Gene: Hspa5

Order

Name heat shock protein 5

Synonyms
  • mBiP
  • D2Wsu17e
  • baffled
  • D2Wsu141e
  • Grp78
  • XAP-1 antigen
  • Bip
  • Hsce70
  • Sez7
  • 78kDa

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:95835    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Hspa5

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Hspa5 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Hspa5tm1.1(KOMP)Vlcg HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Hspa5tm1.1(KOMP)Vlcg HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Hspa5tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
decreased circulating insulin level Hspa5tm1.1(KOMP)Vlcg HET Female Male postnatal 1.41E-15
decreased circulating HDL cholesterol level Hspa5tm1.1(KOMP)Vlcg HET Male postnatal 1.16E-6
increased circulating HDL cholesterol level Hspa5tm1.1(KOMP)Vlcg HET Female postnatal 1.16E-6
decreased lean body mass Hspa5tm1.1(KOMP)Vlcg HET Female postnatal 1.27E-5
increased lean body mass Hspa5tm1.1(KOMP)Vlcg HET Male postnatal 1.27E-5
decreased total body fat amount Hspa5tm1.1(KOMP)Vlcg HET Male postnatal 3.88E-5
increased total body fat amount Hspa5tm1.1(KOMP)Vlcg HET Female postnatal 3.88E-5
increased circulating cholesterol level Hspa5tm1.1(KOMP)Vlcg HET Female postnatal 4.63E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (1/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415)
Eye 2 No (1/2)
Heart 2 No (2/2)
Hippocampus 2 No (1/2)
Hypothalamus 2 No (1/2)
Kidney 2 No (18/584) (1/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (1/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (1/2)
Striatum 2 No
Submandibular gland 2 No (2/132) (1/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (1/2)
Urinary bladder 2 No (1/2)
Uterus 2 No (1/2)
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system respiratory system digestive system cardiovascular system nervous system sensory organ reproductive system immune system exocrine system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (2/2)
Dorsal root ganglion 1 (1/47) Image Only
Ear 2 (1/485)
Embryo 2 (1/485) (2/2)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485) Image Only
Forelimb 2 (1/485) (2/2)
Fronto-nasal process 1 (1/48) Image Only
Hand 2 (1/485) (1/2)
Head 2 (5/485) (2/2)
Heart 2 (1/485) (2/2)
Hindbrain 2 (6/485) (2/2)
Hindlimb 2 (1/485) (1/2)
Liver 2 (1/485) (2/2)
Lung 2 (1/485) Image Only
Mandibular process 2 (1/485) (2/2)
Maxillary process 2 (1/485) (1/2)
Midbrain 2 (1/485) (1/2)
Nose 1 (1/51) Image Only
Oral cavity 2 (1/485) Image Only
Skin 2 (1/485) Image Only
Spinal cord 1 (1/50) (1/1)
Tail 2 (1/485) (1/2)
Tail somite 2 (1/485) Image Only


Associated Images

Associated Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    13 Images
  • X-ray: XRay Images Lateral Orientation
    13 Images
  • X-ray: XRay Images Forepaw
    13 Images
  • X-ray: XRay Images Skull Lateral Orientation
    13 Images
  • Combined SHIRPA and Dysmorphology
    3 Images
  • Electroretinography: Rod waveform (pdf format)
    2 Images
  • X-ray: XRay Images Dorso Ventral
    13 Images
  • Electroretinography: Cone waveform (pdf format)
    2 Images
  • Sleep Wake: Wake state (bmp file)
    8 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Hspa5tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Hspa5tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene