Gene: Zfyve28

Order

Name zinc finger, FYVE domain containing 28

Synonyms 9630058O20Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2684992    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Zfyve28

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Zfyve28 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased circulating iron level Zfyve28tm1b(EUCOMM)Wtsi HOM Female postnatal 1.28E-6
increased caudal vertebrae number Zfyve28tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.02E-5
decreased circulating LDL cholesterol level Zfyve28tm1b(EUCOMM)Wtsi HOM Male postnatal 2.43E-5
decreased total body fat amount Zfyve28tm1b(EUCOMM)Wtsi HOM Male postnatal 3.65E-5
decreased bone mineral density Zfyve28tm1b(EUCOMM)Wtsi HOM Female postnatal 6.18E-5
increased bone mineral density Zfyve28tm1b(EUCOMM)Wtsi HOM Male postnatal 6.18E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (1/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse nervous system reproductive system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (4)
  • Zfyve28tm1b(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    trigeminal V nerve, peripheral nervous system, HET, Female, WTSI
nervous system (3)
  • Zfyve28tm1b(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    trigeminal V nerve, peripheral nervous system, HET, Female, WTSI
trunk (2)
  • Zfyve28tm1b(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
reproductive system (1)
  • Zfyve28tm1b(EUCOMM)Wtsi
    testis, HET, Male, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    46 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • Eye Morphology: Images Slit Lamp
    6 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    18 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (74)
  • Zfyve28tm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    HOM, Male, WTSI

show all 74 images

Eye Morphology (6)
  • Zfyve28tm1b(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    mydriasis, abnormal pupil morphology, impaired pupillary reflex, HOM, Female, WTSI
  • Zfyve28tm1b(EUCOMM)Wtsi
    corneal ulcer, HOM, Female, WTSI

show all 6 images

Histology Slide (1)
  • Zfyve28tm1b(EUCOMM)Wtsi
    TS20 skin, HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Zfyve28tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Zfyve28tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Zfyve28tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene