Gene: Leprot

Order

Name leptin receptor overlapping transcript

Synonyms
  • OB-RGRP
  • Obrgrp

Status ES CellsMice
tm2a
Mice
tm2b
phenotype data available

Links MGI:2687005    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Leprot

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Leprot data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased total body fat amount Leprottm2a(KOMP)Wtsi HOM Female Male postnatal 5.87E-5
increased bone mineral content Leprottm2a(KOMP)Wtsi HOM Female Male postnatal 7.67E-5
decreased circulating iron level Leprottm2a(KOMP)Wtsi HOM Male postnatal 7.75E-5
increased circulating iron level Leprottm2a(KOMP)Wtsi HOM Female postnatal 7.75E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No
Aorta 4 No
Blood vessel 4 No
Bone 4 No
Brain 4 No
Brainstem 4 No
Brown adipose tissue 4 No
Cartilage tissue 4 No
Cerebellum 4 No
Cerebral cortex 4 No
Eye 4 No
Gall bladder 4 No
Heart 4 No
Hippocampus 4 No
Hypothalamus 4 No
Kidney 4 No (18/584)
Large intestine 4 No (10/584)
Liver 4 No
Lower urinary tract 4 No
Lung 4 No
Lymph node 4 No
Mammary gland 4 No
Esophagus 4 No
Olfactory lobe 4 No
Ovary 4 No (1/584)
Oviduct 4 No
Pancreas 4 No (5/584)
Parathyroid gland 4 No
Peripheral nervous system 4 No
Peyer's patch 4 No
Pituitary gland 4 No
Prostate gland 4 No (12/584)
Skeletal muscle tissue 4 No
Skin 4 No
Small intestine 4 No (9/584)
Spinal cord 4 No
Spleen 4 No (2/584)
Stomach 4 No (12/584)
Striatum 4 No
Testis 4 No (2/584) (1/4)
Thymus 4 No
Thyroid gland 4 No (15/584)
Trachea 4 No
Uterus 4 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse reproductive system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (2)
  • Leprottm2a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Leprottm2b(KOMP)Wtsi
    testis, HET, Male, WTSI
reproductive system (2)
  • Leprottm2a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Leprottm2b(KOMP)Wtsi
    testis, HET, Male, WTSI
trunk (2)
  • Leprottm2a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Leprottm2b(KOMP)Wtsi
    testis, HET, Male, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Skull Lateral Orientation
    28 Images
  • X-ray: XRay Images Dorso Ventral
    84 Images
  • X-ray: XRay Images Forepaw
    28 Images
  • X-ray: XRay Images Lateral Orientation
    56 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    28 Images
  • Eye Morphology: Images Ophthalmoscopy
    2 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    6 Images
  • Eye Morphology: Images Slit Lamp
    3 Images
Legacy Phenotype Associated Images
Xray (140)
  • Leprottm2a(KOMP)Wtsi
    HOM, Female, WTSI
  • Leprottm2a(KOMP)Wtsi
    HOM, Female, WTSI
  • Leprottm2a(KOMP)Wtsi
    HOM, Female, WTSI
  • Leprottm2a(KOMP)Wtsi
    HOM, Female, WTSI
  • Leprottm2a(KOMP)Wtsi
    HOM, Female, WTSI

show all 140 images

Eye Morphology (5)
  • Leprottm2a(KOMP)Wtsi
    abnormal retinal pigmentation, HOM, Male, WTSI
  • Leprottm2b(KOMP)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI
  • Leprottm2a(KOMP)Wtsi
    abnormal retinal pigmentation, HOM, Male, WTSI
  • Leprottm2b(KOMP)Wtsi
    abnormal cornea morphology, HOM, Male, WTSI
  • Leprottm2b(KOMP)Wtsi
    Fused cornea and lens, HOM, Female, WTSI
Skin Histopathology (1)
  • Leprottm2a(KOMP)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Leprottm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Leprottm2b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Leprottm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene