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Gene: Cd226 MGI:3039602

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
CD226 antigen
Synonyms:
Pta1,  DNAM1,  DNAM-1,  TLiSA1

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cd226 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd226 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Monocyte Chemotactic Disorder
Cutaneous anergy, Chronic mucocutaneous candidiasis OMIM:252250
Wiskott-Aldrich Syndrome 2
Defective T cell proliferation, Eczema, Reduced natural killer cell activity OMIM:614493
Severe Combined Immunodeficiency, X-Linked
Skin rash, Pneumonia, Reduced natural killer cell activity, Recurrent pneumonia, Agammaglobulinem... OMIM:300400
Retinal Telangiectasia And Hypogammaglobulinemia
Reduced delayed hypersensitivity, Decreased circulating IgG level OMIM:267900
Immunodeficiency 14B, Autosomal Recessive
Reduced natural killer cell activity, Recurrent pneumonia, Decreased circulating total IgM, Infla... OMIM:619281
Immunodeficiency 20
Recurrent otitis media, Recurrent sinusitis, Reduced natural killer cell activity OMIM:615707
Lymphoproliferative Syndrome, X-Linked, 1
Dysgammaglobulinemia, Reduced natural killer cell activity, Fulminant hepatitis, Lymphoma, Decrea... OMIM:308240
Immunodeficiency 81
Recurrent cutaneous abscess formation, Skin rash, Reduced natural killer cell activity, Reduced a... OMIM:619374
Hemophagocytic Lymphohistiocytosis, Familial, 3
Reduced natural killer cell activity OMIM:608898
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Colitis, Abnormal natural killer cell physiology, Recurrent sinusitis, Decreased circulating anti... OMIM:613101
Immunodeficiency, Common Variable, 2
Impaired T cell function, Recurrent pneumonia, Lymphoma, Bronchiectasis, Neoplasm, Conjunctivitis... OMIM:240500
Autoimmune Lymphoproliferative Syndrome, Type Iii
Lymphoproliferative disorder, Reduced natural killer cell activity, Arthritis, Membranous nephrop... OMIM:615559
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Abnormality of T cell physiology OMIM:308220
Autoinflammation With Infantile Enterocolitis
Skin rash, Enterocolitis, Reduced natural killer cell activity OMIM:616050
Ectodermal Dysplasia And Immunodeficiency 1
Dysgammaglobulinemia, Reduced natural killer cell activity, Increased circulating IgA level, Incr... OMIM:300291
Familial Hemophagocytic Lymphohistiocytosis
Skin rash, Maculopapular exanthema, Reduced natural killer cell activity, Decreased circulating a... ORPHA:540
Wiskott-Aldrich Syndrome
Lymphoproliferative disorder, Eczema, Increased circulating IgA level, Reduced natural killer cel... OMIM:301000
Hermansky-Pudlak Syndrome 2
Reduced natural killer cell activity, Recurrent pneumonia, Impaired ADP-induced platelet aggregat... OMIM:608233
Hemophagocytic Lymphohistiocytosis, Familial, 2
Skin rash, Infectious encephalitis, Reduced natural killer cell activity OMIM:603553

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd226

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd226.

No publications found that use IMPC mice or data for Cd226.

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MGI Allele Allele Type Produced
Cd226tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd226tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Cd226tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Cd226tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, ES Cells
Cd226tm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice

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