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Gene: Cd68 MGI:88342

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Gene Summary

Name:
CD68 antigen
Synonyms:
gp110,  Scard1,  macrosialin,  Lamp4

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal locomotor behavior Cd68em1(IMPC)Bay HET   Early adult 6.05×10-05
preweaning lethality, incomplete penetrance Cd68em1(IMPC)Bay HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of left eye

15 Images

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Eye Morphology

VIP of right eye

15 Images

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Eye Morphology

VIP of left fundus

15 Images

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Eye Morphology

VIP of right fundus

15 Images

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Human diseases caused by Cd68 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd68 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Superior Transverse Scapular Ligament, Calcification Of, Familial
Ectopic ossification in ligament tissue OMIM:601708
Osteopenia And Sparse Hair
Osteopenia, Joint hypermobility OMIM:259690
12q14 microdeletion syndrome
Osteopoikilosis DECIPHER:76
Metaphyseal Modeling Abnormality, Skin Lesions, And Spastic Paraplegia
Increased bone mineral density OMIM:250500
Osteomesopyknosis
Increased bone mineral density OMIM:166450
Pyknoachondrogenesis
Increased bone mineral density OMIM:265880
Hypogonadotropic Hypogonadism 19 With Or Without Anosmia
Osteopenia, Osteoporosis OMIM:615269
Hypophosphatemic Rickets, Autosomal Recessive, 1
Rickets, Craniosynostosis, Hypophosphatemic rickets, Increased bone mineral density OMIM:241520
Osteosclerosis-Ichthyosis-Premature Ovarian Failure Syndrome
Increased bone mineral density ORPHA:75325
Osteoporosis
Osteoporosis OMIM:166710
Ossification Of The Posterior Longitudinal Ligament Of Spine
Increased bone mineral density, Ectopic ossification OMIM:602475
Osteopoikilosis And Dacryocystitis
Osteopoikilosis OMIM:166705
Dentin Dysplasia
Increased bone mineral density ORPHA:1653
Osteomesopyknosis
Increased bone mineral density, Abnormal cortical bone morphology ORPHA:2777
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Rickets, Generalized bone demineralization, Rickets of the lower limbs, Delayed epiphyseal ossifi... OMIM:600785
Eiken Syndrome
Abnormal bone ossification, Delayed epiphyseal ossification, Abnormal trabecular bone morphology,... ORPHA:79106
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
Hypophosphatemic Bone Disease
Rickets, Osteomalacia OMIM:146350
Hip Dysplasia, Beukes Type
Abnormality of bone mineral density, Abnormal bone ossification, Abnormal ossification involving ... ORPHA:2114
Gnathodiaphyseal Dysplasia
Osteopenia, Diaphyseal cortical sclerosis, Osteomyelitis, Increased susceptibility to fractures OMIM:166260
Hypophosphatasia, Adult
Rickets, Pathologic fracture, Osteomalacia, Recurrent fractures, Increased susceptibility to frac... OMIM:146300
Florid Cemento-Osseous Dysplasia
Multiple bony cystic lesions, Abnormal bone structure, Abnormal trabecular bone morphology, Mandi... ORPHA:83451
Axial Osteomalacia
Increased bone mineral density, Osteomalacia OMIM:109130
Tyrosinemia Type 1
Splenomegaly, Rickets of the lower limbs ORPHA:882
Hypophosphatemic Rickets, Autosomal Dominant
Rickets, Osteomalacia, Hypophosphatemic rickets OMIM:193100
Dacryocystitis-Osteopoikilosis Syndrome
Increased bone mineral density, Osteopoikilosis ORPHA:1562
Van Buchem Disease
Increased bone mineral density, Cranial hyperostosis, Thickened cortex of long bones OMIM:239100
Angioosteohypotrophic Syndrome
Abnormal trabecular bone morphology, Thin bony cortex ORPHA:75508
Hypercholanemia, Familial 1
Rickets OMIM:607748
Renal Tubular Acidosis, Proximal
Rickets, Osteomalacia OMIM:179830
Bile Acid Conjugation Defect 1
Rickets OMIM:619232
Ghosal Hematodiaphyseal Dysplasia
Increased bone mineral density, Refractory anemia, Myelofibrosis, Bone marrow hypocellularity, Th... OMIM:231095
Hypogonadotropic Hypogonadism 20 With Or Without Anosmia
Osteopenia, Osteoporosis OMIM:615270
Renal Tubular Acidosis Iii
Rickets, Osteomalacia OMIM:267200
Osteosclerosis With Ichthyosis And Fractures
Increased bone mineral density, Recurrent fractures, Cortical thickening of long bone diaphyses OMIM:166740
Hypophosphatemic Rickets, X-Linked Recessive
Rickets, Hypophosphatemic rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Osteo... OMIM:300554
Body Mass Index Quantitative Trait Locus 20
Increased bone mineral density OMIM:618406
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Recurrent fractures, Thin bony ... OMIM:600081
Intermediate Osteopetrosis
Anemia, Abnormality of bone mineral density, Recurrent fractures, Cortical sclerosis, Hepatosplen... ORPHA:210110
Idiopathic Hypercalciuria
Osteopenia, Osteoporosis ORPHA:2197
Osteopetrosis, Autosomal Recessive 7
Femur fracture, Osteopetrosis, Anemia, Decreased circulating IgG level, Abnormal trabecular bone ... OMIM:612301
Autosomal Dominant Hypophosphatemic Rickets
Rickets, Osteomalacia, Iron deficiency anemia, Tooth abscess ORPHA:89937
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Rickets, Hypophosphatemic rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Recur... OMIM:241530
Hypocalcemic Vitamin D-Resistant Rickets
Bone cyst, Abnormal bone structure, Coarse metaphyseal trabecularization, Osteomalacia, Recurrent... ORPHA:93160
Renal Tubular Acidosis, Distal, 3, With Or Without Sensorineural Hearing Loss
Rickets OMIM:602722
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Rickets, Reticulocytosis, Hepatosplenomegaly, Decreased mean corpuscular volume, Hemolytic anemia OMIM:611590
Autosomal Recessive Hypophosphatemic Rickets
Pseudo-fractures, Hypophosphatemic rickets, Rickets of the lower limbs, Increased bone mineral de... ORPHA:289176
Renal Tubular Acidosis, Distal, 1
Osteomalacia, Pathologic fracture OMIM:179800
Fanconi Renotubular Syndrome 2
Osteopenia, Rickets, Recurrent fractures, Osteomalacia OMIM:613388
Cystinosis, Late-Onset Juvenile Or Adolescent Nephropathic Type
Rickets OMIM:219900
Dent Disease 1
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Osteomalacia, Recurrent fractur... OMIM:300009
Cholestasis, Progressive Familial Intrahepatic, 1
Osteopenia, Rickets, Splenomegaly OMIM:211600
Hereditary Hypophosphatemic Rickets With Hypercalciuria
Osteomalacia, Reduced bone mineral density, Pathologic fracture, Hypophosphatemic rickets ORPHA:157215
Fanconi Renotubular Syndrome 3
Rickets OMIM:615605
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Recurrent fractures, Thin bony ... OMIM:264700
Vitamin D-Dependent Rickets, Type 2A
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Recurrent fractures, Thin bony ... OMIM:277440
Hypocalcemic Vitamin D-Dependent Rickets
Rickets, Delayed epiphyseal ossification, Leukocytosis, Splenomegaly, Sparse bone trabeculae, Ost... ORPHA:289157
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia
Rickets, Osteoporosis OMIM:560000
Fanconi Renotubular Syndrome 1
Rickets, Osteomalacia OMIM:134600
Dermatosparaxis Ehlers-Danlos Syndrome
Rickets, Osteopenia, Osteoporosis, Joint stiffness, Osteomalacia, Joint hypermobility ORPHA:1901
Rod-Cone Dystrophy, Sensorineural Deafness, And Fanconi-Type Renal Dysfunction
Rickets, Recurrent fractures OMIM:268315
Hypophosphatemic Rickets And Hyperparathyroidism
Rickets, Hypophosphatemic rickets OMIM:612089
Myelofibrosis
Hemophagocytosis, Myeloproliferative disorder, Myelofibrosis, Splenomegaly, Extramedullary hemato... OMIM:254450
Infantile Systemic Hyalinosis
Osteopenia, Osteoporosis, Joint stiffness, Camptodactyly of finger, Osteomalacia, Recurrent fract... ORPHA:2176
Bile Acid Synthesis Defect, Congenital, 1
Rickets, Splenomegaly OMIM:607765
Dent Disease
Rickets, Delayed epiphyseal ossification, Sparse bone trabeculae, Osteomalacia, Recurrent fractur... ORPHA:1652
Rothmund-Thomson Syndrome
