banner
Genes Phenotypes Help, News, Blog

Gene: Mir127 MGI:2676812

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
microRNA 127
Synonyms:
Mirn127,  mmu-mir-127

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mir127 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mir127 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Placental Insufficiency
Abnormal placenta morphology, Small placenta, Miscarriage, Proportionate short stature, Abnormal ... ORPHA:439167
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Postnatal growth retardation, Large placenta, Polyhydramnios, Umbilical hernia ORPHA:254534
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Postnatal growth retardation, Small placenta, Severe postnatal growth retardation, Severe intraut... ORPHA:73272
Silver-Russell Syndrome Due To 11P15 Microduplication
Postnatal growth retardation, Decreased fetal movement, Severe intrauterine growth retardation, S... ORPHA:231144
Mitochondrial Complex I Deficiency, Nuclear Type 30
Intrauterine growth retardation, Neonatal death, Premature birth OMIM:301021
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Postnatal growth retardation, Large placenta, Polyhydramnios, Umbilical hernia, Intrauterine grow... ORPHA:254528
Silver-Russell Syndrome Due To A Point Mutation
Intrauterine growth retardation, Oligohydramnios, Small placenta, Postnatal growth retardation ORPHA:397590
Kagami-Ogata Syndrome
Postnatal growth retardation, Polyhydramnios, Large placenta, Premature birth ORPHA:254519
Congenital Syphilis
Intrauterine growth retardation, Hydrops fetalis, Large placenta, Premature birth ORPHA:499009
Greenberg Dysplasia
Stillbirth, Large placenta, Hydrops fetalis, Rhizomelia, Polyhydramnios, Disproportionate short-l... OMIM:215140
Mosaic Trisomy 16
Intrauterine growth retardation, Single umbilical artery, Large placenta, Premature birth ORPHA:1708
Trichohepatoenteric Syndrome 1
Large placenta, Polyhydramnios, Short stature, Abnormalities of placenta or umbilical cord, Intra... OMIM:222470
Restrictive Dermopathy 1
Stillbirth, Short umbilical cord, Polyhydramnios, Spontaneous chorioamniotic separation, Neonatal... OMIM:275210
Restrictive Dermopathy
Short umbilical cord, Large placenta, Polyhydramnios, Small placenta, Premature birth, Premature ... ORPHA:1662
Fetal Akinesia Deformation Sequence 1
Stillbirth, Short umbilical cord, Polyhydramnios, Small placenta, Increased nuchal translucency, ... OMIM:208150
Meckel Syndrome, Type 1
Occipital encephalocele, Large placenta, Single umbilical artery, Breech presentation, Anencephal... OMIM:249000
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Postnatal growth retardation, Large placenta, Polyhydramnios, Miscarriage, Short stature, Growth ... ORPHA:96334
Neu-Laxova Syndrome 1
Stillbirth, Short umbilical cord, Polyhydramnios, Small placenta, Hydranencephaly, Spina bifida, ... OMIM:256520
Beckwith-Wiedemann Syndrome
Subchorionic septal cyst, Large placenta, Polyhydramnios, Premature birth, Umbilical hernia ORPHA:116

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mir127

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mir127.

No publications found that use IMPC mice or data for Mir127.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mir127tm1(mirKO)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter