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Gene: Grin1

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Name glutamate receptor, ionotropic, NMDA1 (zeta 1)

Synonyms
  • NMDAR1
  • NR1
  • Rgsc174
  • GluRzeta1
  • Nmdar
  • M100174

Status ES CellsMice
tm1aphenotype data available

Links MGI:95819   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Grin1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Grin1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Grin1tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
increased hemoglobin content Grin1tm1a(EUCOMM)Wtsi HET Female Male postnatal 5.21E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse nervous system
No expression image was found for this adult tab
No expression data was found for this embryo tab

Secondary lacZ Expression Data
nervous system (2)
  • Grin1tm1a(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
  • Grin1tm1a(EUCOMM)Wtsi
    BRAIN, HET, Female, WTSI
reproductive system (1)
  • Grin1tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
trunk (1)
  • Grin1tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (105)
  • Grin1tm1a(EUCOMM)Wtsi
    HEAD, HET, Male, WTSI
  • Grin1tm1a(EUCOMM)Wtsi
    HEAD, HET, Male, WTSI
  • Grin1tm1a(EUCOMM)Wtsi
    HEAD, HET, Male, WTSI
  • Grin1tm1a(EUCOMM)Wtsi
    LOWER ARM, HET, Male, WTSI
  • Grin1tm1a(EUCOMM)Wtsi
    TRUNK, HET, Male, WTSI

show all 105 images

Eye Morphology (3)
  • Grin1tm1a(EUCOMM)Wtsi
    EYE, abnormal retinal pigmentation, HET, Male, WTSI
  • Grin1tm1a(EUCOMM)Wtsi
    EYE, abnormal pupil morphology, abnormal placement of pupils, HET, Male, WTSI
  • Grin1tm1a(EUCOMM)Wtsi
    EYE, fused cornea and lens, corneal vascularization, corneal opacity, HET, Female, WTSI
Skin Histopathology (1)
  • Grin1tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HET, Female, WTSI

Disease Models

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Grin1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Grin1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Grin1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene