)


Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • Sleep Wake: Wake state (bmp file)
    7 Images
  • Electroretinography: Rod waveform (pdf format)
    4 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • Electroretinography: Cone waveform (pdf format)
    4 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Combined SHIRPA and Dysmorphology
    3 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Htr1btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Htr1btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene