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Gene: Mir128-2 MGI:3618709

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
microRNA 128-2
Synonyms:
mmu-mir-128-2,  Mirn128b,  mmu-mir-128b,  mir-128b,  Mirn128-2,  mir 128b

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mir128-2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mir128-2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Attention Deficit-Hyperactivity Disorder 8
Attention deficit hyperactivity disorder OMIM:619957
Schizophrenia 15
Hyperactivity OMIM:613950
Developmental And Epileptic Encephalopathy 104
Epileptic spasm, Agitation, Hyperactivity, Seizure, Bilateral tonic-clonic seizure, Tonic seizure... OMIM:619970
Intellectual Developmental Disorder, Autosomal Dominant 50, With Behavioral Abnormalities
Attention deficit hyperactivity disorder, Seizure, Motor stereotypy OMIM:617787
Intellectual Developmental Disorder, Autosomal Recessive 2
Attention deficit hyperactivity disorder, Self-injurious behavior, Seizure OMIM:607417
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity, Seizure, Bruxism, Aggressive behavior OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Seizure, Bruxism, Aggressive behavior ORPHA:356996
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity, Seizure, Motor stereotypy OMIM:300271
Developmental And Epileptic Encephalopathy 43
Hyperactivity, Infantile spasms, Impulsivity, Bilateral tonic-clonic seizure, Atypical absence se... OMIM:617113
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Female Restricted Epilepsy With Intellectual Disability
Generalized non-motor (absence) seizure, Generalized clonic seizure, Generalized myoclonic seizur... ORPHA:101039
Gilles De La Tourette Syndrome
Compulsive behaviors, Phonic tics, Motor tics, Attention deficit hyperactivity disorder, Self-mut... OMIM:137580
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity, Seizure, Infantile spasms, Self-injurious behavior, Aggressive behavior OMIM:619031
Megalencephalic Leukoencephalopathy With Subcortical Cysts 4, Remitting
Hyperactivity, Seizure, Impulsivity, Gait ataxia, Dysphagia, Status epilepticus OMIM:620448
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Seizure, Impulsivity, Febrile seizure (within the age range of 3 months to 6 years... OMIM:301008
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity, Febrile seizure (within the age range of 3 months to 6 years) OMIM:300454
Developmental And Epileptic Encephalopathy 9
Generalized non-motor (absence) seizure, Generalized myoclonic seizure, Focal-onset seizure, Bila... OMIM:300088
Intellectual Developmental Disorder, Autosomal Dominant 69
Attention deficit hyperactivity disorder, Bilateral tonic-clonic seizure OMIM:617863
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity, Seizure ORPHA:436151
Developmental And Epileptic Encephalopathy 24
Generalized non-motor (absence) seizure, Focal-onset seizure, Bilateral tonic-clonic seizure, Feb... OMIM:615871
Stxbp1-Related Encephalopathy
Epileptic spasm, Generalized myoclonic seizure, Inability to walk, Hyperactivity, Focal motor sei... ORPHA:599373
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity, Inflexible adherence to routines, Bilateral tonic-clonic seizure OMIM:301076
Smith-Magenis syndrome
Hyperactivity, Self-mutilation, Motor stereotypy DECIPHER:8
Hyperprolinemia, Type I
Hyperactivity, Seizure, Ataxia, Motor stereotypy, Status epilepticus, Aggressive behavior OMIM:239500
Lennox-Gastaut Syndrome
Generalized myoclonic seizure, Focal-onset seizure, Falls, Hyperactivity, Bilateral tonic-clonic ... ORPHA:2382
Guanidinoacetate Methyltransferase Deficiency
Generalized myoclonic seizure, Hyperactivity, Seizure, Athetosis, Bilateral tonic-clonic seizure,... ORPHA:382
Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
Hyperactivity, Seizure, Generalized-onset seizure, Inability to walk OMIM:616657
Hartnup Disorder
Hyperactivity, Seizure, Episodic ataxia, Attention deficit hyperactivity disorder, Generalized to... OMIM:234500
Intellectual Developmental Disorder, Autosomal Dominant 33
Hyperactivity OMIM:616311
Microcephaly, Seizures, And Developmental Delay
Hyperactivity, Seizure, Ataxia OMIM:613402
Landau-Kleffner Syndrome
Generalized non-motor (absence) seizure, Generalized clonic seizure, Steppage gait, Focal myoclon... ORPHA:98818
Epilepsy, Progressive Myoclonic, 12
Difficulty walking, Bilateral tonic-clonic seizure, Ataxia, Myoclonus, Attention deficit hyperact... OMIM:619191
Intellectual Developmental Disorder, X-Linked 109
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... OMIM:309548
Fraxe Intellectual Disability
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... ORPHA:100973
Intellectual Developmental Disorder, X-Linked 111
Hyperactivity, Seizure, Compulsive behaviors, Phonic tics, Unsteady gait, Aggressive behavior OMIM:301107
Glycine Encephalopathy 1
Hyperactivity, Seizure, Impulsivity, Restlessness, Myoclonus, Aggressive behavior OMIM:605899
Developmental And Epileptic Encephalopathy 109
Typical absence seizure, Hyperactivity, Bilateral tonic-clonic seizure, Gait ataxia, Tonic seizur... OMIM:620145
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum
Generalized myoclonic seizure, Inability to walk, Hyperactivity, Gait disturbance, Gait ataxia, B... OMIM:618090
Intellectual Developmental Disorder, X-Linked 101
Hyperactivity, Seizure OMIM:300928
Intellectual Developmental Disorder, Autosomal Dominant 67
Hyperactivity, Seizure, Compulsive behaviors, Motor tics, Attention deficit hyperactivity disorder OMIM:619927
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Broad-based gait, Hyperactivity, Seizure, Motor stereotypy, Aggressive behavior OMIM:619470
Succinic Semialdehyde Dehydrogenase Deficiency
Generalized non-motor (absence) seizure, Generalized myoclonic seizure, Hyperactivity, Seizure, B... OMIM:271980
Mannosidosis, Beta A, Lysosomal
Hyperactivity, Seizure, Aggressive behavior OMIM:248510
X-Linked Intellectual Disability, Stocco Dos Santos Type
Hyperactivity, Seizure ORPHA:85288
Intellectual Developmental Disorder, Autosomal Recessive 38
Hyperactivity, Seizure, Recurrent hand flapping, Febrile seizure (within the age range of 3 month... OMIM:615516
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly
Inappropriate behavior, Nail-biting, Hyperactivity, Seizure, Generalized-onset seizure, Bilateral... OMIM:619827
Lodder-Merla Syndrome, Type 2, With Developmental Delay And With Or Without Cardiac Arrhythmia
Hyperactivity, Attention deficit hyperactivity disorder, Seizure OMIM:617182
Encephalopathy, Progressive, With Or Without Lipodystrophy
Hyperactivity, Seizure, Ataxia, Myoclonus OMIM:615924
Intellectual Developmental Disorder, X-Linked 104
Hyperactivity, Seizure, Ataxia, Aggressive behavior OMIM:300983
Intellectual Developmental Disorder, X-Linked, Syndromic, Stocco Dos Santos Type
Hyperactivity, Seizure, Bruxism OMIM:300434
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Focal aware seizure, Generalized-onset seizure, Bilateral tonic-clonic seizure wit... OMIM:610042
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations
Hyperactivity, Seizure, Generalized-onset seizure, Impulsivity, Bilateral tonic-clonic seizure, S... OMIM:604317
Rasmussen Subacute Encephalitis
Repeated focal motor seizures, Epilepsia partialis continua, Epileptic spasm, Focal-onset seizure... ORPHA:1929
Neurodevelopmental Disorder With Language Delay And Behavioral Abnormalities, With Or Without Seizures
Hyperactivity, Seizure, Bilateral tonic-clonic seizure, Febrile seizure (within the age range of ... OMIM:620292
Intellectual Developmental Disorder, Autosomal Recessive 74
Hyperactivity, Seizure OMIM:617169
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Inability to walk, Hyperactivity, Seizure, Motor stereotypy, Self-injurious behavior, Bruxism, Pa... OMIM:618718
Clcn4-Related X-Linked Intellectual Disability Syndrome
Generalized non-motor (absence) seizure, Progressive cerebellar ataxia, Hyperactivity, Seizure, I... ORPHA:485350
Xq25 Microduplication Syndrome
Hyperactivity, Seizure ORPHA:521258
Morm Syndrome
Hyperactivity, Aggressive behavior ORPHA:75858
Developmental And Epileptic Encephalopathy 103
Generalized non-motor (absence) seizure, Eyelid myoclonus, Epileptic spasm, Hyperactivity, Bilate... OMIM:619913
Intellectual Developmental Disorder, Autosomal Dominant 45
Generalized non-motor (absence) seizure, Hyperactivity, Recurrent hand flapping, Bilateral tonic-... OMIM:617600
Juvenile Huntington Disease
Progressive cerebellar ataxia, Broad-based gait, Hyperactivity, Seizure, Gait ataxia, Ataxia, Myo... ORPHA:248111
Aminoacylase 1 Deficiency
Hyperactivity, Seizure, Bilateral tonic-clonic seizure OMIM:609924
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Broad-based gait, Hyperactivity, Seizure, Polyphagia, Inappropriate laughter, Ataxia ORPHA:411515
Phenylketonuria
Hyperactivity, Seizure, Compulsive behaviors, Attention deficit hyperactivity disorder, Self-muti... OMIM:261600
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Hyperactivity, Seizure, Generalized-onset seizure, Status epilepticus, Self-biting OMIM:618314
Intellectual Developmental Disorder, X-Linked 107
Hyperactivity, Attention deficit hyperactivity disorder, Seizure, Aggressive behavior OMIM:301013
8p23.1 deletion syndrome
Hyperactivity DECIPHER:39
Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder
Inability to walk, Hyperactivity, Seizure, Impulsivity, Gait ataxia, Dysphagia, Aggressive behavior ORPHA:500180
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Anorexia, Abnormal fear-induced behavior, Broad-based gait, Hyperactivity, Seizure, Shuffling gai... ORPHA:3077
Neurodevelopmental Disorder With Microcephaly And Movement Abnormalities
Hyperactivity, Seizure, Waddling gait, Impulsivity, Gait ataxia, Self-mutilation, Paroxysmal burs... OMIM:620445
Usmani-Riazuddin Syndrome, Autosomal Dominant
Hyperactivity, Seizure, Compulsive behaviors, Self-injurious behavior, Aggressive behavior OMIM:619467
Intellectual Developmental Disorder, X-Linked 30
Generalized non-motor (absence) seizure, Agitation, Hyperactivity, Seizure, Bilateral tonic-cloni... OMIM:300558
Chromosome Xq25 Duplication Syndrome
Hyperactivity, Seizure OMIM:300979
Late Infantile Neuronal Ceroid Lipofuscinosis
Obsessive-compulsive trait, Generalized myoclonic seizure, Focal-onset seizure, Typical absence s... ORPHA:168491
X-Linked Intellectual Disability-Hypotonia-Movement Disorder Syndrome
Hyperactivity, Seizure, Broad-based gait, Aggressive behavior ORPHA:457260
Neurodevelopmental Disorder With Or Without Autism Or Seizures
Hyperactivity, Seizure, Infantile spasms, Tonic seizure OMIM:619239
Intellectual Developmental Disorder, X-Linked 21
Hyperactivity, Seizure, Impulsivity OMIM:300143
Intellectual Developmental Disorder, Autosomal Recessive 13
Hyperactivity, Seizure, Bruxism, Recurrent hand flapping OMIM:613192
Intellectual Developmental Disorder, Autosomal Dominant 7
Hyperactivity, Seizure, Stereotypical hand wringing, Gait disturbance, Febrile seizure (within th... OMIM:614104
Intellectual Developmental Disorder, Autosomal Recessive 39
Hyperactivity, Motor stereotypy, Aggressive behavior OMIM:615541
Myoclonic-Astatic Epilepsy
Generalized non-motor (absence) seizure, Simple febrile seizure, Focal-onset seizure, Generalized... ORPHA:1942
2Q23.1 Microdeletion Syndrome
Hyperactivity, Seizure, Polyphagia, Ataxia, Motor stereotypy, Self-injurious behavior, Paroxysmal... ORPHA:228402
Fragile X Syndrome
Hyperactivity, Seizure, Recurrent hand flapping, Self-biting OMIM:300624
Neurodevelopmental Disorder With Microcephaly, Movement Abnormalities, And Seizures
Inability to walk, Hyperactivity, Self-injurious behavior, Choreoathetosis, Aggressive behavior OMIM:620023
Developmental Delay, Language Impairment, And Ocular Abnormalities
Hyperactivity, Frequent temper tantrums, Impulsivity, Motor stereotypy, Attention deficit hyperac... OMIM:620141
Hyperlysinemia, Type I
Hyperactivity, Dysdiadochokinesis, Febrile seizure (within the age range of 3 months to 6 years),... OMIM:238700
Cntnap2-Related Developmental And Epileptic Encephalopathy
Abnormal temper tantrums, Focal-onset seizure, Hyperactivity, Seizure, Stereotypical hand wringin... ORPHA:163681
Intellectual Developmental Disorder, X-Linked 98
Generalized non-motor (absence) seizure, Generalized myoclonic seizure, Hyperactivity, Infantile ... OMIM:300912
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion
Gait imbalance, Tongue thrusting, Broad-based gait, Hyperactivity, Seizure, Recurrent hand flappi... ORPHA:98794
Adenylosuccinase Deficiency
Inability to walk, Hyperactivity, Seizure, Gait ataxia, Inappropriate laughter, Myoclonus, Self-m... OMIM:103050
Angelman Syndrome
Generalized myoclonic seizure, Inability to walk, Tongue thrusting, Broad-based gait, Hyperactivi... ORPHA:72
X-Linked Creatine Transporter Deficiency
Hyperactivity, Seizure, Athetosis, Ataxia, Self-mutilation ORPHA:52503
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Abnormal temper tantrums, Hyperactivity, Seizure, Recurrent hand flapping, Motor stereotypy, Atte... ORPHA:449291
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity, Aggressive behavior ORPHA:85327
Histidinemia
Hyperactivity ORPHA:2157
Neurodegeneration With Brain Iron Accumulation 2B
Hyperactivity, Dysdiadochokinesis, Seizure, Impulsivity, Gait ataxia, Dysphagia, Dysmetria OMIM:610217
Early Infantile Epileptic Encephalopathy
Generalized non-motor (absence) seizure, Generalized clonic seizure, Focal-onset seizure, Hyperac... ORPHA:1934
Microcephaly 29, Primary, Autosomal Recessive
Hyperactivity, Seizure, Ataxia OMIM:620047
Argininemia
Spastic gait, Seizure, Hyperactivity, Anorexia OMIM:207800
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Hyperactivity, Seizure, Ataxia, Choreoathetosis, Aggressive behavior OMIM:612716
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hair-pulling, Hyperactivity, Infantile spasms, Bilateral tonic-clonic seizure, Myoclonic spasms, ... ORPHA:447997
Familial Gestational Hyperthyroidism
Hyperactivity, Agitation ORPHA:99819

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mir128-2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mir128-2.

No publications found that use IMPC mice or data for Mir128-2.

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