Osteopenia, Aplastic anemia, Reduced bone mineral density, Neutropenia, Anemia, Abnormal trabecul... ORPHA:2909
Hypophosphatemic Rickets, X-Linked Dominant
Rickets, Hypophosphatemic rickets, Hepatosplenomegaly, Osteoarthritis, Osteomalacia OMIM:307800
Rothmund-Thomson Syndrome Type 2
Osteopenia, Finger symphalangism, Aplastic anemia, Neutropenia, Anemia, Abnormal trabecular bone ... ORPHA:221016
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Rickets OMIM:616026
Fibrous Dysplasia Of Bone
Rickets, Pathologic fracture, Abnormal bone structure, Cortical irregularity, Osteolysis, Osteoma... ORPHA:249
Rothmund-Thomson Syndrome Type 1
Osteopenia, Finger symphalangism, Aplastic anemia, Anemia, Abnormal trabecular bone morphology, L... ORPHA:221008
Cystinosis
Rickets ORPHA:213
Pancreatic Triacylglycerol Lipase Deficiency
Rickets, Osteomalacia, Iron deficiency anemia, Osteoporosis ORPHA:309031
Congenital Bile Acid Synthesis Defect Type 2
Rickets, Extramedullary hematopoiesis ORPHA:79303
Celiac Disease, Susceptibility To, 1
Rickets, Thrombocytosis, Macrocytic anemia, Iron deficiency anemia, Osteoporosis, Decreased circu... OMIM:212750
X-Linked Hypophosphatemia
Rickets, Reduced bone mineral density, Vertebral hyperostosis, Arthritis, Limitation of joint mob... ORPHA:89936
Mccune-Albright Syndrome
Aneurysmal bone cyst, Pancytopenia, Polyostotic fibrous dysplasia, Bone marrow hypocellularity, M... ORPHA:562
Fanconi-Bickel Syndrome
Rickets, Osteopenia ORPHA:2088
Hypocalciuric Hypercalcemia, Familial, Type Iii
Osteomalacia OMIM:600740
Neu-Laxova Syndrome
Rickets, Osteopenia, Osteoporosis, Flexion contracture, Osteomalacia, Arthrogryposis multiplex co... ORPHA:2671
Fanconi-Bickel Syndrome
Rickets, Osteomalacia OMIM:227810
Distal Renal Tubular Acidosis
Rickets, Reduced bone mineral density, Osteomalacia, Hemolytic anemia, Increased susceptibility t... ORPHA:18
Immunodeficiency 82 With Systemic Inflammation
Decreased circulating total IgG, Anemia, Arthritis, B lymphocytopenia, Decreased proportion of na... OMIM:619381
Occipital Horn Syndrome
Rickets, Osteopenia, Synostosis of joints, Osteoporosis, Osteomalacia, Joint hypermobility, Osteo... ORPHA:198
Rajab Interstitial Lung Disease With Brain Calcifications 1
Rickets, Osteopenia, Reduced bone mineral density, Anemia, Pancytopenia, Joint hypermobility, Thi... OMIM:613658
Familial Hypocalciuric Hypercalcemia
Osteomalacia ORPHA:405
Infantile Nephropathic Cystinosis
Rickets ORPHA:411629
Primary Fanconi Renotubular Syndrome
Osteomalacia, Hypophosphatemic rickets, Increased susceptibility to fractures ORPHA:3337
Wilson Disease
Anemia, Osteoporosis, Thrombocytopenia, Splenomegaly, Osteoarthritis, Osteomalacia, Joint hypermo... OMIM:277900
Lowe Oculocerebrorenal Syndrome
Rickets, Pathologic fracture, Osteomalacia, Camptodactyly of finger, Joint hypermobility, Joint c... OMIM:309000
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii
Rickets, Osteopenia, Abnormally ossified vertebrae, Osteoporosis, Osteomalacia ORPHA:2636
Oculocerebrorenal Syndrome Of Lowe
Anemia, Arthritis, Joint stiffness, Thrombocytopenia, Osteomalacia, Joint hypermobility, Recurren... ORPHA:534
Cystinosis, Nephropathic
Rickets, Hypophosphatemic rickets, Splenomegaly OMIM:219800
Hypomagnesemia 3, Renal
Rickets OMIM:248250
Generalized Arterial Calcification Of Infancy
Osteomalacia, Abnormal calcification of the carpal bones, Fused cervical vertebrae, Hypophosphate... ORPHA:51608

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd68

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd68.

No publications found that use IMPC mice or data for Cd68.

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MGI Allele Allele Type Produced
Cd68tm1(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cd68tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Cd68tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd68tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Cd68em1(IMPC)Bay Exon Deletion Mice

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