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Gene: F13b MGI:88379

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
coagulation factor XIII, beta subunit
Synonyms:
Cf-13b,  Cf13b

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by F13b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to F13b by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Factor Xiii, B Subunit, Deficiency Of
Abnormal bleeding, Abnormal umbilical stump bleeding, Ecchymosis, Bruising susceptibility, Prolon... OMIM:613235
Congenital Factor Xiii Deficiency
Spontaneous hematomas, Post-partum hemorrhage, Oral cavity bleeding, Gingival bleeding, Delayed o... ORPHA:331

The table below shows human diseases predicted to be associated to F13b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Von Willebrand Disease, X-Linked Form
Prolonged bleeding time, Abnormal bleeding OMIM:314560
Tatsumi Factor Deficiency
Prolonged bleeding time, Abnormal bleeding OMIM:272650
Athrombia, Essential
Impaired platelet aggregation, Prolonged bleeding time, Abnormal bleeding, Impaired platelet adhe... OMIM:209050
Von Willebrand Disease, Platelet-Type
Prolonged bleeding time OMIM:177820
Glanzmann Thrombasthenia 2
Abnormal bleeding, Impaired epinephrine-induced platelet aggregation, Impaired clot retraction, D... OMIM:619267
Bleeding Disorder, Platelet-Type, 18
Impaired epinephrine-induced platelet aggregation, Impaired ADP-induced platelet aggregation, Men... OMIM:615888
Bleeding Disorder, Platelet-Type, 11
Impaired collagen-induced platelet aggregation, Menorrhagia, Ecchymosis, Epistaxis, Bruising susc... OMIM:614201
Platelet Glycoprotein Iv Deficiency
Prolonged bleeding time, Abnormal bleeding OMIM:608404
Glanzmann Thrombasthenia 1
Gastrointestinal hemorrhage, Purpura, Impaired epinephrine-induced platelet aggregation, Excessiv... OMIM:273800
Glanzmann Thrombasthenia
Spontaneous hematomas, Gastrointestinal hemorrhage, Purpura, Spontaneous, recurrent epistaxis, Gi... ORPHA:849
Factor V Deficiency
Prolonged prothrombin time, Abnormal bleeding, Menorrhagia, Epistaxis, Bruising susceptibility, P... OMIM:227400
Bernard-Soulier Syndrome
Purpura, Abnormal bleeding, Gastrointestinal hemorrhage, Gingival bleeding, Menorrhagia, Epistaxi... OMIM:231200
Prothrombin Deficiency, Congenital
Prolonged prothrombin time, Gastrointestinal hemorrhage, Gingival bleeding, Menorrhagia, Joint he... OMIM:613679
Platelet Disorder, Undefined
Impaired platelet aggregation, Prolonged bleeding time, Abnormal bleeding OMIM:173420
Von Willebrand Disease, Type 3
Abnormal bleeding, Impaired platelet aggregation, Prolonged bleeding time, Menorrhagia, Joint hem... OMIM:277480
Hermansky-Pudlak Syndrome 7
Impaired platelet aggregation, Post-partum hemorrhage, Menorrhagia, Epistaxis, Persistent bleedin... OMIM:614076
Macrothrombocytopenia And Granulocyte Inclusions With Or Without Nephritis Or Sensorineural Hearing Loss
Abnormal bleeding, Impaired epinephrine-induced platelet aggregation, Impaired ADP-induced platel... OMIM:155100
Hemophilia B
Cephalohematoma, Spontaneous, recurrent epistaxis, Delayed onset bleeding, Joint hemorrhage, Intr... ORPHA:98879
Von Willebrand Disease, Type 1
Gastrointestinal hemorrhage, Impaired platelet aggregation, Menorrhagia, Joint hemorrhage, Epista... OMIM:193400
Storage Pool Platelet Disease
Prolonged bleeding time, Abnormal bleeding OMIM:185050
Gray Platelet Syndrome
Abnormal bleeding, Impaired thrombin-induced platelet aggregation, Impaired collagen-induced plat... OMIM:139090
Bleeding Disorder, Platelet-Type, 17
Abnormal bleeding, Gastrointestinal hemorrhage, Impaired epinephrine-induced platelet aggregation... OMIM:187900
Thrombocytopenia, Paris-Trousseau Type
Prolonged bleeding time, Abnormal bleeding OMIM:188025
Congenital Factor Ii Deficiency
Prolonged prothrombin time, Abnormal bleeding, Cephalohematoma, Excessive bleeding from superfici... ORPHA:325
Thrombocytopenia With Beta-Thalassemia, X-Linked
Petechiae, Bruising susceptibility, Epistaxis, Prolonged bleeding time OMIM:314050
Slc35A1-Cdg
Subcutaneous hemorrhage, Prolonged bleeding time, Abnormal bleeding, Pulmonary hemorrhage ORPHA:238459
Congenital Factor Vii Deficiency
Prolonged prothrombin time, Gastrointestinal hemorrhage, Post-partum hemorrhage, Gingival bleedin... ORPHA:327
Aplasia Cutis Congenita
Prolonged bleeding time ORPHA:1114
Factor X Deficiency
Prolonged prothrombin time, Gingival bleeding, Menorrhagia, Joint hemorrhage, Epistaxis, Intracra... OMIM:227600
Blue Rubber Bleb Nevus
Prolonged bleeding time, Intestinal bleeding ORPHA:1059
Platelet Disorder, Familial, With Associated Myeloid Malignancy
Purpura, Impaired platelet aggregation, Petechiae, Impaired ADP-induced platelet aggregation, Imp... OMIM:601399
Congenital Factor X Deficiency
Prolonged prothrombin time, Spontaneous hematomas, Gastrointestinal hemorrhage, Post-partum hemor... ORPHA:328
Neurofibromatosis-Noonan Syndrome
Prolonged bleeding time ORPHA:638
Myh9-Related Disease
Bruising susceptibility, Spontaneous, recurrent epistaxis, Prolonged bleeding time, Menorrhagia ORPHA:182050
Hermansky-Pudlak Syndrome 5
Impaired ADP-induced platelet aggregation, Menorrhagia, Epistaxis, Bruising susceptibility, Prolo... OMIM:614074
Combined Deficiency Of Factor V And Factor Viii
Prolonged prothrombin time, Gastrointestinal hemorrhage, Gingival bleeding, Prolonged bleeding fo... ORPHA:35909
Essential Thrombocythemia
Prolonged bleeding time, Abnormal bleeding, Bruising susceptibility ORPHA:3318
Deafness-Lymphedema-Leukemia Syndrome
Prolonged bleeding time, Bruising susceptibility, Intracranial hemorrhage ORPHA:3226
Klippel-Trénaunay Syndrome
Prolonged bleeding time, Gastrointestinal hemorrhage, Internal hemorrhage ORPHA:90308
Hermansky-Pudlak Syndrome 1
Gingival bleeding, Ecchymosis, Epistaxis, Hematochezia, Bruising susceptibility, Prolonged bleedi... OMIM:203300
Dentinogenesis Imperfecta
Bruising susceptibility, Prolonged bleeding time ORPHA:49042
Hemophilia B
Hematemesis, Prolonged prothrombin time, Gastrointestinal hemorrhage, Melena, Petechiae, Joint he... OMIM:306900
Pseudoxanthoma Elasticum-Like Disorder With Multiple Coagulation Factor Deficiency
Prolonged prothrombin time, Abnormal bleeding, Epistaxis OMIM:610842
Hermansky-Pudlak Syndrome 6
Impaired ADP-induced platelet aggregation, Impaired collagen-induced platelet aggregation, Ecchym... OMIM:614075
Osteogenesis Imperfecta, Type Xvi
Bruising susceptibility, Prolonged bleeding time OMIM:616229
Factor Xiii, B Subunit, Deficiency Of
Abnormal bleeding, Abnormal umbilical stump bleeding, Ecchymosis, Bruising susceptibility, Prolon... OMIM:613235
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1
Prolonged prothrombin time, Abnormal bleeding, Joint hemorrhage, Epistaxis, Cerebral hemorrhage, ... OMIM:277450
Wiskott-Aldrich Syndrome
Hematemesis, Spontaneous hematomas, Purpura, Petechiae, Abnormal platelet function, Gingival blee... ORPHA:906
Macs Syndrome
Prolonged bleeding time, Bruising susceptibility OMIM:613075
Mixed Connective Tissue Disease
Prolonged bleeding time, Gastrointestinal hemorrhage, Purpura ORPHA:809
Congenital Fibrinogen Deficiency
Prolonged prothrombin time, Abnormal bleeding, Gingival bleeding, Internal hemorrhage, Abnormal u... ORPHA:335
Dermatosparaxis Ehlers-Danlos Syndrome
Prolonged bleeding time ORPHA:1901
Hermansky-Pudlak Syndrome 2
Prolonged bleeding time, Impaired ADP-induced platelet aggregation OMIM:608233
Acquired Von Willebrand Syndrome
Prolonged prothrombin time, Gastrointestinal hemorrhage, Melena, Menorrhagia, Joint hemorrhage, E... ORPHA:99147
Acquired Purpura Fulminans
Prolonged prothrombin time, Macular purpura, Intracranial hemorrhage, Internal hemorrhage ORPHA:49566
Wiskott-Aldrich Syndrome
Hematemesis, Purpura, Melena, Petechiae, Gingival bleeding, Epistaxis, Prolonged bleeding time OMIM:301000
Infantile Liver Failure Syndrome 2
Prolonged prothrombin time OMIM:616483
Cog8-Cdg
Prolonged prothrombin time, Spontaneous hematomas ORPHA:95428
Noonan Syndrome 9
Prolonged prothrombin time OMIM:616559
Bile Acid Synthesis Defect, Congenital, 4
Prolonged prothrombin time, Hematochezia OMIM:214950
Relapsing Fever
Prolonged prothrombin time, Abnormal bleeding, Epistaxis ORPHA:91547
Hepatoportal Sclerosis
