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Genes Phenotypes Help, News, Blog

Gene: Angptl8 MGI:3643534

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Gene Summary

Name:
angiopoietin-like 8
Synonyms:
Gm6484,  Lipasin,  Rifl

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Angptl8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Angptl8 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hypertriglyceridemia 2
Hypercholesterolemia, Hypertriglyceridemia OMIM:619324
Glycogen Storage Disease Vi
Elevated hepatic transaminase, Hypertriglyceridemia, Failure to thrive in infancy, Postnatal grow... OMIM:232700
Obesity Due To Melanocortin 4 Receptor Deficiency
Hypertriglyceridemia, Childhood-onset truncal obesity, Obesity, Increased adipose tissue ORPHA:71529
Lipodystrophy, Familial Partial, Type 6
Lipodystrophy, Elevated circulating creatine kinase concentration, Hyperlipidemia, Abdominal obes... OMIM:615980
Citrullinemia, Type Ii, Neonatal-Onset
Hypertyrosinemia, Decreased HDL cholesterol concentration, Hypertriglyceridemia, Elevated circula... OMIM:605814
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Decreased HDL cholesterol concentration, Hypoalbuminemia, Elevated gamma-glutamyltransferase leve... ORPHA:247598
Lipodystrophy, Partial, Acquired, Susceptibility To
Loss of subcutaneous adipose tissue from upper limbs, Abnormal circulating lipid concentration, P... OMIM:608709
Lipodystrophy Due To Peptidic Growth Factors Deficiency
Reduced subcutaneous adipose tissue, Lipoatrophy, Lipodystrophy, Cachexia, Flexion contracture, W... ORPHA:1979
Parenteral Nutrition-Associated Cholestasis
Elevated hepatic transaminase, Small for gestational age, Portal hypertension, Conjugated hyperbi... ORPHA:567983
Stiff Skin Syndrome
Abnormal circulating lipid concentration, Lipoatrophy, Short stature ORPHA:2833
Idiopathic Steroid-Resistant Nephrotic Syndrome
Hypertriglyceridemia, Growth delay, Hypoalbuminemia, Hypercholesterolemia, Abnormal circulating l... ORPHA:567548
Subaortic Stenosis-Short Stature Syndrome
Inguinal hernia, Abnormal circulating lipid concentration, Short stature, Obesity ORPHA:3191
Familial Cervical Artery Dissection
Abnormal circulating lipid concentration, Abnormality of connective tissue ORPHA:36382
Acquired Generalized Lipodystrophy
Hypertriglyceridemia, Abnormal circulating lipid concentration, Panniculitis, Generalized lipodys... ORPHA:79086
Apolipoprotein A-I Deficiency
Xanthelasma, Decreased HDL cholesterol concentration, Abnormal circulating lipid concentration ORPHA:425
Kennedy Disease
Abnormal circulating lipid concentration ORPHA:481
Griscelli Syndrome
Jaundice, Abnormal circulating lipid concentration, Short stature, Hepatitis ORPHA:381
Overlap Myositis
Elevated hepatic transaminase, Abnormal circulating lipid concentration, Abnormality of connectiv... ORPHA:206572
Adult-Onset Still Disease
Elevated hepatic transaminase, Abnormal circulating lipid concentration, Hepatitis, Elevated circ... ORPHA:829
Short Stature, Microcephaly, And Endocrine Dysfunction
Inguinal hernia, Short stature, Truncal obesity, Disproportionate short-limb short stature, Intra... OMIM:616541
Chronic Visceral Acid Sphingomyelinase Deficiency
Decreased HDL cholesterol concentration, Hypertriglyceridemia, Short stature, Hyperlipidemia, Inc... ORPHA:77293
Primary Biliary Cholangitis
Portal hypertension, Conjugated hyperbilirubinemia, Jaundice, Hepatitis, Elevated circulating alk... ORPHA:186
Insulin-Resistance Syndrome Type B
Abnormal circulating lipid concentration, Abnormality of body weight, Abnormal circulating fatty-... ORPHA:2298

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Angptl8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Angptl8.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance. Journal of lipid research (April 2017) Angptl8tm1(KOMP)Vlcg PMC5454515
Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. Journal of lipid research (May 2015) Angptl8tm1(KOMP)Vlcg PMC4479334
ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell (October 2014) Angptl8tm1(KOMP)Vlcg PMC4243040
Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America (September 2013) Angptl8tm1(KOMP)Vlcg PMC3791734

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Angptl8tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Angptl8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Angptl8em1(IMPC)Bay Intra-exon deletion Mice

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