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Gene: Lrrc32 MGI:93882

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
leucine rich repeat containing 32
Synonyms:
Garp,  D11S833Eh,  EG434215,  D7H11S833E

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lrrc32 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Lrrc32 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cleft Palate, Proliferative Retinopathy, And Developmental Delay
Cleft palate, Short philtrum OMIM:619074

The table below shows human diseases predicted to be associated to Lrrc32 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Syngnathia
Cleft palate OMIM:119550
Orofacial Cleft 11
Cleft lip, Cleft palate OMIM:600625
Orofacial Cleft 10
Unilateral cleft lip, Unilateral cleft palate OMIM:613705
Palatopharyngeal Incompetence
Velopharyngeal insufficiency, Cleft palate OMIM:167500
Ankyloblepharon Filiforme Adnatum-Imperforate Anus Syndrome
Non-midline cleft of the upper lip, Cleft palate, Tooth agenesis ORPHA:1074
Orofacial Cleft 6, Susceptibility To
Cleft upper lip, Cleft palate OMIM:608864
Orofacial Cleft 1
Cleft upper lip, Cleft palate OMIM:119530
Orofacial Cleft 5
Cleft upper lip, Cleft palate OMIM:608874
Congenital Laryngomalacia
Non-midline cleft of the upper lip, Cleft palate ORPHA:2373
Ankyloblepharon Filiforme Adnatum And Cleft Palate
Cleft upper lip, Cleft palate OMIM:106250
Pierre Robin Syndrome
Pierre-Robin sequence, Glossoptosis, Cleft palate OMIM:261800
Pierre Robin Syndrome And Oligodactyly
Pierre-Robin sequence, Cleft palate OMIM:172880
Isolated Pierre Robin Syndrome
Cleft palate, Glossoptosis ORPHA:718
Megaepiphyseal Dwarfism
Cleft palate OMIM:249230
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Cleft Palate, Isolated
Anterior open-bite malocclusion, Gingival overgrowth, Cleft palate, Increased overbite OMIM:119540
Cleft Palate-Lateral Synechia Syndrome
Cleft palate, Narrow mouth, Everted lower lip vermilion, Oral synechia ORPHA:2016
2q33.1 deletion syndrome
Cleft palate, High palate DECIPHER:51
Omphalocele-Cleft Palate Syndrome, Lethal
Bifid uvula, Cleft palate, Death in infancy OMIM:258320
Pierre Robin Sequence With Facial And Digital Anomalies
Pierre-Robin sequence, Glossoptosis, Cleft palate OMIM:311895
Van Der Woude Syndrome 1
Cleft upper lip, Bifid uvula, Cleft palate, Hypodontia, Lower lip pit OMIM:119300
Sprengel Deformity
Cleft palate ORPHA:3181
16P11.2P12.2 Microduplication Syndrome
Attention deficit hyperactivity disorder, Cleft palate ORPHA:261204
Parc Syndrome
Cleft palate OMIM:600331
Weaver-Williams Syndrome
Cleft palate, Narrow mouth ORPHA:3448
Adducted Thumbs Syndrome
High, narrow palate, High palate, Velopharyngeal insufficiency, Cleft palate, Dysphagia OMIM:201550
Diffuse Gastric And Lobular Breast Cancer Syndrome
Cleft upper lip, Cleft palate, Atrophic gastritis, Stomach cancer OMIM:137215
Cleft Lip/Palate
Orofacial cleft, Abnormal number of permanent teeth, Oral-pharyngeal dysphagia, Palate fistula, B... ORPHA:199306
Facial Clefting, Oblique, 1
Cleft upper lip, Tessier number 4 facial cleft, Cleft palate OMIM:600251
Cleft Palate With Or Without Ankyloglossia, X-Linked
Bifid uvula, Cleft palate, Ankyloglossia OMIM:303400
Intellectual Developmental Disorder With Autism And Dysmorphic Facies
High palate, Compulsive behaviors, Recurrent hand flapping, Cleft palate, Open mouth, Attention d... OMIM:620021
Holzgreve Syndrome
Cleft upper lip, Cleft palate OMIM:236110
Van Der Woude Syndrome 2
Cleft upper lip, Cleft palate, Anodontia, Hypodontia, Dental malocclusion, Lip pit OMIM:606713
Trochlea Of The Humerus, Aplasia Of
Cleft palate OMIM:191000
Robin Sequence-Oligodactyly Syndrome
Cleft palate, Glossoptosis, Abnormality of the dentition ORPHA:3104
Splenogonadal Fusion With Limb Defects And Micrognathia
Stillbirth, Crowded maxillary incisors, Multiple unerupted teeth OMIM:183300
Van Der Woude Syndrome
Abnormal salivary gland morphology, Cleft upper lip, Cleft palate, Hypodontia, Lower lip pit, Lip... ORPHA:888
Auriculocondylar Syndrome 4
Narrow mouth, Cleft palate, Glossoptosis OMIM:620457
Catifa Syndrome
Delayed eruption of teeth, Tooth malposition, Increased overbite, Attention deficit hyperactivity... OMIM:618761
Radius, Aplasia Of, With Cleft Lip/Palate
Cleft upper lip, Cleft palate OMIM:179400
Contractures, Congenital, Torticollis, And Malignant Hyperthermia
Cleft palate, Natal tooth OMIM:217150
Ankyloblepharon Filiforme Adnatum-Cleft Palate Syndrome
Non-midline cleft of the upper lip, Cleft palate, Lip pit ORPHA:1072
Anencephaly 2
Cleft maxillary alveolar ridge, Median cleft palate, Median cleft upper lip OMIM:619452
Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Impaired Intellectual Development
Cleft upper lip, Cleft palate OMIM:120433
Contractures-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome
Non-midline cleft of the upper lip, Cleft palate ORPHA:1484
Chromosome 15Q14 Deletion Syndrome
Short philtrum, Everted lower lip vermilion, Cleft palate, Tented upper lip vermilion, Cleft lip OMIM:616898
Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Cleft lip, Cleft palate OMIM:612370
Bamforth-Lazarus Syndrome
Cleft palate OMIM:241850
Microphthalmia, Syndromic 8
Orofacial cleft, Widely-spaced maxillary central incisors, Cleft palate, Cleft upper lip OMIM:601349
Diprosopus
Non-midline cleft of the upper lip, Cleft palate ORPHA:1681
Microcephaly-Cleft Palate-Abnormal Retinal Pigmentation Syndrome
Submucous cleft hard palate, Bifid uvula, Cleft palate ORPHA:2521
Hemifacial Microsomia With Radial Defects
Short mandibular rami, Orofacial cleft, Cleft palate, Non-midline cleft of the upper lip OMIM:141400
Hamel Cerebro-Palato-Cardiac Syndrome
Cleft palate, Narrow mouth, Death in infancy ORPHA:93946
Microphthalmia, Syndromic 11
Cleft upper lip, Cleft palate OMIM:614402
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Non-midline cleft of the upper lip, Ectopic anus, Cleft palate ORPHA:2476
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia
Esophageal stenosis, Neonatal death, Oral mucosal blisters, Congenital pyloric atresia OMIM:619817
Dystonia-Deafness Syndrome 1
Cleft upper lip, Cleft palate, Dysphagia, Pseudobulbar paralysis OMIM:607371
Cleft Soft Palate
Cleft soft palate OMIM:119570
Microtia, Hearing Impairment, And Cleft Palate
Cleft palate OMIM:612290
Aase-Smith Syndrome I
Cleft palate, Open mouth, Death in infancy OMIM:147800
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uvula, Unilateral cleft lip, Cleft palate, Cleft soft palate ORPHA:2736
Lymphatic Malformation 5
Cleft palate OMIM:153200
Isotretinoin Embryopathy-Like Syndrome
Cleft palate OMIM:243440
Cleft Palate, Proliferative Retinopathy, And Developmental Delay
Cleft palate, Short philtrum OMIM:619074
Sacral Agenesis With Vertebral Anomalies
Neonatal death, Anal atresia, Persistent cloaca OMIM:615709

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrrc32

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrrc32.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Cell (June 2018) Lrrc32tm1(KOMP)Vlcg 29909984

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MGI Allele Allele Type Produced
Lrrc32tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Lrrc32tm406003(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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