Prolonged prothrombin time, Gastrointestinal hemorrhage, Abnormal bleeding ORPHA:64743
Classical Ehlers-Danlos Syndrome
Prolonged bleeding time, Ecchymosis, Bruising susceptibility ORPHA:287
Hypermethioninemia Due To Adenosine Kinase Deficiency
Prolonged prothrombin time OMIM:614300
Cholestasis, Progressive Familial Intrahepatic, 5
Prolonged prothrombin time OMIM:617049
Liver Failure, Infantile, Transient
Prolonged prothrombin time OMIM:613070
Sialuria
Prolonged prothrombin time ORPHA:3166
Infantile Liver Failure Syndrome 3
Prolonged prothrombin time OMIM:618641
Cardiac-Urogenital Syndrome
Prolonged bleeding time OMIM:618280
Bile Acid Synthesis Defect, Congenital, 3
Prolonged prothrombin time, Hematochezia OMIM:613812
Monosomy 13Q34
Prolonged prothrombin time, Epistaxis, Hematochezia ORPHA:96168
Acyl-Coa Dehydrogenase 9 Deficiency
Prolonged prothrombin time, Cerebellar hemorrhage ORPHA:99901
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Prolonged prothrombin time ORPHA:367
Congenital Bile Acid Synthesis Defect Type 2
Prolonged prothrombin time ORPHA:79303
Congenital Factor Xiii Deficiency
Spontaneous hematomas, Post-partum hemorrhage, Oral cavity bleeding, Gingival bleeding, Delayed o... ORPHA:331
3-Methylglutaconic Aciduria, Type Viib
Prolonged prothrombin time, Abnormal bleeding OMIM:616271
S-Adenosylhomocysteine Hydrolase Deficiency
Prolonged prothrombin time ORPHA:88618
Hemophagocytic Lymphohistiocytosis, Familial, 1
Prolonged prothrombin time OMIM:267700
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Prolonged prothrombin time ORPHA:71212
Hellp Syndrome
Prolonged prothrombin time, Cerebral hemorrhage, Internal hemorrhage ORPHA:244242
Mitochondrial Complex Iv Deficiency, Nuclear Type 12
Prolonged prothrombin time, Intraventricular hemorrhage OMIM:619055
Combined Oxidative Phosphorylation Deficiency 37
Prolonged prothrombin time OMIM:618329
Hemophagocytic Lymphohistiocytosis, Familial, 2
Prolonged prothrombin time OMIM:603553
Celiac Disease, Susceptibility To, 1
Prolonged prothrombin time OMIM:212750
Congenital Disorder Of Glycosylation, Type Ia
Prolonged prothrombin time OMIM:212065
Congenital Disorder Of Glycosylation, Type It
Prolonged prothrombin time OMIM:614921
Alg12-Cdg
Prolonged prothrombin time ORPHA:79324
3-Hydroxy-3-Methylglutaric Aciduria
Prolonged prothrombin time ORPHA:20
Kasabach-Merritt Phenomenon
Prolonged prothrombin time, Petechiae, Purpura ORPHA:2330
Shwachman-Diamond Syndrome 2
Prolonged prothrombin time OMIM:617941
Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To
Prolonged prothrombin time OMIM:311250
Isolated Biliary Atresia
Prolonged prothrombin time ORPHA:30391
Abetalipoproteinemia
Prolonged prothrombin time, Abnormal bleeding ORPHA:14
Tyrosinemia, Type I
Prolonged prothrombin time, Gastrointestinal hemorrhage, Melena OMIM:276700
Marburg Hemorrhagic Fever
Prolonged prothrombin time, Abnormal bleeding, Petechiae, Internal hemorrhage, Subconjunctival he... ORPHA:99826
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Prolonged prothrombin time ORPHA:404454
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Prolonged prothrombin time ORPHA:309854
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Prolonged prothrombin time, Gastrointestinal hemorrhage, Abnormal bleeding ORPHA:247598
Acute Liver Failure
Prolonged prothrombin time, Gastrointestinal hemorrhage, Abnormal bleeding, Intracranial hemorrha... ORPHA:90062
Yellow Fever
Hematemesis, Prolonged prothrombin time, Abnormal bleeding, Internal hemorrhage, Excessive bleedi... ORPHA:99829
Primary Sclerosing Cholangitis
Prolonged prothrombin time ORPHA:171
Congenital Disorder Of Glycosylation, Type Iiw
Prolonged prothrombin time, Bleeding with minor or no trauma OMIM:619525

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for F13b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to F13b.

No publications found that use IMPC mice or data for F13b.

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MGI Allele Allele Type Produced
F13btm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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